β-conglycinin combined with fenofibrate or rosuvastatin have exerted distinct hypocholesterolemic effects in rats
<p>Abstract</p> <p>Background</p> <p>There is increasing interest in non-pharmacological control of cholesterol and triglyceride levels in the plasma and diet-drug association represent an important area of studies. The objective of this study was to observe the hypocho...
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| Format: | Article |
| Language: | English |
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BMC
2012-01-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | http://www.lipidworld.com/content/11/1/11 |
| _version_ | 1819045015896195072 |
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| author | Ferreira Ederlan S Silva Maraiza A Demonte Aureluce Neves Valdir A |
| author_facet | Ferreira Ederlan S Silva Maraiza A Demonte Aureluce Neves Valdir A |
| author_sort | Ferreira Ederlan S |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>There is increasing interest in non-pharmacological control of cholesterol and triglyceride levels in the plasma and diet-drug association represent an important area of studies. The objective of this study was to observe the hypocholesterolemic effect of soybean β-conglycinin (7S protein) alone and combined with fenofibrate and rosuvastatin, two hypolipidemic drugs.</p> <p>Methods</p> <p>The protein and drugs were administered orally once a day to rats and the effects were evaluated after 28 days. Wistar rats were divided into six groups (n = 9): hypercholesterolemic diet (HC), HC+7S protein (300 mg.kg-1 day-1) (HC-7S), HC+fenofibrate (30 mg.kg-1 day-1)(HC-FF), HC+rosuvastatin (10 mg.kg-1 day-1)(HC-RO), HC+7S+fenofibrate (HC-7S-FF) and HC+7S+rosuvastatin (HC-7S-RO).</p> <p>Results</p> <p>Animals in HC-7S, HC-FF and HC-RO exhibited reductions of 22.9, 35.8 and 18.8% in total plasma cholesterol, respectively. In HC-7S-FF, animals did not show significant alteration of the level in HC+FF while the group HC-7S-RO showed a negative effect in comparison with groups taking only protein (HC-7S) or drug (HC-RO). The administration of the protein, fenofibrate and rosuvastatin alone caused increases in the plasma HDL-C of the animals, while the protein-drug combinations led to an increase compared to HC-FF and HC-RO. The plasma concentration of triacylgycerides was significantly reduced in the groups without association, while HC-7S-FF showed no alteration and HC-7S-RO a little reduction.</p> <p>Conclusion</p> <p>The results of our study indicate that conglycinin has effects comparable to fenofibrate and rosuvastatin on the control of plasma cholesterol, HDL-C and triacylglycerides, when given to hypercholesterolemic rats, and suggests that the association of this protein with rosuvastatin alters the action of drug in the homeostasis of cholesterol.</p> |
| first_indexed | 2024-12-21T10:21:52Z |
| format | Article |
| id | doaj.art-d9f2d68cdb7c4f628d0ecc7fe63b801a |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-21T10:21:52Z |
| publishDate | 2012-01-01 |
| publisher | BMC |
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| series | Lipids in Health and Disease |
| spelling | doaj.art-d9f2d68cdb7c4f628d0ecc7fe63b801a2022-12-21T19:07:25ZengBMCLipids in Health and Disease1476-511X2012-01-011111110.1186/1476-511X-11-11β-conglycinin combined with fenofibrate or rosuvastatin have exerted distinct hypocholesterolemic effects in ratsFerreira Ederlan SSilva Maraiza ADemonte AureluceNeves Valdir A<p>Abstract</p> <p>Background</p> <p>There is increasing interest in non-pharmacological control of cholesterol and triglyceride levels in the plasma and diet-drug association represent an important area of studies. The objective of this study was to observe the hypocholesterolemic effect of soybean β-conglycinin (7S protein) alone and combined with fenofibrate and rosuvastatin, two hypolipidemic drugs.</p> <p>Methods</p> <p>The protein and drugs were administered orally once a day to rats and the effects were evaluated after 28 days. Wistar rats were divided into six groups (n = 9): hypercholesterolemic diet (HC), HC+7S protein (300 mg.kg-1 day-1) (HC-7S), HC+fenofibrate (30 mg.kg-1 day-1)(HC-FF), HC+rosuvastatin (10 mg.kg-1 day-1)(HC-RO), HC+7S+fenofibrate (HC-7S-FF) and HC+7S+rosuvastatin (HC-7S-RO).</p> <p>Results</p> <p>Animals in HC-7S, HC-FF and HC-RO exhibited reductions of 22.9, 35.8 and 18.8% in total plasma cholesterol, respectively. In HC-7S-FF, animals did not show significant alteration of the level in HC+FF while the group HC-7S-RO showed a negative effect in comparison with groups taking only protein (HC-7S) or drug (HC-RO). The administration of the protein, fenofibrate and rosuvastatin alone caused increases in the plasma HDL-C of the animals, while the protein-drug combinations led to an increase compared to HC-FF and HC-RO. The plasma concentration of triacylgycerides was significantly reduced in the groups without association, while HC-7S-FF showed no alteration and HC-7S-RO a little reduction.</p> <p>Conclusion</p> <p>The results of our study indicate that conglycinin has effects comparable to fenofibrate and rosuvastatin on the control of plasma cholesterol, HDL-C and triacylglycerides, when given to hypercholesterolemic rats, and suggests that the association of this protein with rosuvastatin alters the action of drug in the homeostasis of cholesterol.</p>http://www.lipidworld.com/content/11/1/11β-conglycinincholesterol-lowering drugshypercholesterolemic dietrats. |
| spellingShingle | Ferreira Ederlan S Silva Maraiza A Demonte Aureluce Neves Valdir A β-conglycinin combined with fenofibrate or rosuvastatin have exerted distinct hypocholesterolemic effects in rats Lipids in Health and Disease β-conglycinin cholesterol-lowering drugs hypercholesterolemic diet rats. |
| title | β-conglycinin combined with fenofibrate or rosuvastatin have exerted distinct hypocholesterolemic effects in rats |
| title_full | β-conglycinin combined with fenofibrate or rosuvastatin have exerted distinct hypocholesterolemic effects in rats |
| title_fullStr | β-conglycinin combined with fenofibrate or rosuvastatin have exerted distinct hypocholesterolemic effects in rats |
| title_full_unstemmed | β-conglycinin combined with fenofibrate or rosuvastatin have exerted distinct hypocholesterolemic effects in rats |
| title_short | β-conglycinin combined with fenofibrate or rosuvastatin have exerted distinct hypocholesterolemic effects in rats |
| title_sort | β conglycinin combined with fenofibrate or rosuvastatin have exerted distinct hypocholesterolemic effects in rats |
| topic | β-conglycinin cholesterol-lowering drugs hypercholesterolemic diet rats. |
| url | http://www.lipidworld.com/content/11/1/11 |
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