Prevalence of Hepatitis B Virus, Human Immune Deficiency Virus and Associated Risk Factors Among Individuals with Presumptive Pulmonary Tuberculosis Attending at Saint Peter’s Specialized Hospital, Addis Ababa, Ethiopia
Kahasit Gebrehiwet,1,2 Endalkchew Biranu,2 Wondatir Nigatu,3 Atsbeha Gebreegziabher,4 Kassu Desta1 1Addis Ababa University College of Health Sciences, Department of Medical Laboratory Sciences, Addis Ababa, Ethiopia; 2St. Peter’s Specialized Hospital, Addis Ababa, Ethiopia; 3Ethiopian Public Health...
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| Format: | Article |
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Dove Medical Press
2023-06-01
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| Series: | Infection and Drug Resistance |
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| Online Access: | https://www.dovepress.com/prevalence-of-hepatitis-b-virus-human-immune-deficiency-virus-and-asso-peer-reviewed-fulltext-article-IDR |
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| author | Gebrehiwet K Biranu E Nigatu W Gebreegziabher A Desta K |
| author_facet | Gebrehiwet K Biranu E Nigatu W Gebreegziabher A Desta K |
| author_sort | Gebrehiwet K |
| collection | DOAJ |
| description | Kahasit Gebrehiwet,1,2 Endalkchew Biranu,2 Wondatir Nigatu,3 Atsbeha Gebreegziabher,4 Kassu Desta1 1Addis Ababa University College of Health Sciences, Department of Medical Laboratory Sciences, Addis Ababa, Ethiopia; 2St. Peter’s Specialized Hospital, Addis Ababa, Ethiopia; 3Ethiopian Public Health Institute, Tuberculosis /HIV Research Directorate, Addis Ababa, Ethiopia; 4Ethiopian Public Health Institute, Addis Ababa, EthiopiaCorrespondence: Endalkchew Biranu, Addis Ababa, Ethiopia, Tel +251-913186148, Email endalkalem16@gmail.com Kassu Desta, Addis Ababa University College of Health Sciences, Department of Medical Laboratory Sciences, Addis Ababa, Ethiopia, Tel +251911107099, Email Kassudesta2020@gmail.comBackground: Hepatitis B virus (HBV), human immunodeficiency virus (HIV) and tuberculosis are the causes of widely spread infectious disease, especially in resource-limited countries. The extent of HBV infection and its contributing factors among people with suspected pulmonary tuberculosis (PTB) were not adequately addressed.Objective: To assess the prevalence of HBV, HIV & their associated risk factors and the magnitude of TB among individuals with presumptive pulmonary tuberculosis attending at St. Peter’s Specialized Hospital, Addis Ababa, Ethiopia.Methods: A cross-sectional study was conducted among 387 individuals with presumptive PTB from October to December 2020. A standard questionnaire was used to collect socio-demographic data and associated risk factors. Sputum samples were analyzed by GeneXpert, Florescent Microscopy and Ziehl-Nelson staining technique. HBsAg test was carried out using Murex Version 3 ELISA test kit from serum/Plasma samples, HIV testing was performed by rapid HIV test kits and data were analyzed using SPSS version 23.Results: The mean age of study participants was 44.2 years. Overall, 14 (3.6%), 28 (7.2%) and 37 (9.6%) of them were positive for HBV, HIV & TB, respectively. Only single patient was HBV-HIV co-infected (0.3%). The TB-HIV co-infection was identified in 6 (1.6%). In multivariate analysis, being partner separated, alcohol consumption, body piercing and having multiple sexual partners were significantly associated with HBV infection. Having a spouse, who is divorced, widowed, sharing scissors, alcohol consumption and contact with multiple sexual partners also significantly associated with HIV infection.Conclusion: This study showed that HBV, HIV and TB are still public health issues that need awareness and health education on the risky behaviors and transmission of HBV, HIV & TB among individuals with presumptive TB suspects. Further large-scale study is necessary.Keywords: hepatitis B virus, human immunodeficiency virus, presumptive pulmonary tuberculosis |
| first_indexed | 2024-03-13T01:50:57Z |
| format | Article |
| id | doaj.art-d9e7127da7dd4e0bbfce5446a0643293 |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-03-13T01:50:57Z |
