Characteristics of lung cancer among patients with idiopathic pulmonary fibrosis and interstitial lung disease – analysis of institutional and population data
Abstract Background Lung Cancer is occasionally observed in patients with Idiopathic Pulmonary Fibrosis (IPF). We sought to describe the epidemiologic and clinical characteristics of lung cancer for patients with IPF and other interstitial lung disease (ILD) using institutional and statewide data re...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-10-01
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| Series: | Respiratory Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12931-018-0899-4 |
| _version_ | 1819206393998082048 |
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| author | Joo Heung Yoon Mehdi Nouraie Xiaoping Chen Richard H Zou Jacobo Sellares Kristen L Veraldi Jared Chiarchiaro Kathleen Lindell David O Wilson Naftali Kaminski Timothy Burns Humberto Trejo Bittar Samuel Yousem Kevin Gibson Daniel J Kass |
| author_facet | Joo Heung Yoon Mehdi Nouraie Xiaoping Chen Richard H Zou Jacobo Sellares Kristen L Veraldi Jared Chiarchiaro Kathleen Lindell David O Wilson Naftali Kaminski Timothy Burns Humberto Trejo Bittar Samuel Yousem Kevin Gibson Daniel J Kass |
| author_sort | Joo Heung Yoon |
| collection | DOAJ |
| description | Abstract Background Lung Cancer is occasionally observed in patients with Idiopathic Pulmonary Fibrosis (IPF). We sought to describe the epidemiologic and clinical characteristics of lung cancer for patients with IPF and other interstitial lung disease (ILD) using institutional and statewide data registries. Methods We conducted a retrospective analysis of IPF and non-IPF ILD patients from the ILD center registry, to compare with lung cancer registries at the University of Pittsburgh as well as with population data of lung cancer obtained from Pennsylvania Department of Health between 2000 and 2015. Results Among 1108 IPF patients, 31 patients were identified with IPF and lung cancer. The age-adjusted standard incidence ratio of lung cancer was 3.34 (with IPF) and 2.3 (with non-IPF ILD) (between-group Hazard ratio = 1.4, p = 0.3). Lung cancer worsened the mortality of IPF (p < 0.001). Lung cancer with IPF had higher mortality compared to lung cancer in non-IPF ILD (Hazard ratio = 6.2, p = 0.001). Lung cancer among IPF was characterized by a predilection for lower lobes (63% vs. 26% in non-IPF lung cancer, p < 0.001) and by squamous cell histology (41% vs. 29%, p = 0.07). Increased incidence of lung cancer was observed among single lung transplant (SLT) recipients for IPF (13 out of 97, 13.4%), with increased mortality compared to SLT for IPF without lung cancer (p = 0.028) during observational period. Conclusions Lung cancer is approximately 3.34 times more frequently diagnosed in IPF patients compared to general population, and associated with worse prognosis compared with IPF without lung cancer, with squamous cell carcinoma and lower lobe predilection. The causality between non-smoking IPF patients and lung cancer is to be determined. |
| first_indexed | 2024-12-23T05:06:54Z |
| format | Article |
| id | doaj.art-d9e31fe0e7ab4311a2b9beed83487a19 |
| institution | Directory Open Access Journal |
| issn | 1465-993X |
| language | English |
| last_indexed | 2024-12-23T05:06:54Z |
| publishDate | 2018-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-d9e31fe0e7ab4311a2b9beed83487a192022-12-21T17:59:03ZengBMCRespiratory Research1465-993X2018-10-0119111010.1186/s12931-018-0899-4Characteristics of lung cancer among patients with idiopathic pulmonary fibrosis and interstitial lung disease – analysis of institutional and population dataJoo Heung Yoon0Mehdi Nouraie1Xiaoping Chen2Richard H Zou3Jacobo Sellares4Kristen L Veraldi5Jared Chiarchiaro6Kathleen Lindell7David O Wilson8Naftali Kaminski9Timothy Burns10Humberto Trejo Bittar11Samuel Yousem12Kevin Gibson13Daniel J Kass14Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease and Division of Pulmonary, Allergy, and Critical Care Medicine, University of PittsburghDorothy P. and Richard P. Simmons Center for Interstitial Lung Disease and Division of Pulmonary, Allergy, and Critical Care Medicine, University of PittsburghDorothy P. and Richard P. Simmons Center for Interstitial Lung Disease and Division of Pulmonary, Allergy, and Critical Care Medicine, University of PittsburghDorothy P. and Richard P. Simmons Center for Interstitial Lung Disease and Division of Pulmonary, Allergy, and Critical Care Medicine, University of PittsburghDorothy P. and Richard P. Simmons Center for Interstitial Lung Disease and Division of Pulmonary, Allergy, and Critical Care Medicine, University of PittsburghDorothy P. and Richard