Nasal Cytology on 241 Children: From Birth to the First 3 Years of Life and Association with Common Airways Diseases
Background: Nasal cytology at birth and in the pediatric age is barely investigated regarding its association with the onset of common pediatric diseases. Methods: We enrolled 241 newborns within their first 24 h of life, studying their nasal cellular composition and repeating this at 1 and 3 years...
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| Format: | Article |
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MDPI AG
2023-04-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/13/4/687 |
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| author | Cecilia Rosso Federica Turati Alberto Maria Saibene Elvira Verduci Emanuela Fuccillo Maria Chiara Tavilla Mauro Magnani Giuseppe Banderali Monica Ferraroni Eugenio De Corso Giovanni Felisati Carlotta Pipolo |
| author_facet | Cecilia Rosso Federica Turati Alberto Maria Saibene Elvira Verduci Emanuela Fuccillo Maria Chiara Tavilla Mauro Magnani Giuseppe Banderali Monica Ferraroni Eugenio De Corso Giovanni Felisati Carlotta Pipolo |
| author_sort | Cecilia Rosso |
| collection | DOAJ |
| description | Background: Nasal cytology at birth and in the pediatric age is barely investigated regarding its association with the onset of common pediatric diseases. Methods: We enrolled 241 newborns within their first 24 h of life, studying their nasal cellular composition and repeating this at 1 and 3 years of life. We collected anamneses of perinatal factors and external factors (parental smoking, passive smoking, breastfeeding), and the prevalence of otitis, rhinosinusitis, bronchitis, asthma, and allergy at all timepoints. Results: 204 children completed the study. At birth, there was a prevalence of ciliated cells and rare neutrophils. At 1 and 3 years, ciliated cells started reducing in favor of muciparous cells and neutrophils. We found that caesarian delivery and nasogastric tube usage for choanal patency are significantly related to a certain cellular nasal composition. Additionally, development of upper respiratory tract infections, AOM (acute otitis media) and allergy correlates with specific cytological compositions which may predict those pathologies. Conclusions: Our study is the first to show the normal nasal mucosa cellular composition and development in the first 3 years of life in a large cohort. Nasal cytology may be a tool for early risk assessment in the occurrence of upper airway disease. |
| first_indexed | 2024-03-11T04:51:26Z |
| format | Article |
| id | doaj.art-d9df47ed46f44be28553e37aa084ac39 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-11T04:51:26Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-d9df47ed46f44be28553e37aa084ac392023-11-17T20:00:44ZengMDPI AGJournal of Personalized Medicine2075-44262023-04-0113468710.3390/jpm13040687Nasal Cytology on 241 Children: From Birth to the First 3 Years of Life and Association with Common Airways DiseasesCecilia Rosso0Federica Turati1Alberto Maria Saibene2Elvira Verduci3Emanuela Fuccillo4Maria Chiara Tavilla5Mauro Magnani6Giuseppe Banderali7Monica Ferraroni8Eugenio De Corso9Giovanni Felisati10Carlotta Pipolo11Department of Otorhinolaryngology, Santi Paolo e Carlo Hospital, Università degli Studi di Milano, 20148 Milan, ItalyBranch of Medical Statistics, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, ItalyDepartment of Otorhinolaryngology, Santi Paolo e Carlo Hospital, Università degli Studi di Milano, 20148 Milan, ItalyPediatric Department, “Vittore Buzzi” Children’s Hospital, 20154 Milan, ItalyDepartment of Otorhinolaryngology, Santi Paolo e Carlo Hospital, Università degli Studi di Milano, 20148 Milan, ItalyDepartment of Otorhinolaryngology, Santi Paolo e Carlo Hospital, Università degli Studi di Milano, 20148 Milan, ItalyDepartment of Hand Surgery and Microsurgery, Gaetano Pini—CTO Orthopaedic Institute, University of Milan, 20122 Milan, ItalyPediatric Department, Santi Paolo e Carlo Hospital, Università degli Studi di Milano, 20148 Milan, ItalyBranch of Medical Statistics, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, ItalyDepartment of Otorhinolaryngology, La Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Universita Cattolica del Sacro Cuore, 00168 Rome, ItalyDepartment of Otorhinolaryngology, Santi Paolo e Carlo Hospital, Università degli Studi di Milano, 20148 Milan, ItalyDepartment of Otorhinolaryngology, Santi Paolo e Carlo Hospital, Università degli Studi di Milano, 20148 Milan, ItalyBackground: Nasal cytology at birth and in the pediatric age is barely investigated regarding its association with the onset of common pediatric diseases. Methods: We enrolled 241 newborns within their first 24 h of life, studying their nasal cellular composition and repeating this at 1 and 3 years of life. We collected anamneses of perinatal factors and external factors (parental smoking, passive smoking, breastfeeding), and the prevalence of otitis, rhinosinusitis, bronchitis, asthma, and allergy at all timepoints. Results: 204 children completed the study. At birth, there was a prevalence of ciliated cells and rare neutrophils. At 1 and 3 years, ciliated cells started reducing in favor of muciparous cells and neutrophils. We found that caesarian delivery and nasogastric tube usage for choanal patency are significantly related to a certain cellular nasal composition. Additionally, development of upper respiratory tract infections, AOM (acute otitis media) and allergy correlates with specific cytological compositions which may predict those pathologies. Conclusions: Our study is the first to show the normal nasal mucosa cellular composition and development in the first 3 years of life in a large cohort. Nasal cytology may be a tool for early risk assessment in the occurrence of upper airway disease.https://www.mdpi.com/2075-4426/13/4/687nasal cytologychildrennewbornsotitisasthmaURTI |
| spellingShingle | Cecilia Rosso Federica Turati Alberto Maria Saibene Elvira Verduci Emanuela Fuccillo Maria Chiara Tavilla Mauro Magnani Giuseppe Banderali Monica Ferraroni Eugenio De Corso Giovanni Felisati Carlotta Pipolo Nasal Cytology on 241 Children: From Birth to the First 3 Years of Life and Association with Common Airways Diseases Journal of Personalized Medicine nasal cytology children newborns otitis asthma URTI |
| title | Nasal Cytology on 241 Children: From Birth to the First 3 Years of Life and Association with Common Airways Diseases |
| title_full | Nasal Cytology on 241 Children: From Birth to the First 3 Years of Life and Association with Common Airways Diseases |
| title_fullStr | Nasal Cytology on 241 Children: From Birth to the First 3 Years of Life and Association with Common Airways Diseases |
| title_full_unstemmed | Nasal Cytology on 241 Children: From Birth to the First 3 Years of Life and Association with Common Airways Diseases |
| title_short | Nasal Cytology on 241 Children: From Birth to the First 3 Years of Life and Association with Common Airways Diseases |
| title_sort | nasal cytology on 241 children from birth to the first 3 years of life and association with common airways diseases |
| topic | nasal cytology children newborns otitis asthma URTI |
| url | https://www.mdpi.com/2075-4426/13/4/687 |
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