PHF6 recruits BPTF to promote HIF-dependent pathway and progression in YAP-high breast cancer

PHF6 recruits BPTF to promote HIF-dependent pathway and progression in YAP-high breast cancer

Abstract Background Aberrant epigenetic remodeling events contribute to progression and metastasis of breast cancer (Bca). The specific mechanims that epigenetic factors rely on to mediate tumor aggressiveness remain unclear. We aimed to elucidate the roles of epigenetic protein PHF6 in breast tumor...

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Bibliographic Details
Main Authors: Sheng Gao, Wensheng Zhang, Jingjing Ma, Xiaojian Ni
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Journal of Translational Medicine
Subjects:
PHF6
BPTF
HIF
Epigenetic remodeling
Breast cancer
Online Access:https://doi.org/10.1186/s12967-023-04031-8

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