The accuracy of computed tomography in the diagnosis of upper urinary tract urothelial carcinoma in correlation with the final histopathology: A retrospective study in 275 patients at a Tertiary Urology Institute
Introduction: Because the reports in the literature of radiologic investigations for upper tract urothelial cancer (UTUC) are limited by the number of patients, and included patients with different pathologies, we aimed to study the overall accuracy of computed tomography (CT) in the diagnosis of UT...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2021-01-01
|
| Series: | Urology Annals |
| Subjects: | |
| Online Access: | http://www.urologyannals.com/article.asp?issn=0974-7796;year=2021;volume=13;issue=4;spage=356;epage=361;aulast=Abouelkheir |
| _version_ | 1818985245731454976 |
|---|---|
| author | Rasha T Abouelkheir Mohamed Mohamed Elawdy Diaa Eldin Taha Mohamed Abd El-Hamid Yasser Osman Tarek El-Diasty |
| author_facet | Rasha T Abouelkheir Mohamed Mohamed Elawdy Diaa Eldin Taha Mohamed Abd El-Hamid Yasser Osman Tarek El-Diasty |
| author_sort | Rasha T Abouelkheir |
| collection | DOAJ |
| description | Introduction: Because the reports in the literature of radiologic investigations for upper tract urothelial cancer (UTUC) are limited by the number of patients, and included patients with different pathologies, we aimed to study the overall accuracy of computed tomography (CT) in the diagnosis of UTUC and their accuracy on predicting tumor location.
Methods: A retrospective review from 1990 to 2017 included patients who were treated for UTUC. Unenhanced CT scan was obtained first using Multi-Detector Computed Tomography (MDCT, Philips Medical Systems), then nonionic contrast medium, containing 350 mg iodine /ml was injected at 4 mL/s. Analysis was performed using SPSS®.
Results: Of 275 patients, complete data on CT was available on 270 (98%) patients. CT reported only two false positive and six false negative results and the overall accuracy was 96-97%. In comparison to the final pathological reports, CT /CTU detected 85% of the tumor location of in the renal pelvic and 50% of the calyceal tumors. In ureteric tumors, they detected distal (66/71= 93%) more than proximal ureteric tumors (60%).
Conclusion: In our cohort, CT/ CTU has a high overall accuracy (97%) in diagnosing UTUC, capability to well visualize tumors of distal ureter and renal pelvis, but could miss calyceal tumors. The matter to rely only on CT without ureteroscopic biopsy in the diagnosis of UTUC especially if radical surgery is planned needs further prospective studies. |
| first_indexed | 2024-12-20T18:31:50Z |
| format | Article |
| id | doaj.art-d9e65268e08c4fb29c9ae64e217c6935 |
| institution | Directory Open Access Journal |
| issn | 0974-7834 |
| language | English |
| last_indexed | 2024-12-20T18:31:50Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Urology Annals |
| spelling | doaj.art-d9e65268e08c4fb29c9ae64e217c69352022-12-21T19:30:01ZengWolters Kluwer Medknow PublicationsUrology Annals0974-78342021-01-0113435636110.4103/UA.UA_32_20The accuracy of computed tomography in the diagnosis of upper urinary tract urothelial carcinoma in correlation with the final histopathology: A retrospective study in 275 patients at a Tertiary Urology InstituteRasha T AbouelkheirMohamed Mohamed ElawdyDiaa Eldin TahaMohamed Abd El-HamidYasser OsmanTarek El-DiastyIntroduction: Because the reports in the literature of radiologic investigations for upper tract urothelial cancer (UTUC) are limited by the number of patients, and included patients with different pathologies, we aimed to study the overall accuracy of computed tomography (CT) in the diagnosis of UTUC and their accuracy on predicting tumor location. Methods: A retrospective review from 1990 to 2017 included patients who were treated for UTUC. Unenhanced CT scan was obtained first using Multi-Detector Computed Tomography (MDCT, Philips Medical Systems), then nonionic contrast medium, containing 350 mg iodine /ml was injected at 4 mL/s. Analysis was performed using SPSS®. Results: Of 275 patients, complete data on CT was available on 270 (98%) patients. CT reported only two false positive and six false negative results and the overall accuracy was 96-97%. In comparison to the final pathological reports, CT /CTU detected 85% of the tumor location of in the renal pelvic and 50% of the calyceal tumors. In ureteric tumors, they detected distal (66/71= 93%) more than proximal ureteric tumors (60%). Conclusion: In our cohort, CT/ CTU has a high overall accuracy (97%) in diagnosing UTUC, capability to well visualize tumors of distal ureter and renal pelvis, but could miss calyceal tumors. The matter to rely only on CT without ureteroscopic biopsy in the diagnosis of UTUC especially if radical surgery is planned needs further prospective studies.http://www.urologyannals.com/article.asp?issn=0974-7796;year=2021;volume=13;issue=4;spage=356;epage=361;aulast=Abouelkheircarcinoma transitional cellcomputed tomographyupper tract urothelial carcinomaupper urothelial cancer |
