BRG1: Promoter or Suppressor of Cancer? The Outcome of BRG1’s Interaction with Specific Cellular Pathways

BRG1: Promoter or Suppressor of Cancer? The Outcome of BRG1’s Interaction with Specific Cellular Pathways

BRG1 is one of two catalytic subunits of the SWI/SNF ATP-dependent chromatin-remodeling complex. In cancer, it has been hypothesized that BRG1 acts as a tumor suppressor. Further study has shown that, under certain circumstances, BRG1 acts as an oncogene. Targeted knockout of BRG1 has proven success...

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Bibliographic Details
Main Authors: Aaron Shaykevich, Isaac Silverman, Gargi Bandyopadhyaya, Radhashree Maitra
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
BRG1
SMARCA4
cancer
autophagy
apoptosis
PRMT5
Online Access:https://www.mdpi.com/1422-0067/24/3/2869

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