Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population
Xuling Chang et al. study whether low frequency variants are associated with leukocyte telomere length and whether these variants predispose to incident cancers and mortalities among East Asians. They find that three East Asian specific variants at POT1, TERF1 and STN1 loci are associated with leuko...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-05-01
|
| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02056-7 |
| _version_ | 1818843352336957440 |
|---|---|
| author | Xuling Chang Resham L. Gurung Ling Wang Aizhen Jin Zheng Li Renwei Wang Kenneth B. Beckman Jennifer Adams-Haduch Wee Yang Meah Kar Seng Sim Weng Khong Lim Sonia Davila Patrick Tan Jing Xian Teo Khung Keong Yeo Yiamunaa M. Sylvia Liu Su Chi Lim Jianjun Liu Rob M. van Dam Yechiel Friedlander Woon-Puay Koh Jian-Min Yuan Chiea Chuen Khor Chew-Kiat Heng Rajkumar Dorajoo |
| author_facet | Xuling Chang Resham L. Gurung Ling Wang Aizhen Jin Zheng Li Renwei Wang Kenneth B. Beckman Jennifer Adams-Haduch Wee Yang Meah Kar Seng Sim Weng Khong Lim Sonia Davila Patrick Tan Jing Xian Teo Khung Keong Yeo Yiamunaa M. Sylvia Liu Su Chi Lim Jianjun Liu Rob M. van Dam Yechiel Friedlander Woon-Puay Koh Jian-Min Yuan Chiea Chuen Khor Chew-Kiat Heng Rajkumar Dorajoo |
| author_sort | Xuling Chang |
| collection | DOAJ |
| description | Xuling Chang et al. study whether low frequency variants are associated with leukocyte telomere length and whether these variants predispose to incident cancers and mortalities among East Asians. They find that three East Asian specific variants at POT1, TERF1 and STN1 loci are associated with leukocyte telomere length and report a mechanistic pathway linking TERF1, leukocyte telomere length and incident colon cancer. |
| first_indexed | 2024-12-19T04:56:30Z |
| format | Article |
| id | doaj.art-d9e076b9b5cf4b79a5a972b56a383c9a |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-19T04:56:30Z |
| publishDate | 2021-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-d9e076b9b5cf4b79a5a972b56a383c9a2022-12-21T20:35:13ZengNature PortfolioCommunications Biology2399-36422021-05-01411910.1038/s42003-021-02056-7Low frequency variants associated with leukocyte telomere length in the Singapore Chinese populationXuling Chang0Resham L. Gurung1Ling Wang2Aizhen Jin3Zheng Li4Renwei Wang5Kenneth B. Beckman6Jennifer Adams-Haduch7Wee Yang Meah8Kar Seng Sim9Weng Khong Lim10Sonia Davila11Patrick Tan12Jing Xian Teo13Khung Keong Yeo14Yiamunaa M.15Sylvia Liu16Su Chi Lim17Jianjun Liu18Rob M. van Dam19Yechiel Friedlander20Woon-Puay Koh21Jian-Min Yuan22Chiea Chuen Khor23Chew-Kiat Heng24Rajkumar Dorajoo25Department of Paediatrics, Yong Loo Lin School of Medicine, National University of SingaporeClinical Research Unit, Khoo Teck Puat HospitalGenome Institute of Singapore, Agency for Science, Technology, and ResearchHealth Services and Systems Research, Duke-NUS Medical School SingaporeGenome Institute of Singapore, Agency for Science, Technology, and ResearchDivision of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of PittsburghUniversity of Minnesota Genomics Center, University of MinnesotaDivision of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of PittsburghGenome Institute of Singapore, Agency for Science, Technology, and ResearchGenome Institute of Singapore, Agency for Science, Technology, and ResearchSingHealth Duke-NUS Institute of Precision MedicineSingHealth Duke-NUS Institute of Precision MedicineGenome Institute of Singapore, Agency for Science, Technology, and ResearchSingHealth Duke-NUS Institute of Precision MedicineSingHealth Duke-NUS Institute of Precision MedicineClinical Research Unit, Khoo Teck Puat HospitalClinical Research Unit, Khoo Teck Puat HospitalClinical Research Unit, Khoo Teck Puat HospitalGenome Institute of Singapore, Agency for Science, Technology, and ResearchSaw Swee Hock School of Public Health, National University of SingaporeSchool of Public Health and Community Medicine, Hebrew University of JerusalemHealth Services and Systems Research, Duke-NUS Medical School SingaporeDivision of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of PittsburghGenome Institute of Singapore, Agency for Science, Technology, and ResearchDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of SingaporeGenome Institute of Singapore, Agency for Science, Technology, and ResearchXuling Chang et al. study whether low frequency variants are associated with leukocyte telomere length and whether these variants predispose to incident cancers and mortalities among East Asians. They find that three East Asian specific variants at POT1, TERF1 and STN1 loci are associated with leukocyte telomere length and report a mechanistic pathway linking TERF1, leukocyte telomere length and incident colon cancer.https://doi.org/10.1038/s42003-021-02056-7 |