| spellingShingle | Rasha T Abouelkheir Mohamed Mohamed Elawdy Diaa Eldin Taha Mohamed Abd El-Hamid Yasser Osman Tarek El-Diasty The accuracy of computed tomography in the diagnosis of upper urinary tract urothelial carcinoma in correlation with the final histopathology: A retrospective study in 275 patients at a Tertiary Urology Institute Urology Annals carcinoma transitional cell computed tomography upper tract urothelial carcinoma upper urothelial cancer |
| title | The accuracy of computed tomography in the diagnosis of upper urinary tract urothelial carcinoma in correlation with the final histopathology: A retrospective study in 275 patients at a Tertiary Urology Institute |
| title_full | The accuracy of computed tomography in the diagnosis of upper urinary tract urothelial carcinoma in correlation with the final histopathology: A retrospective study in 275 patients at a Tertiary Urology Institute |
| title_fullStr | The accuracy of computed tomography in the diagnosis of upper urinary tract urothelial carcinoma in correlation with the final histopathology: A retrospective study in 275 patients at a Tertiary Urology Institute |
| title_full_unstemmed | The accuracy of computed tomography in the diagnosis of upper urinary tract urothelial carcinoma in correlation with the final histopathology: A retrospective study in 275 patients at a Tertiary Urology Institute |
| title_short | The accuracy of computed tomography in the diagnosis of upper urinary tract urothelial carcinoma in correlation with the final histopathology: A retrospective study in 275 patients at a Tertiary Urology Institute |
| title_sort | accuracy of computed tomography in the diagnosis of upper urinary tract urothelial carcinoma in correlation with the final histopathology a retrospective study in 275 patients at a tertiary urology institute |
| topic | carcinoma transitional cell computed tomography upper tract urothelial carcinoma upper urothelial cancer |
| url | http://www.urologyannals.com/article.asp?issn=0974-7796;year=2021;volume=13;issue=4;spage=356;epage=361;aulast=Abouelkheir |
| work_keys_str_mv | AT rashatabouelkheir theaccuracyofcomputedtomographyinthediagnosisofupperurinarytracturothelialcarcinomaincorrelationwiththefinalhistopathologyaretrospectivestudyin275patientsatatertiaryurologyinstitute AT mohamedmohamedelawdy theaccuracyofcomputedtomographyinthediagnosisofupperurinarytracturothelialcarcinomaincorrelationwiththefinalhistopathologyaretrospectivestudyin275patientsatatertiaryurologyinstitute AT diaaeldintaha theaccuracyofcomputedtomographyinthediagnosisofupperurinarytracturothelialcarcinomaincorrelationwiththefinalhistopathologyaretrospectivestudyin275patientsatatertiaryurologyinstitute AT mohamedabdelhamid theaccuracyofcomputedtomographyinthediagnosisofupperurinarytracturothelialcarcinomaincorrelationwiththefinalhistopathologyaretrospectivestudyin275patientsatatertiaryurologyinstitute AT yasserosman theaccuracyofcomputedtomographyinthediagnosisofupperurinarytracturothelialcarcinomaincorrelationwiththefinalhistopathologyaretrospectivestudyin275patientsatatertiaryurologyinstitute AT tarekeldiasty theaccuracyofcomputedtomographyinthediagnosisofupperurinarytracturothelialcarcinomaincorrelationwiththefinalhistopathologyaretrospectivestudyin275patientsatatertiaryurologyinstitute AT rashatabouelkheir accuracyofcomputedtomographyinthediagnosisofupperurinarytracturothelialcarcinomaincorrelationwiththefinalhistopathologyaretrospectivestudyin275patientsatatertiaryurologyinstitute AT mohamedmohamedelawdy accuracyofcomputedtomographyinthediagnosisofupperurinarytracturothelialcarcinomaincorrelationwiththefinalhistopathologyaretrospectivestudyin275patientsatatertiaryurologyinstitute AT diaaeldintaha accuracyofcomputedtomographyinthediagnosisofupperurinarytracturothelialcarcinomaincorrelationwiththefinalhistopathologyaretrospectivestudyin275patientsatatertiaryurologyinstitute AT mohamedabdelhamid accuracyofcomputedtomographyinthediagnosisofupperurinarytracturothelialcarcinomaincorrelationwiththefinalhistopathologyaretrospectivestudyin275patientsatatertiaryurologyinstitute AT yasserosman accuracyofcomputedtomographyinthediagnosisofupperurinarytracturothelialcarcinomaincorrelationwiththefinalhistopathologyaretrospectivestudyin275patientsatatertiaryurologyinstitute AT tarekeldiasty accuracyofcomputedtomographyinthediagnosisofupperurinarytracturothelialcarcinomaincorrelationwiththefinalhistopathologyaretrospectivestudyin275patientsatatertiaryurologyinstitute |