A Population-Based Cross-Sectional Study of Paediatric Coeliac Disease in Catalonia Showed a Downward Trend in Prevalence Compared to the Previous Decade
(1) Background: Previous studies showed an increased prevalence and incidence of coeliac disease (CD) over time. The objective is to ascertain whether the CD prevalence in Catalonia (a region of Southern Europe) among children aged 1–5 is as high as previously found in 2004–2009; (2) Methods: From 2...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/24/5100 |
| _version_ | 1797379811088269312 |
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| author | Beatriz Arau Beatriz Dietl Emma Sudrià-Lopez Josefa Ribes Laura Pareja Teresa Marquès Roger Garcia-Puig Francisco Pujalte Albert Martin-Cardona Fernando Fernández-Bañares Meritxell Mariné Carme Farré Maria Esteve |
| author_facet | Beatriz Arau Beatriz Dietl Emma Sudrià-Lopez Josefa Ribes Laura Pareja Teresa Marquès Roger Garcia-Puig Francisco Pujalte Albert Martin-Cardona Fernando Fernández-Bañares Meritxell Mariné Carme Farré Maria Esteve |
| author_sort | Beatriz Arau |
| collection | DOAJ |
| description | (1) Background: Previous studies showed an increased prevalence and incidence of coeliac disease (CD) over time. The objective is to ascertain whether the CD prevalence in Catalonia (a region of Southern Europe) among children aged 1–5 is as high as previously found in 2004–2009; (2) Methods: From 2013 to 2019, 3659 subjects aged 1–5 years were recruited following the previously used methodology. Factors with a potential impact on CD prevalence were investigated; (3) Results: In 2013–2019, 43/3659 subjects had positive serology, giving a standardised seroprevalence of 12.55/1000 (95% CI: 8.92; 17.40), compared to 23.62 (13.21; 39.40) in 2004–2007. The biopsy-proven crude prevalence was 7.92/1000 (95% CI: 5.50; 11.30), and the crude prevalence based on ESPGHAN criteria was 8.74/1000 (95% CI: 6.20–12.30). In contrast to 2004–2009, we did not find differences in the seroprevalence rates between 1 and 2 years vs. 3 and 4 years of age (age percentage of change −7.0 (−29.5; 22.8) vs. −45.3 (−67.5; −8.0)). Rotavirus vaccination was the most remarkable potential protective factor (48% vs. 9% in 2004–2009; <i>p</i> < 0.0001), but not the time of gluten introduction. (4) Conclusion: The present study did not confirm a worldwide CD prevalence increase and emphasizes the need to perform prevalence studies over time using the same methodology in the same geographical areas. |
| first_indexed | 2024-03-08T20:28:25Z |
| format | Article |
| id | doaj.art-d9f5184d633a4f128cb6678fb58b3ee0 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-08T20:28:25Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-d9f5184d633a4f128cb6678fb58b3ee02023-12-22T14:30:10ZengMDPI AGNutrients2072-66432023-12-011524510010.3390/nu15245100A Population-Based Cross-Sectional Study of Paediatric Coeliac Disease in Catalonia Showed a Downward Trend in Prevalence Compared to the Previous DecadeBeatriz Arau0Beatriz Dietl1Emma Sudrià-Lopez2Josefa Ribes3Laura Pareja4Teresa Marquès5Roger Garcia-Puig6Francisco Pujalte7Albert Martin-Cardona8Fernando Fernández-Bañares9Meritxell Mariné10Carme Farré11Maria Esteve12Digestive Diseases Department, Hospital Universitari Mútua Terrassa, Universitat de Barcelona, Pl. del Doctor Robert 5, 08221 Terrassa, SpainInternal Medicine and Infectious Diseases Department, Hospital Universitari Mútua Terrassa, Universitat de Barcelona, Pl. del Doctor Robert 5, 08221 Terrassa, SpainDigestive Diseases Department, Hospital Universitari Mútua Terrassa, Universitat de Barcelona, Pl. del Doctor Robert 5, 08221 Terrassa, SpainICO-ICS Multicenter Hospital Tumor Registry Service, Catalan Institute of Oncology, Gran via de l’Hospitalet 199-203, 08908 L’Hospitalet de Llobregat, SpainICO-ICS Multicenter Hospital Tumor Registry Service, Catalan Institute of Oncology, Gran via de l’Hospitalet 199-203, 08908 L’Hospitalet de Llobregat, SpainDepartment of Biochemistry, Hospital de Sant Joan de Déu, Passeig Sant Joan de Déu 2, 08950 Esplugues de Llobregat, SpainDepartment