Structural characterization of human cholesterol 7α-hydroxylase

Structural characterization of human cholesterol 7α-hydroxylase

Hepatic conversion to bile acids is a major elimination route for cholesterol in mammals. CYP7A1 catalyzes the first and rate-limiting step in classic bile acid biosynthesis, converting cholesterol to 7α-hydroxycholesterol. To identify the structural determinants that govern the stereospecific hydro...

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Bibliographic Details
Main Authors: Wolfram Tempel, Irina Grabovec, Farrell MacKenzie, Yaroslav V. Dichenko, Sergey A. Usanov, Andrei A. Gilep, Hee-Won Park, Natallia Strushkevich
Format: Article
Language:English
Published: Elsevier 2014-09-01
Series:Journal of Lipid Research
Subjects:
cytochrome P450
X-ray crystallography CYP7A1
oxysterols
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520356686

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