IQCN disruption causes fertilization failure and male infertility due to manchette assembly defect

IQCN disruption causes fertilization failure and male infertility due to manchette assembly defect

Abstract Total fertilization failure (TFF) is an important cause of infertility; however, the genetic basis of TFF caused by male factors remains to be clarified. In this study, whole‐exome sequencing was firstly used to screen for genetic causes of TFF after intracytoplasmic sperm injection (ICSI),...

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Bibliographic Details
Main Authors: Jing Dai, Qi Li, Qinwei Zhou, Shen Zhang, Junru Chen, Yize Wang, Jing Guo, Yifan Gu, Fei Gong, Yueqiu Tan, Guangxiu Lu, Wei Zheng, Ge Lin
Format: Article
Language:English
Published: Springer Nature 2022-12-01
Series:EMBO Molecular Medicine
Subjects:
calmodulin
fertilization failure
IQCN
manchette
PLCζ
Online Access:https://doi.org/10.15252/emmm.202216501

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