Hypertension and endothelial dysfunction in the pristane model of systemic lupus erythematosus
Abstract Autoimmune diseases such as psoriasis, rheumatoid arthritis, and systemic lupus erythematosus (SLE) have high rates of hypertension and cardiovascular disease. Systemic lupus erythematosus is a prototypic autoimmune disorder that primarily affects women of childbearing age and is associated...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-02-01
|
| Series: | Physiological Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.14814/phy2.14734 |
| _version_ | 1818461596166389760 |
|---|---|
| author | Daniel M. McClung William J. Kalusche Katie E. Jones Michael J. Ryan Erin B. Taylor |
| author_facet | Daniel M. McClung William J. Kalusche Katie E. Jones Michael J. Ryan Erin B. Taylor |
| author_sort | Daniel M. McClung |
| collection | DOAJ |
| description | Abstract Autoimmune diseases such as psoriasis, rheumatoid arthritis, and systemic lupus erythematosus (SLE) have high rates of hypertension and cardiovascular disease. Systemic lupus erythematosus is a prototypic autoimmune disorder that primarily affects women of childbearing age and is associated with a loss of self‐tolerance, autoreactive B and T lymphocytes, and the production of autoantibodies, especially to nuclear components. In this study, we hypothesized that the pristane‐inducible model of SLE would develop hypertension and vascular dysfunction as the disease progressed. To test this hypothesis, female C57BL/6 mice were administered PBS or pristane. Seven months after pristane administration, mice developed various autoantibodies, including anti‐dsDNA IgG, anti‐ssDNA IgG, and anti‐nRNP IgG, as well as hypergammaglobulinemia. Several other immunological changes, including increased circulating neutrophils and increased CD4−CD8− (double negative) thymocytes were also detected. Mean arterial pressure (MAP) was elevated in pristane‐treated mice when compared to PBS‐treated mice. In addition, second‐order mesenteric arteries from pristine‐treated mice had impaired relaxation to the endothelium‐dependent vasodilator acetylcholine compared to PBS‐treated mice. These data suggest that the immune system dysfunction present in the pristane model of lupus contributes to the development of hypertension and vascular dysfunction. |
| first_indexed | 2024-12-14T23:48:39Z |
| format | Article |
| id | doaj.art-d9f24eeca8644853a679bb6aff943dd3 |
| institution | Directory Open Access Journal |
| issn | 2051-817X |
| language | English |
| last_indexed | 2024-12-14T23:48:39Z |
| publishDate | 2021-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj.art-d9f24eeca8644853a679bb6aff943dd32022-12-21T22:43:19ZengWileyPhysiological Reports2051-817X2021-02-0193n/an/a10.14814/phy2.14734Hypertension and endothelial dysfunction in the pristane model of systemic lupus erythematosusDaniel M. McClung0William J. Kalusche1Katie E. Jones2Michael J. Ryan3Erin B. Taylor4Department of Physiology and Biophysics University of Mississippi Medical Center Jackson MS USADepartment of Physiology and Biophysics University of Mississippi Medical Center Jackson MS USADepartment of Physiology and Biophysics University of Mississippi Medical Center Jackson MS USADepartment of Physiology and Biophysics University of Mississippi Medical Center Jackson MS USADepartment of Physiology and Biophysics University of Mississippi Medical Center Jackson MS USAAbstract Autoimmune diseases such as psoriasis, rheumatoid arthritis, and systemic lupus erythematosus (SLE) have high rates of hypertension and cardiovascular disease. Systemic lupus erythematosus is a prototypic autoimmune disorder that primarily affects women of childbearing age and is associated with a loss of self‐tolerance, autoreactive B and T lymphocytes, and the production of autoantibodies, especially to nuclear components. In this study, we hypothesized that the pristane‐inducible model of SLE would develop hypertension and vascular dysfunction as the disease progressed. To test this hypothesis, female C57BL/6 mice were administered PBS or pristane. Seven months after pristane administration, mice developed various autoantibodies, including anti‐dsDNA IgG, anti‐ssDNA IgG, and anti‐nRNP IgG, as well as hypergammaglobulinemia. Several other immunological changes, including increased circulating neutrophils and increased CD4−CD8− (double negative) thymocytes were also detected. Mean arterial pressure (MAP) was elevated in pristane‐treated mice when compared to PBS‐treated mice. In addition, second‐order mesenteric arteries from pristine‐treated mice had impaired relaxation to the endothelium‐dependent vasodilator acetylcholine compared to PBS‐treated mice. These data suggest that the immune system dysfunction present in the pristane model of lupus contributes to the development of hypertension and vascular dysfunction.https://doi.org/10.14814/phy2.14734autoantibodiesautoimmunityendothelial dysfunctionhypertensionpristanesystemic lupus erythematosus |
| spellingShingle | Daniel M. McClung William J. Kalusche Katie E. Jones Michael J. Ryan Erin B. Taylor Hypertension and endothelial dysfunction in the pristane model of systemic lupus erythematosus Physiological Reports autoantibodies autoimmunity endothelial dysfunction hypertension pristane systemic lupus erythematosus |
| title | Hypertension and endothelial dysfunction in the pristane model of systemic lupus erythematosus |
| title_full | Hypertension and endothelial dysfunction in the pristane model of systemic lupus erythematosus |
| title_fullStr | Hypertension and endothelial dysfunction in the pristane model of systemic lupus erythematosus |
| title_full_unstemmed | Hypertension and endothelial dysfunction in the pristane model of systemic lupus erythematosus |
| title_short | Hypertension and endothelial dysfunction in the pristane model of systemic lupus erythematosus |
| title_sort | hypertension and endothelial dysfunction in the pristane model of systemic lupus erythematosus |
| topic | autoantibodies autoimmunity endothelial dysfunction hypertension pristane systemic lupus erythematosus |
| url | https://doi.org/10.14814/phy2.14734 |
| work_keys_str_mv | AT danielmmcclung hypertensionandendothelialdysfunctioninthepristanemodelofsystemiclupuserythematosus AT williamjkalusche hypertensionandendothelialdysfunctioninthepristanemodelofsystemiclupuserythematosus AT katieejones hypertensionandendothelialdysfunctioninthepristanemodelofsystemiclupuserythematosus AT michaeljryan hypertensionandendothelialdysfunctioninthepristanemodelofsystemiclupuserythematosus AT erinbtaylor hypertensionandendothelialdysfunctioninthepristanemodelofsystemiclupuserythematosus |