Contribution of PNPLA3 gene polymorphisms to hepatocellular carcinoma susceptibility in the Chinese Han population
Abstract Objectives The purpose of this study was to investigate the association of PNPLA3 single nucleotide polymorphisms (SNPs) (rs738409 C > G, rs3747207 G > A, rs4823173 G > A, and rs2896019 T > G) with hepatocellular carcinoma (HCC) susceptibility. Methods This case–control study in...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | BMC Medical Genomics |
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| Online Access: | https://doi.org/10.1186/s12920-022-01394-7 |
| _version_ | 1811310819749658624 |
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| author | Dongwei Gong Shizong Li Zhiwei Yu Kaiqiong Wang Xin Qiao Changxiong Wu |
| author_facet | Dongwei Gong Shizong Li Zhiwei Yu Kaiqiong Wang Xin Qiao Changxiong Wu |
| author_sort | Dongwei Gong |
| collection | DOAJ |
| description | Abstract Objectives The purpose of this study was to investigate the association of PNPLA3 single nucleotide polymorphisms (SNPs) (rs738409 C > G, rs3747207 G > A, rs4823173 G > A, and rs2896019 T > G) with hepatocellular carcinoma (HCC) susceptibility. Methods This case–control study included 484 HCC patients and 487 controls. Logistic regression analysis was performed to study the associations of PNPLA3 gene polymorphisms with HCC susceptibility, and odds ratios with their corresponding 95% confidence intervals were calculated to evaluate these correlations. Results In the overall analysis, we found that the G allele (OR = 1.25, 95% CI = 1.04–1.50, p = 0.018, false discovery rate (FDR)-p = 0.035) and GG genotype (OR = 1.59, 95% CI = 1.06–2.39, p = 0.024, FDR-p = 0.048) of rs2896019 were significantly associated with increased HCC susceptibility. In stratified analysis, we found that all four SNPs were related to increased HCC susceptibility in subjects aged > 55 years. In haplotype analysis, the GAAG haplotype was significantly associated with increased HCC susceptibility (OR = 1.25, 95% CI = 1.03–1.53, p = 0.023, FDR-p = 0.046). Besides, we noticed that rs738409 was significantly correlated with alpha-fetoprotein (AFP) (p = 0.007), and HCC patients with the GG genotype had a higher level of AFP. Conclusions Our study suggested that PNPLA3-rs2896019 was significantly associated with an increased susceptibility to HCC. |
| first_indexed | 2024-04-13T10:06:51Z |
| format | Article |
| id | doaj.art-d9f0c95c84664843b24706b2dff90b32 |
| institution | Directory Open Access Journal |
| issn | 1755-8794 |
| language | English |
| last_indexed | 2024-04-13T10:06:51Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Genomics |
| spelling | doaj.art-d9f0c95c84664843b24706b2dff90b322022-12-22T02:51:05ZengBMCBMC Medical Genomics1755-87942022-11-0115111010.1186/s12920-022-01394-7Contribution of PNPLA3 gene polymorphisms to hepatocellular carcinoma susceptibility in the Chinese Han populationDongwei Gong0Shizong Li1Zhiwei Yu2Kaiqiong Wang3Xin Qiao4Changxiong Wu5Hepatopancreatobiliary Surgery, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical UniversityHepatopancreatobiliary Surgery, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical UniversityHepatopancreatobiliary Surgery, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical UniversityHepatopancreatobiliary Surgery, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical UniversityHepatopancreatobiliary Surgery, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical UniversityHepatopancreatobiliary Surgery, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical UniversityAbstract Objectives The purpose of this study was to investigate the association of PNPLA3 single nucleotide polymorphisms (SNPs) (rs738409 C > G, rs3747207 G > A, rs4823173 G > A, and rs2896019 T > G) with hepatocellular carcinoma (HCC) susceptibility. Methods This case–control study included 484 HCC patients and 487 controls. Logistic regression analysis was performed to study the associations of PNPLA3 gene polymorphisms with HCC susceptibility, and odds ratios with their corresponding 95% confidence intervals were calculated to evaluate these correlations. Results In the overall analysis, we found that the G allele (OR = 1.25, 95% CI = 1.04–1.50, p = 0.018, false discovery rate (FDR)-p = 0.035) and GG genotype (OR = 1.59, 95% CI = 1.06–2.39, p = 0.024, FDR-p = 0.048) of rs2896019 were significantly associated with increased HCC susceptibility. In stratified analysis, we found that all four SNPs were related to increased HCC susceptibility in subjects aged > 55 years. In haplotype analysis, the GAAG haplotype was significantly associated with increased HCC susceptibility (OR = 1.25, 95% CI = 1.03–1.53, p = 0.023, FDR-p = 0.046). Besides, we noticed that rs738409 was significantly correlated with alpha-fetoprotein (AFP) (p = 0.007), and HCC patients with the GG genotype had a higher level of AFP. Conclusions Our study suggested that PNPLA3-rs2896019 was significantly associated with an increased susceptibility to HCC.https://doi.org/10.1186/s12920-022-01394-7PNPLA3PolymorphismHepatocellular carcinomaSusceptibilityChinese Han population |
| spellingShingle | Dongwei Gong Shizong Li Zhiwei Yu Kaiqiong Wang Xin Qiao Changxiong Wu Contribution of PNPLA3 gene polymorphisms to hepatocellular carcinoma susceptibility in the Chinese Han population BMC Medical Genomics PNPLA3 Polymorphism Hepatocellular carcinoma Susceptibility Chinese Han population |
| title | Contribution of PNPLA3 gene polymorphisms to hepatocellular carcinoma susceptibility in the Chinese Han population |
| title_full | Contribution of PNPLA3 gene polymorphisms to hepatocellular carcinoma susceptibility in the Chinese Han population |
| title_fullStr | Contribution of PNPLA3 gene polymorphisms to hepatocellular carcinoma susceptibility in the Chinese Han population |
| title_full_unstemmed | Contribution of PNPLA3 gene polymorphisms to hepatocellular carcinoma susceptibility in the Chinese Han population |
| title_short | Contribution of PNPLA3 gene polymorphisms to hepatocellular carcinoma susceptibility in the Chinese Han population |
| title_sort | contribution of pnpla3 gene polymorphisms to hepatocellular carcinoma susceptibility in the chinese han population |
| topic | PNPLA3 Polymorphism Hepatocellular carcinoma Susceptibility Chinese Han population |
| url | https://doi.org/10.1186/s12920-022-01394-7 |
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