| spellingShingle | Xuling Chang Resham L. Gurung Ling Wang Aizhen Jin Zheng Li Renwei Wang Kenneth B. Beckman Jennifer Adams-Haduch Wee Yang Meah Kar Seng Sim Weng Khong Lim Sonia Davila Patrick Tan Jing Xian Teo Khung Keong Yeo Yiamunaa M. Sylvia Liu Su Chi Lim Jianjun Liu Rob M. van Dam Yechiel Friedlander Woon-Puay Koh Jian-Min Yuan Chiea Chuen Khor Chew-Kiat Heng Rajkumar Dorajoo Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population Communications Biology |
| title | Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population |
| title_full | Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population |
| title_fullStr | Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population |
| title_full_unstemmed | Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population |
| title_short | Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population |
| title_sort | low frequency variants associated with leukocyte telomere length in the singapore chinese population |
| url | https://doi.org/10.1038/s42003-021-02056-7 |
| work_keys_str_mv | AT xulingchang lowfrequencyvariantsassociatedwithleukocytetelomerelengthinthesingaporechinesepopulation AT reshamlgurung lowfrequencyvariantsassociatedwithleukocytetelomerelengthinthesingaporechinesepopulation AT lingwang lowfrequencyvariantsassociatedwithleukocytetelomerelengthinthesingaporechinesepopulation AT aizhenjin lowfrequencyvariantsassociatedwithleukocytetelomerelengthinthesingaporechinesepopulation AT zhengli lowfrequencyvariantsassociatedwithleukocytetelomerelengthinthesingaporechinesepopulation AT renweiwang lowfrequencyvariantsassociatedwithleukocytetelomerelengthinthesingaporechinesepopulation AT kennethbbeckman lowfrequencyvariantsassociatedwithleukocytetelomerelengthinthesingaporechinesepopulation AT jenniferadamshaduch lowfrequencyvariantsassociatedwithleukocytetelomerelengthinthesingaporechinesepopulation AT weeyangmeah lowfrequencyvariantsassociatedwithleukocytetelomerelengthinthesingaporechinesepopulation AT karsengsim lowfrequencyvariantsassociatedwithleukocytetelomerelengthinthesingaporechinesepopulation AT wengkhonglim lowfrequencyvariantsassociatedwithleukocytetelomerelengthinthesingaporechinesepopulation AT soniadavila lowfrequencyvariantsassociatedwithleukocytetelomerelengthinthesingaporechinesepopulation AT patricktan lowfrequencyvariantsassociatedwithleukocytetelomerelengthinthesingaporechinesepopulation AT jingxianteo lowfrequencyvariantsassociatedwithleukocytetelomerelengthinthesingaporechinesepopulation AT khungkeongyeo lowfrequencyvariantsassociatedwithleukocytetelomerelengthinthesingaporechinesepopulation AT yiamunaam lowfrequencyvariantsassociatedwithleukocytetelomerelengthinthesingaporechinesepopulation AT sylvialiu lowfrequencyvariantsassociatedwithleukocytetelomerelengthinthesingaporechinesepopulation AT suchilim lowfrequencyvariantsassociatedwithleukocytetelomerelengthinthesingaporechinesepopulation AT jianjunliu lowfrequencyvariantsassociatedwithleukocytetelomerelengthinthesingaporechinesepopulation AT robmvandam lowfrequencyvariantsassociatedwithleukocytetelomerelengthinthesingaporechinesepopulation AT yechielfriedlander lowfrequencyvariantsassociatedwithleukocytetelomerelengthinthesingaporechinesepopulation AT woonpuaykoh lowfrequencyvariantsassociatedwithleukocytetelomerelengthinthesingaporechinesepopulation AT jianminyuan lowfrequencyvariantsassociatedwithleukocytetelomerelengthinthesingaporechinesepopulation AT chieachuenkhor lowfrequencyvariantsassociatedwithleukocytetelomerelengthinthesingaporechinesepopulation AT chewkiatheng lowfrequencyvariantsassociatedwithleukocytetelomerelengthinthesingaporechinesepopulation AT rajkumardorajoo lowfrequencyvariantsassociatedwithleukocytetelomerelengthinthesingaporechinesepopulation |