Tobramycin: efficacy of intensive therapy
One of the leading cause of the decrease of treatment efficacy in patient with community-acquired infections in the intensive care department is a spread of antibiotic resistance in main causative agents. Among Gram-negative microorganisms Pseudomonas aeruginosa is one of the leading causative agent...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Interdisciplinary Academy of Pain Medicine
2021-03-01
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| Series: | Perioperative Medicine |
| Subjects: | |
| Online Access: | https://perioperative.org.ua/index.php/prtmdc/article/view/47 |
| _version_ | 1819005416902754304 |
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| author | D V Dmytriiev O A Nazarchuk Yu M Babina O V Bankovskiy |
| author_facet | D V Dmytriiev O A Nazarchuk Yu M Babina O V Bankovskiy |
| author_sort | D V Dmytriiev |
| collection | DOAJ |
| description | One of the leading cause of the decrease of treatment efficacy in patient with community-acquired infections in the intensive care department is a spread of antibiotic resistance in main causative agents. Among Gram-negative microorganisms Pseudomonas aeruginosa is one of the leading causative agents, that is related to health service. A review of foreign and domestic literature concerning tobramycin – systemic form use in the current medical practice in the conditions of increasing resistance of microorganisms to the most broad-spectrum antibiotics is presented in the article. Pharmacokinetic and pharmacodynamic characteristics of tobramycin are described, results of clinical trials, that demonstrate an efficacy of its use in the combination with other antibiotics in the life-threatening infections caused by Gram-negative microorganisms are presented in the article. |
| first_indexed | 2024-12-20T23:52:27Z |
| format | Article |
| id | doaj.art-d9db26f1a3e44894867b173c7c80ed72 |
| institution | Directory Open Access Journal |
| issn | 2616-339X 2617-2925 |
| language | Russian |
| last_indexed | 2024-12-20T23:52:27Z |
| publishDate | 2021-03-01 |
| publisher | Interdisciplinary Academy of Pain Medicine |
| record_format | Article |
| series | Perioperative Medicine |
| spelling | doaj.art-d9db26f1a3e44894867b173c7c80ed722022-12-21T19:22:49ZrusInterdisciplinary Academy of Pain MedicinePerioperative Medicine2616-339X2617-29252021-03-013210.31636/prmd.v3i2.1Tobramycin: efficacy of intensive therapyD V Dmytriiev 0O A Nazarchuk1Yu M Babina2O V Bankovskiy 3National Pirogov Memorial Medical University, VinnytsiaNational Pirogov Memorial Medical University, VinnytsiaNational Pirogov Memorial Medical University, VinnytsiaNational Pirogov Memorial Medical University, VinnytsiaOne of the leading cause of the decrease of treatment efficacy in patient with community-acquired infections in the intensive care department is a spread of antibiotic resistance in main causative agents. Among Gram-negative microorganisms Pseudomonas aeruginosa is one of the leading causative agents, that is related to health service. A review of foreign and domestic literature concerning tobramycin – systemic form use in the current medical practice in the conditions of increasing resistance of microorganisms to the most broad-spectrum antibiotics is presented in the article. Pharmacokinetic and pharmacodynamic characteristics of tobramycin are described, results of clinical trials, that demonstrate an efficacy of its use in the combination with other antibiotics in the life-threatening infections caused by Gram-negative microorganisms are presented in the article.https://perioperative.org.ua/index.php/prtmdc/article/view/47aminoglycosidestobramycinPseudomonas aeruginosa |
| spellingShingle | D V Dmytriiev O A Nazarchuk Yu M Babina O V Bankovskiy Tobramycin: efficacy of intensive therapy Perioperative Medicine aminoglycosides tobramycin Pseudomonas aeruginosa |
| title | Tobramycin: efficacy of intensive therapy |
| title_full | Tobramycin: efficacy of intensive therapy |
| title_fullStr | Tobramycin: efficacy of intensive therapy |
| title_full_unstemmed | Tobramycin: efficacy of intensive therapy |
| title_short | Tobramycin: efficacy of intensive therapy |
| title_sort | tobramycin efficacy of intensive therapy |
| topic | aminoglycosides tobramycin Pseudomonas aeruginosa |
| url | https://perioperative.org.ua/index.php/prtmdc/article/view/47 |
| work_keys_str_mv | AT dvdmytriiev tobramycinefficacyofintensivetherapy AT oanazarchuk tobramycinefficacyofintensivetherapy AT yumbabina tobramycinefficacyofintensivetherapy AT ovbankovskiy tobramycinefficacyofintensivetherapy |