Glycogen Synthase Kinase 3 Inactivation Induces Cell Senescence through Sterol Regulatory Element Binding Protein 1-Mediated Lipogenesis in Chang Cells

Glycogen Synthase Kinase 3 Inactivation Induces Cell Senescence through Sterol Regulatory Element Binding Protein 1-Mediated Lipogenesis in Chang Cells

BackgroundEnhanced lipogenesis plays a critical role in cell senescence via induction of expression of the mature form of sterol regulatory element binding protein 1 (SREBP1), which contributes to an increase in organellar mass, one of the indicators of senescence. We investigated the molecular mech...

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Bibliographic Details
Main Authors: You-Mie Kim, Insun Song, Yong-Hak Seo, Gyesoon Yoon
Format: Article
Language:English
Published: Korean Endocrine Society 2013-12-01
Series:Endocrinology and Metabolism
Subjects:
Glycogen synthase kinase 3
Sterol regulatory element binding protein 1
Lipogenesis
Cell aging
Online Access:http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-28-297.pdf

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