P. Simmons Center for Interstitial Lung Disease and Division of Pulmonary, Allergy, and Critical Care Medicine, University of PittsburghDorothy P. and Richard P. Simmons Center for Interstitial Lung Disease and Division of Pulmonary, Allergy, and Critical Care Medicine, University of PittsburghDorothy P. and Richard P. Simmons Center for Interstitial Lung Disease and Division of Pulmonary, Allergy, and Critical Care Medicine, University of PittsburghDorothy P. and Richard P. Simmons Center for Interstitial Lung Disease and Division of Pulmonary, Allergy, and Critical Care Medicine, University of PittsburghSection of Pulmonary, Critical Care and Sleep Medicine, Yale UniversityDivision of Hematology and Oncology, University of PittsburghDepartment of Pathology, University of PittsburghDepartment of Pathology, University of PittsburghDorothy P. and Richard P. Simmons Center for Interstitial Lung Disease and Division of Pulmonary, Allergy, and Critical Care Medicine, University of PittsburghDorothy P. and Richard P. Simmons Center for Interstitial Lung Disease and Division of Pulmonary, Allergy, and Critical Care Medicine, University of PittsburghAbstract Background Lung Cancer is occasionally observed in patients with Idiopathic Pulmonary Fibrosis (IPF). We sought to describe the epidemiologic and clinical characteristics of lung cancer for patients with IPF and other interstitial lung disease (ILD) using institutional and statewide data registries. Methods We conducted a retrospective analysis of IPF and non-IPF ILD patients from the ILD center registry, to compare with lung cancer registries at the University of Pittsburgh as well as with population data of lung cancer obtained from Pennsylvania Department of Health between 2000 and 2015. Results Among 1108 IPF patients, 31 patients were identified with IPF and lung cancer. The age-adjusted standard incidence ratio of lung cancer was 3.34 (with IPF) and 2.3 (with non-IPF ILD) (between-group Hazard ratio = 1.4, p = 0.3). Lung cancer worsened the mortality of IPF (p < 0.001). Lung cancer with IPF had higher mortality compared to lung cancer in non-IPF ILD (Hazard ratio = 6.2, p = 0.001). Lung cancer among IPF was characterized by a predilection for lower lobes (63% vs. 26% in non-IPF lung cancer, p < 0.001) and by squamous cell histology (41% vs. 29%, p = 0.07). Increased incidence of lung cancer was observed among single lung transplant (SLT) recipients for IPF (13 out of 97, 13.4%), with increased mortality compared to SLT for IPF without lung cancer (p = 0.028) during observational period. Conclusions Lung cancer is approximately 3.34 times more frequently diagnosed in IPF patients compared to general population, and associated with worse prognosis compared with IPF without lung cancer, with squamous cell carcinoma and lower lobe predilection. The causality between non-smoking IPF patients and lung cancer is to be determined.http://link.springer.com/article/10.1186/s12931-018-0899-4Idiopathic pulmonary fibrosisLung cancer |
| spellingShingle | Joo Heung Yoon Mehdi Nouraie Xiaoping Chen Richard H Zou Jacobo Sellares Kristen L Veraldi Jared Chiarchiaro Kathleen Lindell David O Wilson Naftali Kaminski Timothy Burns Humberto Trejo Bittar Samuel Yousem Kevin Gibson Daniel J Kass Characteristics of lung cancer among patients with idiopathic pulmonary fibrosis and interstitial lung disease – analysis of institutional and population data Respiratory Research Idiopathic pulmonary fibrosis Lung cancer |
| title | Characteristics of lung cancer among patients with idiopathic pulmonary fibrosis and interstitial lung disease – analysis of institutional and population data |
| title_full | Characteristics of lung cancer among patients with idiopathic pulmonary fibrosis and interstitial lung disease – analysis of institutional and population data |
| title_fullStr | Characteristics of lung cancer among patients with idiopathic pulmonary fibrosis and interstitial lung disease – analysis of institutional and population data |
| title_full_unstemmed | Characteristics of lung cancer among patients with idiopathic pulmonary fibrosis and interstitial lung disease – analysis of institutional and population data |
| title_short | Characteristics of lung cancer among patients with idiopathic pulmonary fibrosis and interstitial lung disease – analysis of institutional and population data |
| title_sort | characteristics of lung cancer among patients with idiopathic pulmonary fibrosis and interstitial lung disease analysis of institutional and population data |
| topic | Idiopathic pulmonary fibrosis Lung cancer |
| url | http://link.springer.com/article/10.1186/s12931-018-0899-4 |
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