The Roles of Mitophagy and Autophagy in Ineffective Erythropoiesis in β-Thalassemia

The Roles of Mitophagy and Autophagy in Ineffective Erythropoiesis in β-Thalassemia

β-Thalassemia is one of the most common genetically inherited disorders worldwide, and it is characterized by defective β-globin chain synthesis leading to reduced or absent β-globin chains. The excess α-globin chains are the key factor leading to the death of differentiating erythroblasts in a proc...

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Bibliographic Details
Main Authors: Pornthip Chaichompoo, Saovaros Svasti, Duncan R. Smith
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
autophagy
apoptosis
ER stress
β-thalassemia
ineffective erythropoiesis
Online Access:https://www.mdpi.com/1422-0067/23/18/10811

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