A Novel MDM2-Binding Chalcone Induces Apoptosis of Oral Squamous Cell Carcinoma

A Novel MDM2-Binding Chalcone Induces Apoptosis of Oral Squamous Cell Carcinoma

Oral squamous cell carcinoma (OSCC) represents ~90% of all oral cancers, being the eighth most common cancer in men. The overall 5-year survival rate is only 39% for metastatic cancers, and currently used chemotherapeutics can cause important side effects. Thus, there is an urgency in developing new...

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Bibliographic Details
Main Authors: Guilherme Freimann Wermelinger, Lucas Rubini, Anna Carolina Carvalho da Fonseca, Gabriel Ouverney, Rafael P. R. F. de Oliveira, Acácio S. de Souza, Luana S. M. Forezi, Gabriel Limaverde-Sousa, Sergio Pinheiro, Bruno Kaufmann Robbs
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Biomedicines
Subjects:
chalcone
1,2,3-triazole
MDM2
p53
antitumor
oral squamous cell carcinoma
Online Access:https://www.mdpi.com/2227-9059/11/6/1711

Internet

https://www.mdpi.com/2227-9059/11/6/1711

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