Kaempferia galanga L.: Progresses in Phytochemistry, Pharmacology, Toxicology and Ethnomedicinal Uses
K. galanga is an aromatic medicinal herb. It is locally to India and distributed in China, Myanmar, Indonesia, Malaysia, and Thailand. K. galanga is a Traditional Chinese Herb Medicine (TCHM), which has been applied to treat cold, dry cough, toothaches, rheumatism, hypertension and so on. In additio...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-10-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.675350/full |
| _version_ | 1818355847715094528 |
|---|---|
| author | Si-Yu Wang Si-Yu Wang Hui Zhao Hong-Tao Xu Xiao-Dong Han Yun-Shan Wu Yun-Shan Wu Fang-Fang Xu Fang-Fang Xu Xiao-Bo Yang Xiao-Bo Yang Xiao-Bo Yang Ulf Göransson Bo Liu Bo Liu Bo Liu Bo Liu |
| author_facet | Si-Yu Wang Si-Yu Wang Hui Zhao Hong-Tao Xu Xiao-Dong Han Yun-Shan Wu Yun-Shan Wu Fang-Fang Xu Fang-Fang Xu Xiao-Bo Yang Xiao-Bo Yang Xiao-Bo Yang Ulf Göransson Bo Liu Bo Liu Bo Liu Bo Liu |
| author_sort | Si-Yu Wang |
| collection | DOAJ |
| description | K. galanga is an aromatic medicinal herb. It is locally to India and distributed in China, Myanmar, Indonesia, Malaysia, and Thailand. K. galanga is a Traditional Chinese Herb Medicine (TCHM), which has been applied to treat cold, dry cough, toothaches, rheumatism, hypertension and so on. In addition, it has been used widely as spices since its highly aromas. The aim of this review is to compile and update the current progresses of ethnomedicinal uses, phytochemistry, pharmacology and toxicology of K. galanga. All the data on K. galanga were based on different classical literary works, multiple electronic databases including SciFinder, Web of Science, PubMed, etc. The results showed that ninety-seven compounds have been identified from rhizome of K. galanga, including terpenoids, phenolics, cyclic dipeptides, flavonoids, diarylheptanoids, fatty acids and esters. Modern pharmacology studies revealed that extracts or secondary metabolites of the herb possessed anti-inflammatory, anti-oxidant, anti-tumorous, anti-bacterial, and anti-angiogenesis effects, which were closely related to its abundant ethnomedicinal uses. In conclusion, although previous research works have provided various information of K. galanga, more in-depth studies are still necessary to systemically evaluate phytochemistry, pharmacological activities, toxicity and quality control of this herb. |
| first_indexed | 2024-12-13T19:47:50Z |
| format | Article |
| id | doaj.art-d9ee216783f644728146c149c8c00fbf |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-13T19:47:50Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-d9ee216783f644728146c149c8c00fbf2022-12-21T23:33:31ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-10-011210.3389/fphar.2021.675350675350Kaempferia galanga L.: Progresses in Phytochemistry, Pharmacology, Toxicology and Ethnomedicinal UsesSi-Yu Wang0Si-Yu Wang1Hui Zhao2Hong-Tao Xu3Xiao-Dong Han4Yun-Shan Wu5Yun-Shan Wu6Fang-Fang Xu7Fang-Fang Xu8Xiao-Bo Yang9Xiao-Bo Yang10Xiao-Bo Yang11Ulf Göransson12Bo Liu13Bo Liu14Bo Liu15Bo Liu16The Second Clinical Medical College, and Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou, ChinaGuangzhou Key Laboratory of Chirality Research on Active Components of Traditional Chinese Medicine, Guangzhou, ChinaCollege of Basic Medical Science, Guangzhou University of Chinese Medicine, Guangzhou, ChinaShanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, ChinaThe Second Clinical Medical College, and Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou, ChinaThe Second Clinical Medical College, and Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou, ChinaGuangzhou Key Laboratory of Chirality Research on Active Components of Traditional Chinese Medicine, Guangzhou, ChinaThe Second Clinical Medical College, and Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou, ChinaGuangzhou Key Laboratory of Chirality Research on Active Components of Traditional Chinese Medicine, Guangzhou, ChinaThe Second Clinical Medical College, and Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou, ChinaState Key Laboratory of Dampness Syndrome of Chinese Medicine, Guangzhou, ChinaGuangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research, Guangzhou University of Chinese Medicine, Guangzhou, ChinaDivision of Pharmacognosy, Biomedical Center, Uppsala University, Uppsala, SwedenThe Second Clinical Medical College, and Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou, ChinaGuangzhou Key Laboratory of Chirality Research on Active Components of Traditional Chinese Medicine, Guangzhou, ChinaState Key Laboratory of Dampness Syndrome of Chinese