Examination of the Reasons for Change in Treatment in Patients Infected with Human Immunodeficiency Virus
Introduction: Highly active antiretroviral therapy (HAART) has significantly reduced morbidity and mortality in patients infected with Human immunodeficiency virus (HIV). Despite this success, the sustainability of the initial treatment regimen has become difficult as patients continue the treatment...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Turkish |
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Galenos Yayinevi
2023-05-01
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| Series: | Mediterranean Journal of Infection, Microbes and Antimicrobials |
| Subjects: | |
| Online Access: | https://mjima.org/text.php?&id=362 |
| _version_ | 1797826802130878464 |
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| author | Mehmet ÇABALAK Tayibe BAL Eda Selin POLAT Sabahattin OCAK Yusuf ÖNLEN |
| author_facet | Mehmet ÇABALAK Tayibe BAL Eda Selin POLAT Sabahattin OCAK Yusuf ÖNLEN |
| author_sort | Mehmet ÇABALAK |
| collection | DOAJ |
| description | Introduction: Highly active antiretroviral therapy (HAART) has significantly reduced morbidity and mortality in patients infected with Human immunodeficiency virus (HIV). Despite this success, the sustainability of the initial treatment regimen has become difficult as patients continue the treatment for life. Highly active antiretroviral therapy regimen change may often be necessary due to intolerance/toxicity, pregnancy, comorbidities, difficulty in patient compliance and failure to achieve virological suppression. In this study, it was aimed to examine the reasons for HAART change in patients followed up for HIV/AIDS in Hatay Mustafa Kemal University, Tayfur Ata Sökmen Faculty of Medicine Hospital.
Materials and Methods: In this retrospective, cross-sectional, single-center study, 151 patients followed up at Hatay Mustafa Kemal University, Tayfur Ata Sökmen Medical Faculty Hospital for HIV between January 2018 and December 2020 were included in the study.
Results: One hundred-seventeen (77.5%) of the cases were male and 34 (22.5%) were female. The mean age was 39.08±14.2 years (20-83). Treatment changes were made in 35 (23.2%) of the cases. The most common reason for treatment change was intolerance/toxicity (19) in 12.6% of cases. Other reasons for change; pregnancy was six (4%), treatment non-compliance was four (2.6%), patient request was three (2%), and physician decision was three (2%). No drug changes were detected in the cases due to virological failure.
Conclusion: There is generally little data available in Turkey on the reasons for regime change in HIV patients using HAART. Therefore, the data we will obtain in this study can help draw a long-term plan for HAART drug management. |
| first_indexed | 2024-04-09T12:38:03Z |
| format | Article |
| id | doaj.art-d9e8ecc39d854cd39c88716bb629f8ce |
| institution | Directory Open Access Journal |
| issn | 2147-673X |
| language | Turkish |
| last_indexed | 2024-04-09T12:38:03Z |
| publishDate | 2023-05-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Mediterranean Journal of Infection, Microbes and Antimicrobials |
| spelling | doaj.art-d9e8ecc39d854cd39c88716bb629f8ce2023-05-15T08:44:11ZturGalenos YayineviMediterranean Journal of Infection, Microbes and Antimicrobials2147-673X2023-05-0112110.4274/mjima.galenos.2023.2022.2Examination of the Reasons for Change in Treatment in Patients Infected with Human Immunodeficiency VirusMehmet ÇABALAK0https://orcid.org/0000-0003-1148-2247Tayibe BAL1https://orcid.org/0000-0002-5315-122XEda Selin POLAT2https://orcid.org/0000-0002-6113-6281Sabahattin OCAK3https://orcid.org/0000-0002-8095-4378Yusuf ÖNLEN4https://orcid.org/0000-0002-8163-1368Hatay Mustafa Kemal University, Tayfur Ata Sökmen Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Hatay, TurkeyHatay Mustafa Kemal University, Tayfur Ata Sökmen Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Hatay, TurkeyHatay Mustafa Kemal University, Tayfur Ata Sökmen Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Hatay, TurkeyHatay Mustafa Kemal University, Tayfur Ata Sökmen Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Hatay, TurkeyHatay Mustafa Kemal University, Tayfur Ata Sökmen Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Hatay, TurkeyIntroduction: Highly active antiretroviral therapy (HAART) has significantly reduced morbidity and mortality in patients infected with Human immunodeficiency virus (HIV). Despite this success, the sustainability of the initial treatment regimen has become difficult as patients continue the treatment for life. Highly active antiretroviral therapy regimen change may often be necessary due to intolerance/toxicity, pregnancy, comorbidities, difficulty in patient compliance and failure to achieve virological suppression. In this study, it was aimed to examine the reasons for HAART change in patients followed up for HIV/AIDS in Hatay Mustafa Kemal University, Tayfur Ata Sökmen Faculty of Medicine Hospital. Materials and Methods: In this retrospective, cross-sectional, single-center study, 151 patients followed up at Hatay Mustafa Kemal University, Tayfur Ata Sökmen Medical Faculty Hospital for HIV between January 2018 and December 2020 were included in the study. Results: One hundred-seventeen (77.5%) of the cases were male and 34 (22.5%) were female. The mean age was 39.08±14.2 years (20-83). Treatment changes were made in 35 (23.2%) of the cases. The most common reason for treatment change was intolerance/toxicity (19) in 12.6% of cases. Other reasons for change; pregnancy was six (4%), treatment non-compliance was four (2.6%), patient request was three (2%), and physician decision was three (2%). No drug changes were detected in the cases due to virological failure. Conclusion: There is generally little data available in Turkey on the reasons for regime change in HIV patients using HAART. Therefore, the data we will obtain in this study can help draw a long-term plan for HAART drug management.https://mjima.org/text.php?&id=362hivhighly active antiretroviral therapychange in therapy |
| spellingShingle | Mehmet ÇABALAK Tayibe BAL Eda Selin POLAT Sabahattin OCAK Yusuf ÖNLEN Examination of the Reasons for Change in Treatment in Patients Infected with Human Immunodeficiency Virus Mediterranean Journal of Infection, Microbes and Antimicrobials hiv highly active antiretroviral therapy change in therapy |
| title | Examination of the Reasons for Change in Treatment in Patients Infected with Human Immunodeficiency Virus |
| title_full | Examination of the Reasons for Change in Treatment in Patients Infected with Human Immunodeficiency Virus |
| title_fullStr | Examination of the Reasons for Change in Treatment in Patients Infected with Human Immunodeficiency Virus |
| title_full_unstemmed | Examination of the Reasons for Change in Treatment in Patients Infected with Human Immunodeficiency Virus |
| title_short | Examination of the Reasons for Change in Treatment in Patients Infected with Human Immunodeficiency Virus |
| title_sort | examination of the reasons for change in treatment in patients infected with human immunodeficiency virus |
| topic | hiv highly active antiretroviral therapy change in therapy |
| url | https://mjima.org/text.php?&id=362 |
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