Association of NAT2 genetic polymorphism with the efficacy of Neurotropin® for the enhancement of aggrecan gene expression in nucleus pulposus cells: a pilot study

Association of NAT2 genetic polymorphism with the efficacy of Neurotropin® for the enhancement of aggrecan gene expression in nucleus pulposus cells: a pilot study

Abstract Background Intervertebral disc degeneration, one of the major causes of low-back pain, results from altered biosynthesis/turnover of extracellular matrix in the disc. Previously, we reported that the analgesic drug Neurotropin® (NTP) had an anabolic effect on glycosaminoglycan synthesis in...

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Bibliographic Details
Main Authors: Tomoko Nakai, Daisuke Sakai, Yoshihiko Nakamura, Natsumi Horikita, Erika Matsushita, Mitsuru Naiki, Masahiko Watanabe
Format: Article
Language:English
Published: BMC 2021-03-01
Series:BMC Medical Genomics
Subjects:
Polymorphism
NAT2
Rapid/intermediate acetylator
Nucleus pulposus cells
Intervertebral discs
Aggrecan
Online Access:https://doi.org/10.1186/s12920-021-00926-x

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