Medicine, Guangzhou, ChinaGuangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research, Guangzhou University of Chinese Medicine, Guangzhou, ChinaK. galanga is an aromatic medicinal herb. It is locally to India and distributed in China, Myanmar, Indonesia, Malaysia, and Thailand. K. galanga is a Traditional Chinese Herb Medicine (TCHM), which has been applied to treat cold, dry cough, toothaches, rheumatism, hypertension and so on. In addition, it has been used widely as spices since its highly aromas. The aim of this review is to compile and update the current progresses of ethnomedicinal uses, phytochemistry, pharmacology and toxicology of K. galanga. All the data on K. galanga were based on different classical literary works, multiple electronic databases including SciFinder, Web of Science, PubMed, etc. The results showed that ninety-seven compounds have been identified from rhizome of K. galanga, including terpenoids, phenolics, cyclic dipeptides, flavonoids, diarylheptanoids, fatty acids and esters. Modern pharmacology studies revealed that extracts or secondary metabolites of the herb possessed anti-inflammatory, anti-oxidant, anti-tumorous, anti-bacterial, and anti-angiogenesis effects, which were closely related to its abundant ethnomedicinal uses. In conclusion, although previous research works have provided various information of K. galanga, more in-depth studies are still necessary to systemically evaluate phytochemistry, pharmacological activities, toxicity and quality control of this herb.https://www.frontiersin.org/articles/10.3389/fphar.2021.675350/fullKaempferia galanga L.ethnomedicinal usesphytochemistrypharmacologytoxicology |
| spellingShingle | Si-Yu Wang Si-Yu Wang Hui Zhao Hong-Tao Xu Xiao-Dong Han Yun-Shan Wu Yun-Shan Wu Fang-Fang Xu Fang-Fang Xu Xiao-Bo Yang Xiao-Bo Yang Xiao-Bo Yang Ulf Göransson Bo Liu Bo Liu Bo Liu Bo Liu Kaempferia galanga L.: Progresses in Phytochemistry, Pharmacology, Toxicology and Ethnomedicinal Uses Frontiers in Pharmacology Kaempferia galanga L. ethnomedicinal uses phytochemistry pharmacology toxicology |
| title | Kaempferia galanga L.: Progresses in Phytochemistry, Pharmacology, Toxicology and Ethnomedicinal Uses |
| title_full | Kaempferia galanga L.: Progresses in Phytochemistry, Pharmacology, Toxicology and Ethnomedicinal Uses |
| title_fullStr | Kaempferia galanga L.: Progresses in Phytochemistry, Pharmacology, Toxicology and Ethnomedicinal Uses |
| title_full_unstemmed | Kaempferia galanga L.: Progresses in Phytochemistry, Pharmacology, Toxicology and Ethnomedicinal Uses |
| title_short | Kaempferia galanga L.: Progresses in Phytochemistry, Pharmacology, Toxicology and Ethnomedicinal Uses |
| title_sort | kaempferia galanga l progresses in phytochemistry pharmacology toxicology and ethnomedicinal uses |
| topic | Kaempferia galanga L. ethnomedicinal uses phytochemistry pharmacology toxicology |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2021.675350/full |
| work_keys_str_mv | AT siyuwang kaempferiagalangalprogressesinphytochemistrypharmacologytoxicologyandethnomedicinaluses AT siyuwang kaempferiagalangalprogressesinphytochemistrypharmacologytoxicologyandethnomedicinaluses AT huizhao kaempferiagalangalprogressesinphytochemistrypharmacologytoxicologyandethnomedicinaluses AT hongtaoxu kaempferiagalangalprogressesinphytochemistrypharmacologytoxicologyandethnomedicinaluses AT xiaodonghan kaempferiagalangalprogressesinphytochemistrypharmacologytoxicologyandethnomedicinaluses AT yunshanwu kaempferiagalangalprogressesinphytochemistrypharmacologytoxicologyandethnomedicinaluses AT yunshanwu kaempferiagalangalprogressesinphytochemistrypharmacologytoxicologyandethnomedicinaluses AT fangfangxu kaempferiagalangalprogressesinphytochemistrypharmacologytoxicologyandethnomedicinaluses AT fangfangxu kaempferiagalangalprogressesinphytochemistrypharmacologytoxicologyandethnomedicinaluses AT xiaoboyang kaempferiagalangalprogressesinphytochemistrypharmacologytoxicologyandethnomedicinaluses AT xiaoboyang kaempferiagalangalprogressesinphytochemistrypharmacologytoxicologyandethnomedicinaluses AT xiaoboyang kaempferiagalangalprogressesinphytochemistrypharmacologytoxicologyandethnomedicinaluses AT ulfgoransson kaempferiagalangalprogressesinphytochemistrypharmacologytoxicologyandethnomedicinaluses AT boliu kaempferiagalangalprogressesinphytochemistrypharmacologytoxicologyandethnomedicinaluses AT boliu kaempferiagalangalprogressesinphytochemistrypharmacologytoxicologyandethnomedicinaluses AT boliu kaempferiagalangalprogressesinphytochemistrypharmacologytoxicologyandethnomedicinaluses AT boliu kaempferiagalangalprogressesinphytochemistrypharmacologytoxicologyandethnomedicinaluses |