Isotretinoin for acne vulgaris – an update on adverse effects and laboratory monitoring
A significant barrier to the usage of isotretinoin has been concerns regarding its adverse effect profile. The dose-dependent mucocutaneous side effects of isotretinoin are well recognized and easily managed, particularly if a lower dose is used. A possible association with depression has gained wid...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2022-07-01
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| Series: | Journal of Dermatological Treatment |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09546634.2021.1967269 |
| _version_ | 1797683502936752128 |
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| author | Haady Fallah Marius Rademaker |
| author_facet | Haady Fallah Marius Rademaker |
| author_sort | Haady Fallah |
| collection | DOAJ |
| description | A significant barrier to the usage of isotretinoin has been concerns regarding its adverse effect profile. The dose-dependent mucocutaneous side effects of isotretinoin are well recognized and easily managed, particularly if a lower dose is used. A possible association with depression has gained widespread media attention and is a source of concern for many patients and their carers, but data from prospective studies and recent meta-analyses have been reassuring. Furthermore, there has been much confusion amongst both patients and physicians regarding a possible association with inflammatory bowel disease, as well the ocular and rheumatological adverse effects of isotretinoin. We provide an update on the evidence surrounding the adverse effects of isotretinoin and discuss practical strategies to prevent and manage these adverse effects. We also discuss appropriate laboratory monitoring for patients taking isotretinoin. |
| first_indexed | 2024-03-12T00:16:23Z |
| format | Article |
| id | doaj.art-d9f5917554e5443494fdacd370f824a0 |
| institution | Directory Open Access Journal |
| issn | 0954-6634 1471-1753 |
| language | English |
| last_indexed | 2024-03-12T00:16:23Z |
| publishDate | 2022-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj.art-d9f5917554e5443494fdacd370f824a02023-09-15T14:28:51ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532022-07-013352414242410.1080/09546634.2021.19672691967269Isotretinoin for acne vulgaris – an update on adverse effects and laboratory monitoringHaady Fallah0Marius Rademaker1Sydney Medical School, Faculty of Medicine and Health, The University of SydneyWaikato Clinical Campus, University of AucklandA significant barrier to the usage of isotretinoin has been concerns regarding its adverse effect profile. The dose-dependent mucocutaneous side effects of isotretinoin are well recognized and easily managed, particularly if a lower dose is used. A possible association with depression has gained widespread media attention and is a source of concern for many patients and their carers, but data from prospective studies and recent meta-analyses have been reassuring. Furthermore, there has been much confusion amongst both patients and physicians regarding a possible association with inflammatory bowel disease, as well the ocular and rheumatological adverse effects of isotretinoin. We provide an update on the evidence surrounding the adverse effects of isotretinoin and discuss practical strategies to prevent and manage these adverse effects. We also discuss appropriate laboratory monitoring for patients taking isotretinoin.http://dx.doi.org/10.1080/09546634.2021.1967269isotretinoinacneretinoidsdepression |
| spellingShingle | Haady Fallah Marius Rademaker Isotretinoin for acne vulgaris – an update on adverse effects and laboratory monitoring Journal of Dermatological Treatment isotretinoin acne retinoids depression |
| title | Isotretinoin for acne vulgaris – an update on adverse effects and laboratory monitoring |
| title_full | Isotretinoin for acne vulgaris – an update on adverse effects and laboratory monitoring |
| title_fullStr | Isotretinoin for acne vulgaris – an update on adverse effects and laboratory monitoring |
| title_full_unstemmed | Isotretinoin for acne vulgaris – an update on adverse effects and laboratory monitoring |
| title_short | Isotretinoin for acne vulgaris – an update on adverse effects and laboratory monitoring |
| title_sort | isotretinoin for acne vulgaris an update on adverse effects and laboratory monitoring |
| topic | isotretinoin acne retinoids depression |
| url | http://dx.doi.org/10.1080/09546634.2021.1967269 |
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