of Paediatrics, Hospital Universitari Mútua Terrassa, Universitat de Barcelona, Pl. del Doctor Robert 5, 08221 Terrassa, SpainCatlab, Department of Immunology, Vial St Jordi s/n, 08232 Viladecavalls, SpainDigestive Diseases Department, Hospital Universitari Mútua Terrassa, Universitat de Barcelona, Pl. del Doctor Robert 5, 08221 Terrassa, SpainDigestive Diseases Department, Hospital Universitari Mútua Terrassa, Universitat de Barcelona, Pl. del Doctor Robert 5, 08221 Terrassa, SpainCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Av. Monforte de Lemos 3-5, Pabellón 11, 28029 Madrid, SpainDepartment of Biochemistry, Hospital de Sant Joan de Déu, Passeig Sant Joan de Déu 2, 08950 Esplugues de Llobregat, SpainDigestive Diseases Department, Hospital Universitari Mútua Terrassa, Universitat de Barcelona, Pl. del Doctor Robert 5, 08221 Terrassa, Spain(1) Background: Previous studies showed an increased prevalence and incidence of coeliac disease (CD) over time. The objective is to ascertain whether the CD prevalence in Catalonia (a region of Southern Europe) among children aged 1–5 is as high as previously found in 2004–2009; (2) Methods: From 2013 to 2019, 3659 subjects aged 1–5 years were recruited following the previously used methodology. Factors with a potential impact on CD prevalence were investigated; (3) Results: In 2013–2019, 43/3659 subjects had positive serology, giving a standardised seroprevalence of 12.55/1000 (95% CI: 8.92; 17.40), compared to 23.62 (13.21; 39.40) in 2004–2007. The biopsy-proven crude prevalence was 7.92/1000 (95% CI: 5.50; 11.30), and the crude prevalence based on ESPGHAN criteria was 8.74/1000 (95% CI: 6.20–12.30). In contrast to 2004–2009, we did not find differences in the seroprevalence rates between 1 and 2 years vs. 3 and 4 years of age (age percentage of change −7.0 (−29.5; 22.8) vs. −45.3 (−67.5; −8.0)). Rotavirus vaccination was the most remarkable potential protective factor (48% vs. 9% in 2004–2009; <i>p</i> < 0.0001), but not the time of gluten introduction. (4) Conclusion: The present study did not confirm a worldwide CD prevalence increase and emphasizes the need to perform prevalence studies over time using the same methodology in the same geographical areas.https://www.mdpi.com/2072-6643/15/24/5100coeliac disease (CD)prevalenceepidemiologygluten introductionrotavirus vaccinebreast feeding |
| spellingShingle | Beatriz Arau Beatriz Dietl Emma Sudrià-Lopez Josefa Ribes Laura Pareja Teresa Marquès Roger Garcia-Puig Francisco Pujalte Albert Martin-Cardona Fernando Fernández-Bañares Meritxell Mariné Carme Farré Maria Esteve A Population-Based Cross-Sectional Study of Paediatric Coeliac Disease in Catalonia Showed a Downward Trend in Prevalence Compared to the Previous Decade Nutrients coeliac disease (CD) prevalence epidemiology gluten introduction rotavirus vaccine breast feeding |
| title | A Population-Based Cross-Sectional Study of Paediatric Coeliac Disease in Catalonia Showed a Downward Trend in Prevalence Compared to the Previous Decade |
| title_full | A Population-Based Cross-Sectional Study of Paediatric Coeliac Disease in Catalonia Showed a Downward Trend in Prevalence Compared to the Previous Decade |
| title_fullStr | A Population-Based Cross-Sectional Study of Paediatric Coeliac Disease in Catalonia Showed a Downward Trend in Prevalence Compared to the Previous Decade |
| title_full_unstemmed | A Population-Based Cross-Sectional Study of Paediatric Coeliac Disease in Catalonia Showed a Downward Trend in Prevalence Compared to the Previous Decade |
| title_short | A Population-Based Cross-Sectional Study of Paediatric Coeliac Disease in Catalonia Showed a Downward Trend in Prevalence Compared to the Previous Decade |
| title_sort | population based cross sectional study of paediatric coeliac disease in catalonia showed a downward trend in prevalence compared to the previous decade |
| topic | coeliac disease (CD) prevalence epidemiology gluten introduction rotavirus vaccine breast feeding |
| url | https://www.mdpi.com/2072-6643/15/24/5100 |
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