Matrix Stiffening Enhances DNCB-Induced IL-6 Secretion in Keratinocytes Through Activation of ERK and PI3K/Akt Pathway

Matrix Stiffening Enhances DNCB-Induced IL-6 Secretion in Keratinocytes Through Activation of ERK and PI3K/Akt Pathway

Matrix stiffness, a critical physical property of the cellular environment, is implicated in epidermal homeostasis. In particular, matrix stiffening during the pathological progression of skin diseases appears to contribute to cellular responses of keratinocytes. However, it has not yet elucidated t...

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Bibliographic Details
Main Authors: Hyewon Chung, Seunghee Oh, Hyun-Woo Shin, Yunam Lee, Hyungsuk Lee, Seung Hyeok Seok
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Immunology
Subjects:
skin
keratinocyte
inflammatory response
IL-6
matrix stiffening
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.759992/full

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