Production of hybrid-IgG/IgA plantibodies with neutralizing activity against Shiga toxin 1.

Production of hybrid-IgG/IgA plantibodies with neutralizing activity against Shiga toxin 1.

Shiga toxin 1 (Stx1) is a virulence factor of enterohemorrhagic Escherichia coli, such as the O157:H7 strain. In the intestines, secretory IgA (SIgA) is a major component of the immune defense against pathogens and toxins. To form SIgA, the production of dimeric IgA that retains biological activity...

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Bibliographic Details
Main Authors: Katsuhiro Nakanishi, Sanshiro Narimatsu, Shiori Ichikawa, Yuki Tobisawa, Kohta Kurohane, Yasuo Niwa, Hirokazu Kobayashi, Yasuyuki Imai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3842918?pdf=render

Internet

http://europepmc.org/articles/PMC3842918?pdf=render

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