AKR1C3 expression in T acute lymphoblastic leukemia/lymphoma for clinical use as a biomarker

AKR1C3 expression in T acute lymphoblastic leukemia/lymphoma for clinical use as a biomarker

Abstract To investigate aldo–keto reductase 1C3 (AKR1C3) expression in T and B acute lymphoblastic leukemia/lymphoma (ALL) patients. Three commercial antibodies were evaluated for AKR1C3 immunohistochemistry (IHC) staining performance: Polyclonal Thermofisher scientific (Clone#PA523667), rabbit mono...

Full description

Bibliographic Details
Main Authors:	Deepti Reddi, Brandon W. Seaton, David Woolston, Lauri Aicher, Luke D. Monroe, Zhengwei J. Mao, Jill C. Harrell, Jerald P. Radich, Anjali Advani, Nikolaos Papadantonakis, Cecilia C. S. Yeung
Format:	Article
Language:	English
Published:	Nature Portfolio 2022-04-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-022-09697-6

Similar Items

Mutational profiling in acute lymphoblastic leukemia by RNA sequencing and chromosomal genomic array testing
by: Cecilia Yeung, et al.
Published: (2021-08-01)

Early precursor T-cell acute lymphoblastic leukemia: current paradigms and evolving concepts
by: Omar Castaneda Puglianini, et al.
Published: (2020-06-01)

Enzymes of the AKR1B and AKR1C subfamilies and uterine diseases
by: Tea eLanisnik Rizner
Published: (2012-03-01)

Solving the mystery of myelodysplasia.
by: Jerald Radich
Published: (2008-02-01)

Structure-activity relationships of human AKR-type oxidoreductases involved in bile acid synthesis: AKR1D1 and AKR1C4.
by: Lee, W, et al.
Published: (2009)

Structure-activity relationships of human AKR-type oxidoreductases involved in bile acid synthesis: AKR1D1 and AKR1C4.
by: Lee, W, et al.
Published: (2009)

AKR1B1 and AKR1B10 as Prognostic Biomarkers of Endometrioid Endometrial Carcinomas
by: Marko Hojnik, et al.
Published: (2021-07-01)

Expression of the Aldo-Keto Reductases AKR1B1 and AKR1B10 in Human Cancers.
by: Brian eLaffin, et al.
Published: (2012-06-01)

Roles of AKR1C3 in malignancy
by: Xin-Zhu Xiao, et al.
Published: (2021-05-01)

Current Use of Asparaginase in Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma
by: Luke Maese, et al.
Published: (2022-06-01)

Ruthenium complexes show potent inhibition of AKR1C1, AKR1C2, and AKR1C3 enzymes and anti-proliferative action against chemoresistant ovarian cancer cell line
by: Jakob Kljun, et al.
Published: (2022-08-01)

In-silico Investigations of quinine and quinidine as potential Inhibitors of AKR1B1 and AKR1B10: Functional and structural characterization.
by: Syeda Abida Ejaz, et al.
Published: (2022-01-01)

The Role of AKR1B10 in Physiology and Pathophysiology
by: Satoshi Endo, et al.
Published: (2021-05-01)

Pleiotropic Actions of Aldehyde Reductase (AKR1A)
by: Junichi Fujii, et al.
Published: (2021-05-01)

Aldo-keto reductase (AKR) superfamily: Genomics and annotation
by: Mindnich Rebekka D, et al.
Published: (2009-07-01)

Modeling single nucleotide polymorphisms in the human AKR1C1 and AKR1C2 genes: implications for functional and genotyping analyses.
by: Jonathan W Arthur, et al.
Published: (2010-12-01)

Human and murine steroid 5β-reductases (AKR1D1 and AKR1D4): Insights into the role of the catalytic glutamic acid
by: Chen, M, et al.
Published: (2019)

Unravelling the role of AKR1D1 in human hepatocytes
by: Nikolaou, N
Published: (2017)

AKR2A is involved in the flowering process of Arabidopsis thaliana
by: Qian Tang, et al.
Published: (2022-12-01)

EXPERIMENTAL DETERMINATION OF THE ZERO POWER TRANSFER FUNCTION OF THE AKR-2
by: Hübner Sebastian, et al.
Published: (2021-01-01)

Electrostatic shock properties inferred from AKR fine structure
by: R. Pottelette, et al.
Published: (2003-01-01)

Analogues of Natural Chalcones as Efficient Inhibitors of AKR1C3
by: Gabriele Möller, et al.
Published: (2022-01-01)

Prevalence and Associated Factors with Attending Antenatal Care in Akre City, Iraq
by: Bnar Mustafa Ahmed, et al.
Published: (2023-05-01)

Assessment of Job Stress among Nurses Working in Akre Teaching Hospitals
by: Mohanned Khaleel Abdullah, et al.
Published: (2018-03-01)

Clinical and pharmacologic aspects of blinatumomab in the treatment of B-cell acute lymphoblastic leukemia
by: Portell CA, et al.
Published: (2013-04-01)

Transcriptomic Profiling Reveals AKR1C1 and AKR1C3 Mediate Cisplatin Resistance in Signet Ring Cell Gastric Carcinoma via Autophagic Cell Death
by: Nang Lae Lae Phoo, et al.
Published: (2021-11-01)

A graphical, interactive and GPU-enabled workflow to process long-read sequencing data
by: Shishir Reddy, et al.
Published: (2021-08-01)

Sero-epidemiological Study of Toxoplasma gondii among Pregnant Women in Akre City
by: Hogir Mohammed Shukri Saadi, et al.
Published: (2020-12-01)

AKR1C3 in carcinomas: from multifaceted roles to therapeutic strategies
by: Mengnan Li, et al.
Published: (2024-03-01)

AKR1C3 Is Associated with Better Survival of Patients with Endometrial Carcinomas
by: Marko Hojnik, et al.
Published: (2020-12-01)

ECMI resonance in AKR revisited: Hyperbolic resonance, harmonics, and wave–wave interaction
by: W. Baumjohann, et al.
Published: (2023-03-01)

Diagnostic and Prognostic Potential of AKR1B10 in Human Hepatocellular Carcinoma
by: Johanna K. DiStefano, et al.
Published: (2019-04-01)

Mezbaha Atıksuyunun Koagülasyon/Flokülasyon-Ardışık Kesikli Reaktör (AKR) Yöntemiyle Arıtılması
by: Engin Gürteki̇n
Published: (2009-08-01)

Expression of AKR1C3 Protein in Human Keloid Skin Tissue
by: Doo Hyun Nam, et al.
Published: (2016-02-01)

The expression and significance of AKR1B10 in laryngeal squamous cell carcinoma
by: Jixuan Liu, et al.
Published: (2021-09-01)

Neutron noise experiments in the AKR-2 and CROCUS reactors for the European project CORTEX
by: Lamirand Vincent, et al.
Published: (2020-01-01)

Observational study of generation conditions of substorm-associated low-frequency AKR emissions
by: A. Olsson, et al.
Published: (2004-11-01)

Rapid detection of myeloid neoplasm fusions using single-molecule long-read sequencing.
by: Olga Sala-Torra, et al.
Published: (2023-01-01)

Long read sequencing characterises a novel structural variant, revealing underactive AKR1C1 with overactive AKR1C2 as a possible cause of severe chronic fatigue
by: Julia Oakley, et al.
Published: (2023-11-01)

Venetoclax for Children and Adolescents with Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma
by: Amber Gibson, et al.
Published: (2021-12-01)