Hepatitis C-related cryoglobulinemic neuropathy: potential role of oxcarbazepine for pain control
Abstract Background Peripheral neuropathy is one most common, limiting and invalidating neurological symptom in subjects with hepatitis C virus and mixed cryoglobulinemia. Notably, the medical therapy proposed to eradicate HCV, can frequently exacerbate the painful neuropathy. Therefore, neuropathy...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-01-01
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| Series: | BMC Gastroenterology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12876-018-0751-9 |
| _version_ | 1818280131454566400 |
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| author | Rita Moretti Paola Caruso Matteo Dal Ben Silvia Gazzin Claudio Tiribelli |
| author_facet | Rita Moretti Paola Caruso Matteo Dal Ben Silvia Gazzin Claudio Tiribelli |
| author_sort | Rita Moretti |
| collection | DOAJ |
| description | Abstract Background Peripheral neuropathy is one most common, limiting and invalidating neurological symptom in subjects with hepatitis C virus and mixed cryoglobulinemia. Notably, the medical therapy proposed to eradicate HCV, can frequently exacerbate the painful neuropathy. Therefore, neuropathy therapies are insufficient and inadequate, and comprise immunosuppressive drugs, such as steroid or cyclosporine, intravenous immunoglobulin or plasma exchange. These have shown variable success in case reports, with a presumably temporary effect, but with major side effects. Methods We assessed the effects of oxcarbazepine treatment in 67 cases of cryoglobulinemia related neuropathy, who did not respond to either steroid or Gabapentin, or Pregabalin. Oxcarbazepine was chosen based on the promising preliminary results. Results Patients treated with Oxcarbazepine showed a rapid, discrete and persistent relief of polyneuropathic signs, without consistent side effects, and with a limited interaction with concomitant drugs. Conclusions These data favor the use of oxcarbazepine as a useful tool in the management of neuropathic pain associated with Hepatitis–C cryoglobulin neuropathy. |
| first_indexed | 2024-12-12T23:44:21Z |
| format | Article |
| id | doaj.art-d9e1055044dd45cfb85038836b7cb89e |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-12-12T23:44:21Z |
| publishDate | 2018-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-d9e1055044dd45cfb85038836b7cb89e2022-12-22T00:06:58ZengBMCBMC Gastroenterology1471-230X2018-01-011811610.1186/s12876-018-0751-9Hepatitis C-related cryoglobulinemic neuropathy: potential role of oxcarbazepine for pain controlRita Moretti0Paola Caruso1Matteo Dal Ben2Silvia Gazzin3Claudio Tiribelli4Neurology Clinic, Department of Medical, Surgical, and Health Sciences, University of TriesteNeurology Clinic, Department of Medical, Surgical, and Health Sciences, University of TriesteNeurology Clinic, Department of Medical, Surgical, and Health Sciences, University of TriesteItalian Liver Foundation, Centro Studi FegatoItalian Liver Foundation, Centro Studi FegatoAbstract Background Peripheral neuropathy is one most common, limiting and invalidating neurological symptom in subjects with hepatitis C virus and mixed cryoglobulinemia. Notably, the medical therapy proposed to eradicate HCV, can frequently exacerbate the painful neuropathy. Therefore, neuropathy therapies are insufficient and inadequate, and comprise immunosuppressive drugs, such as steroid or cyclosporine, intravenous immunoglobulin or plasma exchange. These have shown variable success in case reports, with a presumably temporary effect, but with major side effects. Methods We assessed the effects of oxcarbazepine treatment in 67 cases of cryoglobulinemia related neuropathy, who did not respond to either steroid or Gabapentin, or Pregabalin. Oxcarbazepine was chosen based on the promising preliminary results. Results Patients treated with Oxcarbazepine showed a rapid, discrete and persistent relief of polyneuropathic signs, without consistent side effects, and with a limited interaction with concomitant drugs. Conclusions These data favor the use of oxcarbazepine as a useful tool in the management of neuropathic pain associated with Hepatitis–C cryoglobulin neuropathy.http://link.springer.com/article/10.1186/s12876-018-0751-9HCVOxcarbazepineNeuropathyPain |
| spellingShingle | Rita Moretti Paola Caruso Matteo Dal Ben Silvia Gazzin Claudio Tiribelli Hepatitis C-related cryoglobulinemic neuropathy: potential role of oxcarbazepine for pain control BMC Gastroenterology HCV Oxcarbazepine Neuropathy Pain |
| title | Hepatitis C-related cryoglobulinemic neuropathy: potential role of oxcarbazepine for pain control |
| title_full | Hepatitis C-related cryoglobulinemic neuropathy: potential role of oxcarbazepine for pain control |
| title_fullStr | Hepatitis C-related cryoglobulinemic neuropathy: potential role of oxcarbazepine for pain control |
| title_full_unstemmed | Hepatitis C-related cryoglobulinemic neuropathy: potential role of oxcarbazepine for pain control |
| title_short | Hepatitis C-related cryoglobulinemic neuropathy: potential role of oxcarbazepine for pain control |
| title_sort | hepatitis c related cryoglobulinemic neuropathy potential role of oxcarbazepine for pain control |
| topic | HCV Oxcarbazepine Neuropathy Pain |
| url | http://link.springer.com/article/10.1186/s12876-018-0751-9 |
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