Mapping optogenetically-driven single-vessel fMRI with concurrent neuronal calcium recordings in the rat hippocampus
Detailed characterization of large-scale hemodynamic responses linked to specific neural activity remains to be elucidated at the single-vessel level across the subcentimeter scale hippocampal vasculature in vivo. Here, authors use a novel multi-modal fMRI platform to characterize distinct spatiotem...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-12850-x |
| _version_ | 1818842085931876352 |
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| author | Xuming Chen Filip Sobczak Yi Chen Yuanyuan Jiang Chunqi Qian Zuneng Lu Cenk Ayata Nikos K. Logothetis Xin Yu |
| author_facet | Xuming Chen Filip Sobczak Yi Chen Yuanyuan Jiang Chunqi Qian Zuneng Lu Cenk Ayata Nikos K. Logothetis Xin Yu |
| author_sort | Xuming Chen |
| collection | DOAJ |
| description | Detailed characterization of large-scale hemodynamic responses linked to specific neural activity remains to be elucidated at the single-vessel level across the subcentimeter scale hippocampal vasculature in vivo. Here, authors use a novel multi-modal fMRI platform to characterize distinct spatiotemporal patterns of hippocampal hemodynamic responses that were correlated to the optogenetically evoked Ca2+ events and to further demonstrate the significantly reduced neurovascular coupling efficiency upon spreading depression-like Ca2+ events. |
| first_indexed | 2024-12-19T04:36:22Z |
| format | Article |
| id | doaj.art-d9f4bff0de2c4e8aaf801a87e8442fb5 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T04:36:22Z |
| publishDate | 2019-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d9f4bff0de2c4e8aaf801a87e8442fb52022-12-21T20:35:44ZengNature PortfolioNature Communications2041-17232019-11-0110111210.1038/s41467-019-12850-xMapping optogenetically-driven single-vessel fMRI with concurrent neuronal calcium recordings in the rat hippocampusXuming Chen0Filip Sobczak1Yi Chen2Yuanyuan Jiang3Chunqi Qian4Zuneng Lu5Cenk Ayata6Nikos K. Logothetis7Xin Yu8Research Group of Translational Neuroimaging and Neural Control, High-Field Magnetic Resonance, Max Planck Institute for Biological CyberneticsResearch Group of Translational Neuroimaging and Neural Control, High-Field Magnetic Resonance, Max Planck Institute for Biological CyberneticsResearch Group of Translational Neuroimaging and Neural Control, High-Field Magnetic Resonance, Max Planck Institute for Biological CyberneticsResearch Group of Translational Neuroimaging and Neural Control, High-Field Magnetic Resonance, Max Planck Institute for Biological CyberneticsDepartment of Radiology, Michigan State UniversityDepartment of Neurology, Wuhan University, Renmin HospitalNeurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Physiology of Cognitive Processes, Max Planck Institute for Biological CyberneticsResearch Group of Translational Neuroimaging and Neural Control, High-Field Magnetic Resonance, Max Planck Institute for Biological CyberneticsDetailed characterization of large-scale hemodynamic responses linked to specific neural activity remains to be elucidated at the single-vessel level across the subcentimeter scale hippocampal vasculature in vivo. Here, authors use a novel multi-modal fMRI platform to characterize distinct spatiotemporal patterns of hippocampal hemodynamic responses that were correlated to the optogenetically evoked Ca2+ events and to further demonstrate the significantly reduced neurovascular coupling efficiency upon spreading depression-like Ca2+ events.https://doi.org/10.1038/s41467-019-12850-x |
| spellingShingle | Xuming Chen Filip Sobczak Yi Chen Yuanyuan Jiang Chunqi Qian Zuneng Lu Cenk Ayata Nikos K. Logothetis Xin Yu Mapping optogenetically-driven single-vessel fMRI with concurrent neuronal calcium recordings in the rat hippocampus Nature Communications |
| title | Mapping optogenetically-driven single-vessel fMRI with concurrent neuronal calcium recordings in the rat hippocampus |
| title_full | Mapping optogenetically-driven single-vessel fMRI with concurrent neuronal calcium recordings in the rat hippocampus |
| title_fullStr | Mapping optogenetically-driven single-vessel fMRI with concurrent neuronal calcium recordings in the rat hippocampus |
| title_full_unstemmed | Mapping optogenetically-driven single-vessel fMRI with concurrent neuronal calcium recordings in the rat hippocampus |
| title_short | Mapping optogenetically-driven single-vessel fMRI with concurrent neuronal calcium recordings in the rat hippocampus |
| title_sort | mapping optogenetically driven single vessel fmri with concurrent neuronal calcium recordings in the rat hippocampus |
| url | https://doi.org/10.1038/s41467-019-12850-x |
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