Spatiotemporal dynamics of EEG microstates in four- to eight-year-old children: Age- and sex-related effects
The ultrafast spatiotemporal dynamics of large-scale neural networks can be examined using resting-state electroencephalography (EEG) microstates, representing transient periods of synchronized neural activity that evolve dynamically over time. In adults, four canonical microstates have been shown t...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | Developmental Cognitive Neuroscience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929322000779 |
| _version_ | 1811208395446812672 |
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| author | Armen Bagdasarov Kenneth Roberts Lucie Bréchet Denis Brunet Christoph M. Michel Michael S. Gaffrey |
| author_facet | Armen Bagdasarov Kenneth Roberts Lucie Bréchet Denis Brunet Christoph M. Michel Michael S. Gaffrey |
| author_sort | Armen Bagdasarov |
| collection | DOAJ |
| description | The ultrafast spatiotemporal dynamics of large-scale neural networks can be examined using resting-state electroencephalography (EEG) microstates, representing transient periods of synchronized neural activity that evolve dynamically over time. In adults, four canonical microstates have been shown to explain most topographic variance in resting-state EEG. Their temporal structures are age-, sex- and state-dependent, and are susceptible to pathological brain states. However, no studies have assessed the spatial and temporal properties of EEG microstates exclusively during early childhood, a critical period of rapid brain development. Here we sought to investigate EEG microstates recorded with high-density EEG in a large sample of 103, 4–8-year-old children. Using data-driven k-means cluster analysis, we show that the four canonical microstates reported in adult populations already exist in early childhood. Using multiple linear regressions, we demonstrate that the temporal dynamics of two microstates are associated with age and sex. Source localization suggests that attention- and cognitive control-related networks govern the topographies of the age- and sex-dependent microstates. These novel findings provide unique insights into functional brain development in children captured with EEG microstates. |
| first_indexed | 2024-04-12T04:20:31Z |
| format | Article |
| id | doaj.art-d9d6f400c33942cfb7ccc76ffe606139 |
| institution | Directory Open Access Journal |
| issn | 1878-9293 |
| language | English |
| last_indexed | 2024-04-12T04:20:31Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj.art-d9d6f400c33942cfb7ccc76ffe6061392022-12-22T03:48:15ZengElsevierDevelopmental Cognitive Neuroscience1878-92932022-10-0157101134Spatiotemporal dynamics of EEG microstates in four- to eight-year-old children: Age- and sex-related effectsArmen Bagdasarov0Kenneth Roberts1Lucie Bréchet2Denis Brunet3Christoph M. Michel4Michael S. Gaffrey5Department of Psychology & Neuroscience, Duke University, Reuben-Cooke Building, 417 Chapel Drive, Durham, NC 27708, USA; Corresponding author.Duke Institute for Brain Sciences, Duke University, 308 Research Drive, Durham, NC, USADepartment of Basic Neurosciences, University of Geneva, Campus Biotech, 9 Chemin des Mines, 1202 Geneva, SwitzerlandDepartment of Basic Neurosciences, University of Geneva, Campus Biotech, 9 Chemin des Mines, 1202 Geneva, Switzerland; Center for Biomedical Imaging (CIBM) Lausanne, EPFL AVP CP CIBM Station 6, 1015 Lausanne SwitzerlandDepartment of Basic Neurosciences, University of Geneva, Campus Biotech, 9 Chemin des Mines, 1202 Geneva, Switzerland; Center for Biomedical Imaging (CIBM) Lausanne, EPFL AVP CP CIBM Station 6, 1015 Lausanne SwitzerlandDepartment of Psychology & Neuroscience, Duke University, Reuben-Cooke Building, 417 Chapel Drive, Durham, NC 27708, USAThe ultrafast spatiotemporal dynamics of large-scale neural networks can be examined using resting-state electroencephalography (EEG) microstates, representing transient periods of synchronized neural activity that evolve dynamically over time. In adults, four canonical microstates have been shown to explain most topographic variance in resting-state EEG. Their temporal structures are age-, sex- and state-dependent, and are susceptible to pathological brain states. However, no studies have assessed the spatial and temporal properties of EEG microstates exclusively during early childhood, a critical period of rapid brain development. Here we sought to investigate EEG microstates recorded with high-density EEG in a large sample of 103, 4–8-year-old children. Using data-driven k-means cluster analysis, we show that the four canonical microstates reported in adult populations already exist in early childhood. Using multiple linear regressions, we demonstrate that the temporal dynamics of two microstates are associated with age and sex. Source localization suggests that attention- and cognitive control-related networks govern the topographies of the age- and sex-dependent microstates. These novel findings provide unique insights into functional brain development in children captured with EEG microstates.http://www.sciencedirect.com/science/article/pii/S1878929322000779EEG microstatesResting-state networksBrain developmentChildrenAgeSex differences |
| spellingShingle | Armen Bagdasarov Kenneth Roberts Lucie Bréchet Denis Brunet Christoph M. Michel Michael S. Gaffrey Spatiotemporal dynamics of EEG microstates in four- to eight-year-old children: Age- and sex-related effects Developmental Cognitive Neuroscience EEG microstates Resting-state networks Brain development Children Age Sex differences |
| title | Spatiotemporal dynamics of EEG microstates in four- to eight-year-old children: Age- and sex-related effects |
| title_full | Spatiotemporal dynamics of EEG microstates in four- to eight-year-old children: Age- and sex-related effects |
| title_fullStr | Spatiotemporal dynamics of EEG microstates in four- to eight-year-old children: Age- and sex-related effects |
| title_full_unstemmed | Spatiotemporal dynamics of EEG microstates in four- to eight-year-old children: Age- and sex-related effects |
| title_short | Spatiotemporal dynamics of EEG microstates in four- to eight-year-old children: Age- and sex-related effects |
| title_sort | spatiotemporal dynamics of eeg microstates in four to eight year old children age and sex related effects |
| topic | EEG microstates Resting-state networks Brain development Children Age Sex differences |
| url | http://www.sciencedirect.com/science/article/pii/S1878929322000779 |
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