Synaptamide Improves Cognitive Functions and Neuronal Plasticity in Neuropathic Pain
Neuropathic pain arises from damage or dysfunction of the peripheral or central nervous system and manifests itself in a wide variety of sensory symptoms and cognitive disorders. Many studies demonstrate the role of neuropathic pain-induced neuroinflammation in behavioral disorders. For effective ne...
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MDPI AG
2021-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/23/12779 |
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| author | Anna Tyrtyshnaia Anatoly Bondar Sophia Konovalova Igor Manzhulo |
| author_facet | Anna Tyrtyshnaia Anatoly Bondar Sophia Konovalova Igor Manzhulo |
| author_sort | Anna Tyrtyshnaia |
| collection | DOAJ |
| description | Neuropathic pain arises from damage or dysfunction of the peripheral or central nervous system and manifests itself in a wide variety of sensory symptoms and cognitive disorders. Many studies demonstrate the role of neuropathic pain-induced neuroinflammation in behavioral disorders. For effective neuropathic pain treatment, an integrative approach is required, which simultaneously affects several links of pathogenesis. One promising candidate for this role is synaptamide (N-docosahexaenoylethanolamine), which is an endogenous metabolite of docosahexaenoic acid. In this study, we investigated the activity of synaptamide on mice behavior and hippocampal plasticity in neuropathic pain induced by spared nerve injury (SNI). We found a beneficial effect of synaptamide on the thermal allodynia and mechanical hyperalgesia dynamics. Synaptamide prevented working and long-term memory impairment. These results are probably based on the supportive effect of synaptamide on SNI-impaired hippocampal plasticity. Nerve ligation caused microglia activation predominantly in the contralateral hippocampus, while synaptamide inhibited this effect. The treatment reversed dendritic tree degeneration, dendritic spines density reduction on CA1-pyramidal neurons, neurogenesis deterioration, and hippocampal long-term potentiation (LTP) impairment. In addition, synaptamide inhibits changes in the glutamatergic receptor expression. Thus, synaptamide has a beneficial effect on hippocampal functioning, including synaptic plasticity and hippocampus-dependent cognitive processes in neuropathic pain. |
| first_indexed | 2024-03-10T04:53:44Z |
| format | Article |
| id | doaj.art-d9f73f9fb2de45618fe6a33f37f7cce4 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T04:53:44Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d9f73f9fb2de45618fe6a33f37f7cce42023-11-23T02:28:00ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-11-0122231277910.3390/ijms222312779Synaptamide Improves Cognitive Functions and Neuronal Plasticity in Neuropathic PainAnna Tyrtyshnaia0Anatoly Bondar1Sophia Konovalova2Igor Manzhulo3A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, Vladivostok 690041, RussiaA.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, Vladivostok 690041, RussiaA.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, Vladivostok 690041, RussiaA.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, Vladivostok 690041, RussiaNeuropathic pain arises from damage or dysfunction of the peripheral or central nervous system and manifests itself in a wide variety of sensory symptoms and cognitive disorders. Many studies demonstrate the role of neuropathic pain-induced neuroinflammation in behavioral disorders. For effective neuropathic pain treatment, an integrative approach is required, which simultaneously affects several links of pathogenesis. One promising candidate for this role is synaptamide (N-docosahexaenoylethanolamine), which is an endogenous metabolite of docosahexaenoic acid. In this study, we investigated the activity of synaptamide on mice behavior and hippocampal plasticity in neuropathic pain induced by spared nerve injury (SNI). We found a beneficial effect of synaptamide on the thermal allodynia and mechanical hyperalgesia dynamics. Synaptamide prevented working and long-term memory impairment. These results are probably based on the supportive effect of synaptamide on SNI-impaired hippocampal plasticity. Nerve ligation caused microglia activation predominantly in the contralateral hippocampus, while synaptamide inhibited this effect. The treatment reversed dendritic tree degeneration, dendritic spines density reduction on CA1-pyramidal neurons, neurogenesis deterioration, and hippocampal long-term potentiation (LTP) impairment. In addition, synaptamide inhibits changes in the glutamatergic receptor expression. Thus, synaptamide has a beneficial effect on hippocampal functioning, including synaptic plasticity and hippocampus-dependent cognitive processes in neuropathic pain.https://www.mdpi.com/1422-0067/22/23/12779synaptamideN-docosahexaenoylethanolamineneuropathic painspared nerve injuryhippocampusneuroinflammation |
| spellingShingle | Anna Tyrtyshnaia Anatoly Bondar Sophia Konovalova Igor Manzhulo Synaptamide Improves Cognitive Functions and Neuronal Plasticity in Neuropathic Pain International Journal of Molecular Sciences synaptamide N-docosahexaenoylethanolamine neuropathic pain spared nerve injury hippocampus neuroinflammation |
| title | Synaptamide Improves Cognitive Functions and Neuronal Plasticity in Neuropathic Pain |
| title_full | Synaptamide Improves Cognitive Functions and Neuronal Plasticity in Neuropathic Pain |
| title_fullStr | Synaptamide Improves Cognitive Functions and Neuronal Plasticity in Neuropathic Pain |
| title_full_unstemmed | Synaptamide Improves Cognitive Functions and Neuronal Plasticity in Neuropathic Pain |
| title_short | Synaptamide Improves Cognitive Functions and Neuronal Plasticity in Neuropathic Pain |
| title_sort | synaptamide improves cognitive functions and neuronal plasticity in neuropathic pain |
| topic | synaptamide N-docosahexaenoylethanolamine neuropathic pain spared nerve injury hippocampus neuroinflammation |
| url | https://www.mdpi.com/1422-0067/22/23/12779 |
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