Fabrication and Characterization of Strontium-Substituted Hydroxyapatite-CaO-CaCO3 Nanofibers with a Mesoporous Structure as Drug Delivery Carriers
Hydroxyapatite (HAp) is the main inorganic component and an essential part of hard bone and teeth. Due to its excellent biocompatibility, bioactivity, and osteoconductivity, synthetic HAp has been widely used as a bone substitute, cell carrier, and therapeutic gene or drug carrier. Recently, numerou...
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| Format: | Article |
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MDPI AG
2018-10-01
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| Series: | Pharmaceutics |
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| Online Access: | http://www.mdpi.com/1999-4923/10/4/179 |
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| author | Shiao-Wen Tsai Wen-Xin Yu Pai-An Hwang Sheng-Siang Huang Hsiu-Mei Lin Yu-Wei Hsu Fu-Yin Hsu |
| author_facet | Shiao-Wen Tsai Wen-Xin Yu Pai-An Hwang Sheng-Siang Huang Hsiu-Mei Lin Yu-Wei Hsu Fu-Yin Hsu |
| author_sort | Shiao-Wen Tsai |
| collection | DOAJ |
| description | Hydroxyapatite (HAp) is the main inorganic component and an essential part of hard bone and teeth. Due to its excellent biocompatibility, bioactivity, and osteoconductivity, synthetic HAp has been widely used as a bone substitute, cell carrier, and therapeutic gene or drug carrier. Recently, numerous studies have demonstrated that strontium-substituted hydroxyapatite (SrHAp) not only enhances osteogenesis but also inhibits adipogenesis in mesenchymal stem cells. Mesoporous SrHAp has been successfully synthesized via a traditional template-based process and has been found to possess better drug loading and release efficiencies than SrHAp. In this study, strontium-substituted hydroxyapatite-CaO-CaCO3 nanofibers with a mesoporous structure (mSrHANFs) were fabricated using a sol–gel method followed by electrospinning. X-ray diffraction analysis revealed that the contents of CaO and CaCO3 in the mSrHANFs decreased as the doping amount of Sr increased. Scanning electron microscopy (SEM) images showed that the average diameter of the mSrHANFs was approximately 200~300 nm. The N2 adsorption–desorption isotherms demonstrated that the mSrHANFs possessed a mesoporous structure and that the average pore size was approximately 20~25 nm. Moreover, the mSrHANFs had excellent drug- loading efficiency and could retard the burst release of tetracycline (TC) to maintain antibacterial activity for over 3 weeks. Hence, mSrHANFs have the potential to be used as drug carriers in bone tissue engineering. |
| first_indexed | 2024-04-13T06:40:38Z |
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| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-13T06:40:38Z |
| publishDate | 2018-10-01 |
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| series | Pharmaceutics |
| spelling | doaj.art-d9e0f8d8494f4644a14fb98ba7fa2d172022-12-22T02:57:45ZengMDPI AGPharmaceutics1999-49232018-10-0110417910.3390/pharmaceutics10040179pharmaceutics10040179Fabrication and Characterization of Strontium-Substituted Hydroxyapatite-CaO-CaCO3 Nanofibers with a Mesoporous Structure as Drug Delivery CarriersShiao-Wen Tsai0Wen-Xin Yu1Pai-An Hwang2Sheng-Siang Huang3Hsiu-Mei Lin4Yu-Wei Hsu5Fu-Yin Hsu6Graduate Institute of Biomedical Engineering, Chang Gung University, Taoyuan City 33302, TaiwanDepartment of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung City 20224, TaiwanDepartment of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung City 20224, TaiwanDepartment of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung City 20224, TaiwanDepartment of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung City 20224, TaiwanDepartment of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung City 20224, TaiwanDepartment of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung City 20224, TaiwanHydroxyapatite (HAp) is the main inorganic component and an essential part of hard bone and teeth. Due to its excellent biocompatibility, bioactivity, and osteoconductivity, synthetic HAp has been widely used as a bone substitute, cell carrier, and therapeutic gene or drug carrier. Recently, numerous studies have demonstrated that strontium-substituted hydroxyapatite (SrHAp) not only enhances osteogenesis but also inhibits adipogenesis in mesenchymal stem cells. Mesoporous SrHAp has been successfully synthesized via a traditional template-based process and has been found to possess better drug loading and release efficiencies than SrHAp. In this study, strontium-substituted hydroxyapatite-CaO-CaCO3 nanofibers with a mesoporous structure (mSrHANFs) were fabricated using a sol–gel method followed by electrospinning. X-ray diffraction analysis revealed that the contents of CaO and CaCO3 in the mSrHANFs decreased as the doping amount of Sr increased. Scanning electron microscopy (SEM) images showed that the average diameter of the mSrHANFs was approximately 200~300 nm. The N2 adsorption–desorption isotherms demonstrated that the mSrHANFs possessed a mesoporous structure and that the average pore size was approximately 20~25 nm. Moreover, the mSrHANFs had excellent drug- loading efficiency and could retard the burst release of tetracycline (TC) to maintain antibacterial activity for over 3 weeks. Hence, mSrHANFs have the potential to be used as drug carriers in bone tissue engineering.http://www.mdpi.com/1999-4923/10/4/179strontiumhydroxyapatitemesoporousdrug delivery |
| spellingShingle | Shiao-Wen Tsai Wen-Xin Yu Pai-An Hwang Sheng-Siang Huang Hsiu-Mei Lin Yu-Wei Hsu Fu-Yin Hsu Fabrication and Characterization of Strontium-Substituted Hydroxyapatite-CaO-CaCO3 Nanofibers with a Mesoporous Structure as Drug Delivery Carriers Pharmaceutics strontium hydroxyapatite mesoporous drug delivery |
| title | Fabrication and Characterization of Strontium-Substituted Hydroxyapatite-CaO-CaCO3 Nanofibers with a Mesoporous Structure as Drug Delivery Carriers |
| title_full | Fabrication and Characterization of Strontium-Substituted Hydroxyapatite-CaO-CaCO3 Nanofibers with a Mesoporous Structure as Drug Delivery Carriers |
| title_fullStr | Fabrication and Characterization of Strontium-Substituted Hydroxyapatite-CaO-CaCO3 Nanofibers with a Mesoporous Structure as Drug Delivery Carriers |
| title_full_unstemmed | Fabrication and Characterization of Strontium-Substituted Hydroxyapatite-CaO-CaCO3 Nanofibers with a Mesoporous Structure as Drug Delivery Carriers |
| title_short | Fabrication and Characterization of Strontium-Substituted Hydroxyapatite-CaO-CaCO3 Nanofibers with a Mesoporous Structure as Drug Delivery Carriers |
| title_sort | fabrication and characterization of strontium substituted hydroxyapatite cao caco3 nanofibers with a mesoporous structure as drug delivery carriers |
| topic | strontium hydroxyapatite mesoporous drug delivery |
| url | http://www.mdpi.com/1999-4923/10/4/179 |
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