| publishDate | 2023-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-d9e7127da7dd4e0bbfce5446a06432932023-07-02T19:49:16ZengDove Medical PressInfection and Drug Resistance1178-69732023-06-01Volume 163965397984602Prevalence of Hepatitis B Virus, Human Immune Deficiency Virus and Associated Risk Factors Among Individuals with Presumptive Pulmonary Tuberculosis Attending at Saint Peter’s Specialized Hospital, Addis Ababa, EthiopiaGebrehiwet KBiranu ENigatu WGebreegziabher ADesta KKahasit Gebrehiwet,1,2 Endalkchew Biranu,2 Wondatir Nigatu,3 Atsbeha Gebreegziabher,4 Kassu Desta1 1Addis Ababa University College of Health Sciences, Department of Medical Laboratory Sciences, Addis Ababa, Ethiopia; 2St. Peter’s Specialized Hospital, Addis Ababa, Ethiopia; 3Ethiopian Public Health Institute, Tuberculosis /HIV Research Directorate, Addis Ababa, Ethiopia; 4Ethiopian Public Health Institute, Addis Ababa, EthiopiaCorrespondence: Endalkchew Biranu, Addis Ababa, Ethiopia, Tel +251-913186148, Email endalkalem16@gmail.com Kassu Desta, Addis Ababa University College of Health Sciences, Department of Medical Laboratory Sciences, Addis Ababa, Ethiopia, Tel +251911107099, Email Kassudesta2020@gmail.comBackground: Hepatitis B virus (HBV), human immunodeficiency virus (HIV) and tuberculosis are the causes of widely spread infectious disease, especially in resource-limited countries. The extent of HBV infection and its contributing factors among people with suspected pulmonary tuberculosis (PTB) were not adequately addressed.Objective: To assess the prevalence of HBV, HIV & their associated risk factors and the magnitude of TB among individuals with presumptive pulmonary tuberculosis attending at St. Peter’s Specialized Hospital, Addis Ababa, Ethiopia.Methods: A cross-sectional study was conducted among 387 individuals with presumptive PTB from October to December 2020. A standard questionnaire was used to collect socio-demographic data and associated risk factors. Sputum samples were analyzed by GeneXpert, Florescent Microscopy and Ziehl-Nelson staining technique. HBsAg test was carried out using Murex Version 3 ELISA test kit from serum/Plasma samples, HIV testing was performed by rapid HIV test kits and data were analyzed using SPSS version 23.Results: The mean age of study participants was 44.2 years. Overall, 14 (3.6%), 28 (7.2%) and 37 (9.6%) of them were positive for HBV, HIV & TB, respectively. Only single patient was HBV-HIV co-infected (0.3%). The TB-HIV co-infection was identified in 6 (1.6%). In multivariate analysis, being partner separated, alcohol consumption, body piercing and having multiple sexual partners were significantly associated with HBV infection. Having a spouse, who is divorced, widowed, sharing scissors, alcohol consumption and contact with multiple sexual partners also significantly associated with HIV infection.Conclusion: This study showed that HBV, HIV and TB are still public health issues that need awareness and health education on the risky behaviors and transmission of HBV, HIV & TB among individuals with presumptive TB suspects. Further large-scale study is necessary.Keywords: hepatitis B virus, human immunodeficiency virus, presumptive pulmonary tuberculosishttps://www.dovepress.com/prevalence-of-hepatitis-b-virus-human-immune-deficiency-virus-and-asso-peer-reviewed-fulltext-article-IDRhepatitis b virushuman immunodeficiency viruspresumptive pulmonary tuberculosis |
| spellingShingle | Gebrehiwet K Biranu E Nigatu W Gebreegziabher A Desta K Prevalence of Hepatitis B Virus, Human Immune Deficiency Virus and Associated Risk Factors Among Individuals with Presumptive Pulmonary Tuberculosis Attending at Saint Peter’s Specialized Hospital, Addis Ababa, Ethiopia Infection and Drug Resistance hepatitis b virus human immunodeficiency virus presumptive pulmonary tuberculosis |
| title | Prevalence of Hepatitis B Virus, Human Immune Deficiency Virus and Associated Risk Factors Among Individuals with Presumptive Pulmonary Tuberculosis Attending at Saint Peter’s Specialized Hospital, Addis Ababa, Ethiopia |
| title_full | Prevalence of Hepatitis B Virus, Human Immune Deficiency Virus and Associated Risk Factors Among Individuals with Presumptive Pulmonary Tuberculosis Attending at Saint Peter’s Specialized Hospital, Addis Ababa, Ethiopia |
| title_fullStr | Prevalence of Hepatitis B Virus, Human Immune Deficiency Virus and Associated Risk Factors Among Individuals with Presumptive Pulmonary Tuberculosis Attending at Saint Peter’s Specialized Hospital, Addis Ababa, Ethiopia |
| title_full_unstemmed | Prevalence of Hepatitis B Virus, Human Immune Deficiency Virus and Associated Risk Factors Among Individuals with Presumptive Pulmonary Tuberculosis Attending at Saint Peter’s Specialized Hospital, Addis Ababa, Ethiopia |
| title_short | Prevalence of Hepatitis B Virus, Human Immune Deficiency Virus and Associated Risk Factors Among Individuals with Presumptive Pulmonary Tuberculosis Attending at Saint Peter’s Specialized Hospital, Addis Ababa, Ethiopia |
| title_sort | prevalence of hepatitis b virus human immune deficiency virus and associated risk factors among individuals with presumptive pulmonary tuberculosis attending at saint peter rsquo s specialized hospital addis ababa ethiopia |
| topic | hepatitis b virus human immunodeficiency virus presumptive pulmonary tuberculosis |
| url | https://www.dovepress.com/prevalence-of-hepatitis-b-virus-human-immune-deficiency-virus-and-asso-peer-reviewed-fulltext-article-IDR |
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