Research progress on the relationship between ACE2 ⁃ Ang ⁃ (1 ⁃ 7) ⁃ MasR axis and central nervous system diseases
Renin⁃angiotensin system (RAS) plays an important role in maintaining cardiovascular homeostasis, water and electrolyte balance in the body, and angiotensin converting enzyme Ⅱ (ACE2) and its axis of action angiotensin⁃(1⁃7) [Ang⁃(1⁃7)] and Mas receptor (MasR) composed of Ang⁃(1⁃7) and MasR axis can...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Tianjin Huanhu Hospital
2022-08-01
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| Series: | Chinese Journal of Contemporary Neurology and Neurosurgery |
| Subjects: | |
| Online Access: | http://www.cjcnn.org/index.php/cjcnn/article/view/2555 |
| _version_ | 1828735097037127680 |
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| author | LIANG He LIN Jian⁃wen MO Ming XIE Lu⁃shuang DU Shi⁃wei LIU Yi |
| author_facet | LIANG He LIN Jian⁃wen MO Ming XIE Lu⁃shuang DU Shi⁃wei LIU Yi |
| author_sort | LIANG He |
| collection | DOAJ |
| description | Renin⁃angiotensin system (RAS) plays an important role in maintaining cardiovascular homeostasis, water and electrolyte balance in the body, and angiotensin converting enzyme Ⅱ (ACE2) and its axis of action angiotensin⁃(1⁃7) [Ang⁃(1⁃7)] and Mas receptor (MasR) composed of Ang⁃(1⁃7) and MasR axis can play an important role in this process, it can widely participate in the pathophysiological process of central nervous system diseases. Based on the structure and function of RAS, this study plans to sort out the latest relevant research results on the role of ACE2⁃Ang⁃(1⁃7)⁃MasR axis in ischemic stroke, cognitive dysfunction, anxiety state and neurodegenerative disease, improve the understanding of researchers and clinicians, and provide ideas for the development of new targets for central nervous system disease drugs in the future. |
| first_indexed | 2024-04-12T23:00:38Z |
| format | Article |
| id | doaj.art-d9f21d83bf4b4b9f90e9d5c92c28196b |
| institution | Directory Open Access Journal |
| issn | 1672-6731 |
| language | English |
| last_indexed | 2024-04-12T23:00:38Z |
| publishDate | 2022-08-01 |
| publisher | Tianjin Huanhu Hospital |
| record_format | Article |
| series | Chinese Journal of Contemporary Neurology and Neurosurgery |
| spelling | doaj.art-d9f21d83bf4b4b9f90e9d5c92c28196b2022-12-22T03:13:04ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312022-08-01220873874110.3969/j.issn.1672⁃6731.2022.08.014Research progress on the relationship between ACE2 ⁃ Ang ⁃ (1 ⁃ 7) ⁃ MasR axis and central nervous system diseasesLIANG He 0LIN Jian⁃wen 1MO Ming2 XIE Lu⁃shuang 3DU Shi⁃wei 4 LIU Yi 5 Department of Neurology, Dalian Municipal Central HospitalDepartment of Neurology, Dalian Municipal Central HospitalDepartment of Neurology, Dalian Municipal Central Hospital School of Basic Medicine, Chengdu University of Traditional Chinese MedicineDepartment of Neurosurgery, South China Hospital of Shenzhen University Department of Neurology, Dalian Municipal Central HospitalRenin⁃angiotensin system (RAS) plays an important role in maintaining cardiovascular homeostasis, water and electrolyte balance in the body, and angiotensin converting enzyme Ⅱ (ACE2) and its axis of action angiotensin⁃(1⁃7) [Ang⁃(1⁃7)] and Mas receptor (MasR) composed of Ang⁃(1⁃7) and MasR axis can play an important role in this process, it can widely participate in the pathophysiological process of central nervous system diseases. Based on the structure and function of RAS, this study plans to sort out the latest relevant research results on the role of ACE2⁃Ang⁃(1⁃7)⁃MasR axis in ischemic stroke, cognitive dysfunction, anxiety state and neurodegenerative disease, improve the understanding of researchers and clinicians, and provide ideas for the development of new targets for central nervous system disease drugs in the future.http://www.cjcnn.org/index.php/cjcnn/article/view/2555central nervous system diseasesrenin⁃angiotensin systempeptidyl⁃dipeptidase areview |
| spellingShingle | LIANG He LIN Jian⁃wen MO Ming XIE Lu⁃shuang DU Shi⁃wei LIU Yi Research progress on the relationship between ACE2 ⁃ Ang ⁃ (1 ⁃ 7) ⁃ MasR axis and central nervous system diseases Chinese Journal of Contemporary Neurology and Neurosurgery central nervous system diseases renin⁃angiotensin system peptidyl⁃dipeptidase a review |
| title | Research progress on the relationship between ACE2 ⁃ Ang ⁃ (1 ⁃ 7) ⁃ MasR axis and central nervous system diseases |
| title_full | Research progress on the relationship between ACE2 ⁃ Ang ⁃ (1 ⁃ 7) ⁃ MasR axis and central nervous system diseases |
| title_fullStr | Research progress on the relationship between ACE2 ⁃ Ang ⁃ (1 ⁃ 7) ⁃ MasR axis and central nervous system diseases |
| title_full_unstemmed | Research progress on the relationship between ACE2 ⁃ Ang ⁃ (1 ⁃ 7) ⁃ MasR axis and central nervous system diseases |
| title_short | Research progress on the relationship between ACE2 ⁃ Ang ⁃ (1 ⁃ 7) ⁃ MasR axis and central nervous system diseases |
| title_sort | research progress on the relationship between ace2 ⁃ ang ⁃ 1 ⁃ 7 ⁃ masr axis and central nervous system diseases |
| topic | central nervous system diseases renin⁃angiotensin system peptidyl⁃dipeptidase a review |
| url | http://www.cjcnn.org/index.php/cjcnn/article/view/2555 |
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