Design, Synthesis, and Biological Evaluation of Pyridazinones Containing the (2-Fluorophenyl) Piperazine Moiety as Selective MAO-B Inhibitors

Design, Synthesis, and Biological Evaluation of Pyridazinones Containing the (2-Fluorophenyl) Piperazine Moiety as Selective MAO-B Inhibitors

Twelve pyridazinones (<b>T1</b>–<b>T12</b>) containing the (2-fluorophenyl) piperazine moiety were designed, synthesized, and evaluated for monoamine oxidase (MAO) -A and -B inhibitory activities. <b>T6</b> was found to be the most potent MAO-B inhibitor with an I...

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Bibliographic Details
Main Authors: Muhammed Çeçen, Jong Min Oh, Zeynep Özdemir, Saliha Ebru Büyüktuncel, Mehtap Uysal, Mohamed A. Abdelgawad, Arafa Musa, Nicola Gambacorta, Orazio Nicolotti, Bijo Mathew, Hoon Kim
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Molecules
Subjects:
monoamine oxidase
pyridazinone
kinetics
reversibility
ADME
molecular docking
Online Access:https://www.mdpi.com/1420-3049/25/22/5371

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https://www.mdpi.com/1420-3049/25/22/5371

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