How small-molecule inhibitors of dengue-virus infection interfere with viral membrane fusion

How small-molecule inhibitors of dengue-virus infection interfere with viral membrane fusion

Dengue virus (DV) is a compact, icosahedrally symmetric, enveloped particle, covered by 90 dimers of envelope protein (E), which mediates viral attachment and membrane fusion. Fusion requires a dimer-to-trimer transition and membrane engagement of hydrophobic ‘fusion loops’. We previously characteri...

Full description

Bibliographic Details
Main Authors:	Luke H Chao, Jaebong Jang, Adam Johnson, Anthony Nguyen, Nathanael S Gray, Priscilla L Yang, Stephen C Harrison
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2018-07-01
Series:	eLife
Subjects:	virus entry flavivirus inhibitor mechanism
Online Access:	https://elifesciences.org/articles/36461

Similar Items

A Sensitive Yellow Fever Virus Entry Reporter Identifies Valosin-Containing Protein (VCP/p97) as an Essential Host Factor for Flavivirus Uncoating
by: Harish N. Ramanathan, et al.
Published: (2020-04-01)

New treatment strategies for dengue and other flaviviral diseases
Published: (2006)

A Sensitive Yellow Fever Virus Entry Reporter Identifies Valosin-Containing Protein (VCP/p97) as an Essential Host Factor for Flavivirus Uncoating
by: Shuo Zhang, et al.
Published: (2020-08-01)

Molecular detection of mixed infections with multiple dengue virus serotypes in suspected dengue samples in Tamaulipas, Mexico
by: Rocío Requena-Castro, et al.

Identification of small molecules capable of enhancing viral membrane fusion
by: Mª Jesús García-Murria, et al.
Published: (2023-05-01)

Human Claudin-Derived Peptides Block the Membrane Fusion Process of Zika Virus and Are Broad Flavivirus Inhibitors
by: Jim Zoladek, et al.
Published: (2022-10-01)

Mucolipin-2 Cation Channel Increases Trafficking Efficiency of Endocytosed Viruses
by: Nicholas Rinkenberger, et al.
Published: (2018-03-01)

Synergistic Internal Ribosome Entry Site/MicroRNA-Based Approach for Flavivirus Attenuation and Live Vaccine Development
by: Konstantin A. Tsetsarkin, et al.
Published: (2017-05-01)

Polarization of Type 1 Macrophages Is Associated with the Severity of Viral Encephalitis Caused by Japanese Encephalitis Virus and Dengue Virus
by: Ming-Kai Jhan, et al.
Published: (2021-11-01)

Optimization of 4-Anilinoquinolines as Dengue Virus Inhibitors
by: Pei-Tzu Huang, et al.
Published: (2021-12-01)

Innovative and New Approaches to Laboratory Diagnosis of Zika and Dengue: A Meeting Report
by: Goncalves, Adriana, et al.
Published: (2018)

Sophoraflavenone G Restricts Dengue and Zika Virus Infection via RNA Polymerase Interference
by: Alexandre Sze, et al.
Published: (2017-10-01)

Fundus Findings in Dengue Fever: A Case Report
by: Berna Şahan, et al.
Published: (2015-10-01)

Early Events in Japanese Encephalitis Virus Infection: Viral Entry
by: Sang-Im Yun, et al.
Published: (2018-08-01)

Sequential conformational rearrangements in flavivirus membrane fusion
by: Luke H Chao, et al.
Published: (2014-12-01)

Two RNA tunnel inhibitors bind in highly conserved sites in dengue virus NS5 polymerase : structural and functional studies
by: Arora, Rishi, et al.
Published: (2021)

Flavivirus cross-reactivity to dengue nonstructural protein 1 antigen detection assays
by: Tan, Li Kiang, et al.
Published: (2021)

DENGUE: A PERSISTENT DISEASE IN ALL THE YEAR
by: Aray-Andrade María Mercedes, et al.
Published: (2015-01-01)

Identification and characterization of key residues in Zika virus envelope protein for virus assembly and entry
by: Xiao Ma, et al.
Published: (2022-12-01)

Identification of Broad-Spectrum Antiviral Compounds by Targeting Viral Entry
by: Michela Mazzon, et al.
Published: (2019-02-01)

Molecular virology and control of flaviviruses /
by: Shi, Pei-Yong, editor
Published: (c201)

Previous dengue or Zika virus exposure can drive to infection enhancement or neutralisation of other flaviviruses
by: Renato AS Oliveira, et al.

Novel differential linear B‐cell epitopes to identify Zika and dengue virus infections in patients
by: Siti Naqiah Amrun, et al.
Published: (2019)

Novel differential linear B‐cell epitopes to identify Zika and dengue virus infections in patients
by: Siti Naqiah Amrun, et al.
Published: (2019-01-01)

Interferon-stimulated gene PVRL4 broadly suppresses viral entry by inhibiting viral-cellular membrane fusion
by: Qiaomei Cai, et al.
Published: (2024-02-01)

The Burden of Dengue and Chikungunya Worldwide: Implications for the Southern United States and California
by: Anthony C. Fredericks, et al.
Published: (2015-05-01)

An equine iPSC-based phenotypic screening platform identifies pro- and anti-viral molecules against West Nile virus
by: Marielle Cochet, et al.
Published: (2024-03-01)

HIV-1 Entry and Membrane Fusion Inhibitors
by: Tianshu Xiao, et al.
Published: (2021-04-01)

Concurrent dengue and malaria in the Amazon region Co-infecção por dengue e malária na região Amazônica
by: Vinícius dos Santos Santana, et al.
Published: (2010-10-01)

Dengue: An Analysis of Epidemiological Pattern Over a Six Year Period
by: Nidhi Singla, et al.
Published: (2016-12-01)

Dengue Virus Non-Structural Protein 5
by: Abbas El Sahili, et al.
Published: (2017-04-01)

The Envelope Residues E152/156/158 of Zika Virus Influence the Early Stages of Virus Infection in Human Cells
by: Sandra Bos, et al.
Published: (2019-11-01)

Using bioinformatics tools for the discovery of Dengue RNA-dependent RNA polymerase inhibitors
by: Nomagugu B. Nncube, et al.
Published: (2018-09-01)

Different Cross-Reactivities of IgM Responses in Dengue, Zika and Tick-Borne Encephalitis Virus Infections
by: Karin Stiasny, et al.
Published: (2021-03-01)

Morphological Diversity and Dynamics of Dengue Virus Affecting Antigenicity
by: Guntur Fibriansah, et al.
Published: (2021-07-01)

Contribution of phylogenetics to understanding the evolution and epidemiology of dengue virus
by: Xi Yu, et al.
Published: (2022-10-01)

Structure and flexibility of non-structural proteins 3 and -5 of Dengue- and Zika viruses in solution
by: Saw, Wuan Geok, et al.
Published: (2020)

Viral Hijacking of BET Proteins
by: Irene P. Chen, et al.
Published: (2022-10-01)

A Retrospective Study of Paediatric Dengue Cases in a Tertiary Care Hospital in Southern India
by: Padmanabhan P Athira, et al.
Published: (2018-07-01)

Prolonged persistence of IgM against dengue virus detected by commonly used commercial assays
by: Yu-Wen Chien, et al.
Published: (2018-04-01)