Tumor-Educated Platelet Extracellular Vesicles: Proteomic Profiling and Crosstalk with Colorectal Cancer Cells

Tumor-Educated Platelet Extracellular Vesicles: Proteomic Profiling and Crosstalk with Colorectal Cancer Cells

Background: Platelet–cancer cell interactions modulate tumor metastasis and thrombosis in cancer. Platelet-derived extracellular vesicles (EVs) can contribute to these outcomes. Methods: We characterized the medium-sized EVs (mEVs) released by thrombin-stimulated platelets of colorectal cancer (CRC)...

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Bibliographic Details
Main Authors: Annalisa Contursi, Rosa Fullone, Paulina Szklanna-Koszalinska, Simone Marcone, Paola Lanuti, Francesco Taus, Alessandra Meneguzzi, Giulia Turri, Melania Dovizio, Annalisa Bruno, Corrado Pedrazzani, Stefania Tacconelli, Marco Marchisio, Patrizia Ballerini, Pietro Minuz, Patricia Maguire, Paola Patrignani
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Cancers
Subjects:
epithelial-mesenchymal transition
cyclooxygenase-2
thromboxane A<sub>2</sub>
platelet-derived extracellular vesicles
colorectal cancer
Online Access:https://www.mdpi.com/2072-6694/15/2/350

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