Comparison of cryptococcal meningitis in HIV-negative patients with and without lung infections
Objective To investigate the clinical features and outcomes of cryptococcal meningitis (CM) in HIV-negative patients with and without lung infections. Methods We retrospectively reviewed the medical records of HIV-negative patients with CM admitted to two university hospitals in Southwest China over...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-06-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/0300060520929591 |
| _version_ | 1818898428692791296 |
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| author | Ming Yang Lin Cheng Fengjun Sun Fu Liu Wei Feng Pu Yao Bangbi Weng Peiyuan Xia |
| author_facet | Ming Yang Lin Cheng Fengjun Sun Fu Liu Wei Feng Pu Yao Bangbi Weng Peiyuan Xia |
| author_sort | Ming Yang |
| collection | DOAJ |
| description | Objective To investigate the clinical features and outcomes of cryptococcal meningitis (CM) in HIV-negative patients with and without lung infections. Methods We retrospectively reviewed the medical records of HIV-negative patients with CM admitted to two university hospitals in Southwest China over the past 5 years. Results Seventy-one patients were included, of whom 35 (49.3%) had lung disease. Compared with patients without lung infection, CM patients with lung infection tended to be male and younger (≤30 years), experienced more fever, less vomiting and fewer central nervous system symptoms; more often had low white blood cell (WBC) counts (<20 × 10 6 /L), and fewer often had ethmoid sinusitis, maxillary sinusitis, paranasal sinusitis, and otitis media. Cryptococcus neoformans isolates from these patients were sensitive to itraconazole, voriconazole, fluconazole, and amphotericin B but resistant to flucytosine. CM patients with lung infection had higher mortality at discharge compared with patients without lung infection (8.6% vs. 0%). Multivariable analyses showed that a WBC count <20 × 10 6 /L was significantly associated with poor treatment outcome (odds ratio 0.01, 95% confidence interval 0–0.83). Conclusion HIV-negative CM patients with lung infections tended to be male and younger. Fever, fewer central nervous system symptoms, and WBC counts <20 × 10 6 /L were characteristic of this patient group. |
| first_indexed | 2024-12-19T19:31:55Z |
| format | Article |
| id | doaj.art-d9f1b32ee59e4cd68d28d08f574a9236 |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-12-19T19:31:55Z |
| publishDate | 2020-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-d9f1b32ee59e4cd68d28d08f574a92362022-12-21T20:08:34ZengSAGE PublishingJournal of International Medical Research1473-23002020-06-014810.1177/0300060520929591Comparison of cryptococcal meningitis in HIV-negative patients with and without lung infectionsMing YangLin ChengFengjun SunFu LiuWei FengPu YaoBangbi WengPeiyuan XiaObjective To investigate the clinical features and outcomes of cryptococcal meningitis (CM) in HIV-negative patients with and without lung infections. Methods We retrospectively reviewed the medical records of HIV-negative patients with CM admitted to two university hospitals in Southwest China over the past 5 years. Results Seventy-one patients were included, of whom 35 (49.3%) had lung disease. Compared with patients without lung infection, CM patients with lung infection tended to be male and younger (≤30 years), experienced more fever, less vomiting and fewer central nervous system symptoms; more often had low white blood cell (WBC) counts (<20 × 10 6 /L), and fewer often had ethmoid sinusitis, maxillary sinusitis, paranasal sinusitis, and otitis media. Cryptococcus neoformans isolates from these patients were sensitive to itraconazole, voriconazole, fluconazole, and amphotericin B but resistant to flucytosine. CM patients with lung infection had higher mortality at discharge compared with patients without lung infection (8.6% vs. 0%). Multivariable analyses showed that a WBC count <20 × 10 6 /L was significantly associated with poor treatment outcome (odds ratio 0.01, 95% confidence interval 0–0.83). Conclusion HIV-negative CM patients with lung infections tended to be male and younger. Fever, fewer central nervous system symptoms, and WBC counts <20 × 10 6 /L were characteristic of this patient group.https://doi.org/10.1177/0300060520929591 |
| spellingShingle | Ming Yang Lin Cheng Fengjun Sun Fu Liu Wei Feng Pu Yao Bangbi Weng Peiyuan Xia Comparison of cryptococcal meningitis in HIV-negative patients with and without lung infections Journal of International Medical Research |
| title | Comparison of cryptococcal meningitis in HIV-negative patients with and without lung infections |
| title_full | Comparison of cryptococcal meningitis in HIV-negative patients with and without lung infections |
| title_fullStr | Comparison of cryptococcal meningitis in HIV-negative patients with and without lung infections |
| title_full_unstemmed | Comparison of cryptococcal meningitis in HIV-negative patients with and without lung infections |
| title_short | Comparison of cryptococcal meningitis in HIV-negative patients with and without lung infections |
| title_sort | comparison of cryptococcal meningitis in hiv negative patients with and without lung infections |
| url | https://doi.org/10.1177/0300060520929591 |
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