Neutrophils: New Critical Regulators of Glioma
In cancer, neutrophils are an important part of the tumour microenvironment (TME). Previous studies have shown that circulating and infiltrating neutrophils are associated with malignant progression and immunosuppression in gliomas. However, recent studies have shown that neutrophils have an antitum...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.927233/full |
| _version_ | 1828469768533835776 |
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| author | Guanyu Wang Jinpeng Wang Chaoshi Niu Chaoshi Niu Chaoshi Niu Chaoshi Niu Yan Zhao Pengfei Wu Pengfei Wu Pengfei Wu Pengfei Wu Pengfei Wu |
| author_facet | Guanyu Wang Jinpeng Wang Chaoshi Niu Chaoshi Niu Chaoshi Niu Chaoshi Niu Yan Zhao Pengfei Wu Pengfei Wu Pengfei Wu Pengfei Wu Pengfei Wu |
| author_sort | Guanyu Wang |
| collection | DOAJ |
| description | In cancer, neutrophils are an important part of the tumour microenvironment (TME). Previous studies have shown that circulating and infiltrating neutrophils are associated with malignant progression and immunosuppression in gliomas. However, recent studies have shown that neutrophils have an antitumour effect. In this review, we focus on the functional roles of neutrophils in the circulation and tumour sites in patients with glioma. The mechanisms of neutrophil recruitment, immunosuppression and the differentiation of neutrophils are discussed. Finally, the potential of neutrophils as clinical biomarkers and therapeutic targets is highlighted. This review can help us gain a deeper and systematic understanding of the role of neutrophils, and provide new insights for treatment in gliomas. |
| first_indexed | 2024-12-11T04:43:47Z |
| format | Article |
| id | doaj.art-d9df0bee3df74bc98766481dca3acd59 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T04:43:47Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-d9df0bee3df74bc98766481dca3acd592022-12-22T01:20:33ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-07-011310.3389/fimmu.2022.927233927233Neutrophils: New Critical Regulators of GliomaGuanyu Wang0Jinpeng Wang1Chaoshi Niu2Chaoshi Niu3Chaoshi Niu4Chaoshi Niu5Yan Zhao6Pengfei Wu7Pengfei Wu8Pengfei Wu9Pengfei Wu10Pengfei Wu11Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Urology, The Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, ChinaAnhui Provincial Stereotactic Neurosurgical Institute, Hefei, ChinaAnhui Province Key Laboratory of Brain Function and Brain Disease, Hefei, ChinaAnhui Provincial Clinical Research Center for Neurosurgical Disease, Hefei, ChinaDepartment of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, ChinaAnhui Provincial Stereotactic Neurosurgical Institute, Hefei, ChinaAnhui Province Key Laboratory of Brain Function and Brain Disease, Hefei, ChinaAnhui Provincial Clinical Research Center for Neurosurgical Disease, Hefei, ChinaAnhui Province Key Laboratory of Translational Cancer Research, Bengbu Medical College, Bengbu, ChinaIn cancer, neutrophils are an important part of the tumour microenvironment (TME). Previous studies have shown that circulating and infiltrating neutrophils are associated with malignant progression and immunosuppression in gliomas. However, recent studies have shown that neutrophils have an antitumour effect. In this review, we focus on the functional roles of neutrophils in the circulation and tumour sites in patients with glioma. The mechanisms of neutrophil recruitment, immunosuppression and the differentiation of neutrophils are discussed. Finally, the potential of neutrophils as clinical biomarkers and therapeutic targets is highlighted. This review can help us gain a deeper and systematic understanding of the role of neutrophils, and provide new insights for treatment in gliomas.https://www.frontiersin.org/articles/10.3389/fimmu.2022.927233/fullgliomaneutrophilstumour microenvironmentimmunosuppressiontreatment |
| spellingShingle | Guanyu Wang Jinpeng Wang Chaoshi Niu Chaoshi Niu Chaoshi Niu Chaoshi Niu Yan Zhao Pengfei Wu Pengfei Wu Pengfei Wu Pengfei Wu Pengfei Wu Neutrophils: New Critical Regulators of Glioma Frontiers in Immunology glioma neutrophils tumour microenvironment immunosuppression treatment |
| title | Neutrophils: New Critical Regulators of Glioma |
| title_full | Neutrophils: New Critical Regulators of Glioma |
| title_fullStr | Neutrophils: New Critical Regulators of Glioma |
| title_full_unstemmed | Neutrophils: New Critical Regulators of Glioma |
| title_short | Neutrophils: New Critical Regulators of Glioma |
| title_sort | neutrophils new critical regulators of glioma |
| topic | glioma neutrophils tumour microenvironment immunosuppression treatment |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.927233/full |
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