Iron Chelation Therapy in COVID-19 Infection
The recent outbreak of corona virus and coronavirus disease (COVID-19) caused by the SARS-CoV-2 virus is a global concern. Despite efforts to clarify the physiology and potential therapy, specific guidelines for the treatment of COVID-19 disease have yet to be established, and many therapeutic optio...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Faculty of Medicine Osijek
2022-11-01
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| Series: | Southeastern European Medical Journal |
| Subjects: | |
| Online Access: | http://seemedj.mefos.unios.hr/index.php/seemedj/article/view/246/141 |
| _version_ | 1798016442450313216 |
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| author | Irena Krajina Kmoniček Anja Tomić Josip Kocur |
| author_facet | Irena Krajina Kmoniček Anja Tomić Josip Kocur |
| author_sort | Irena Krajina Kmoniček |
| collection | DOAJ |
| description | The recent outbreak of corona virus and coronavirus disease (COVID-19) caused by the SARS-CoV-2 virus is a global concern. Despite efforts to clarify the physiology and potential therapy, specific guidelines for the treatment of COVID-19 disease have yet to be established, and many therapeutic options are under investigation. Accumulating evidence suggests that dysregulation of iron homeostasis contributes significantly to the pathogenesis of COVID-19 through its toxic effects by the formation of reactive oxygen species (ROS). This review focuses on summarizing the available literature and relevant studies conducted to date on the possible therapeutic effects of iron chelation therapy in the treatment of COVID-19 disease. Scientific databases (PubMed, Scopus, Google Scholar) were searched for relevant articles using the following keywords: COVID-19, SARS-CoV-2, coronavirus, clinical management, iron chelators/chelation. Research articles, reviews, research letters, case reports, and commentaries were considered. Although there is ample evidence of the potential beneficial effects of using iron chelators as adjuvant treatment in COVID-19, further research on this topic is needed. |
| first_indexed | 2024-04-11T15:49:36Z |
| format | Article |
| id | doaj.art-d9f9e97a88e14205afdcf95ab7edf5b9 |
| institution | Directory Open Access Journal |
| issn | 2459-9484 |
| language | English |
| last_indexed | 2024-04-11T15:49:36Z |
| publishDate | 2022-11-01 |
| publisher | Faculty of Medicine Osijek |
| record_format | Article |
| series | Southeastern European Medical Journal |
| spelling | doaj.art-d9f9e97a88e14205afdcf95ab7edf5b92022-12-22T04:15:22ZengFaculty of Medicine OsijekSoutheastern European Medical Journal2459-94842022-11-016275758410.26332/seemedj.v6i2.246Iron Chelation Therapy in COVID-19 InfectionIrena Krajina Kmoniček0https://orcid.org/0000-0002-0610-173XAnja Tomić1Josip Kocur2Department of Anesthesiology, Osijek University Hospital Centre, Osijek, CroatiaCommunity Health Centre Vinkovci, Vinkovci, CroatiaDepartment of Orthopedics and Traumatology, Osijek University Hospital Centre, Osijek, CroatiaThe recent outbreak of corona virus and coronavirus disease (COVID-19) caused by the SARS-CoV-2 virus is a global concern. Despite efforts to clarify the physiology and potential therapy, specific guidelines for the treatment of COVID-19 disease have yet to be established, and many therapeutic options are under investigation. Accumulating evidence suggests that dysregulation of iron homeostasis contributes significantly to the pathogenesis of COVID-19 through its toxic effects by the formation of reactive oxygen species (ROS). This review focuses on summarizing the available literature and relevant studies conducted to date on the possible therapeutic effects of iron chelation therapy in the treatment of COVID-19 disease. Scientific databases (PubMed, Scopus, Google Scholar) were searched for relevant articles using the following keywords: COVID-19, SARS-CoV-2, coronavirus, clinical management, iron chelators/chelation. Research articles, reviews, research letters, case reports, and commentaries were considered. Although there is ample evidence of the potential beneficial effects of using iron chelators as adjuvant treatment in COVID-19, further research on this topic is needed.http://seemedj.mefos.unios.hr/index.php/seemedj/article/view/246/141covid-19sars-cov-2iron chelating agentscovid-19 therapy |
| spellingShingle | Irena Krajina Kmoniček Anja Tomić Josip Kocur Iron Chelation Therapy in COVID-19 Infection Southeastern European Medical Journal covid-19 sars-cov-2 iron chelating agents covid-19 therapy |
| title | Iron Chelation Therapy in COVID-19 Infection |
| title_full | Iron Chelation Therapy in COVID-19 Infection |
| title_fullStr | Iron Chelation Therapy in COVID-19 Infection |
| title_full_unstemmed | Iron Chelation Therapy in COVID-19 Infection |
| title_short | Iron Chelation Therapy in COVID-19 Infection |
| title_sort | iron chelation therapy in covid 19 infection |
| topic | covid-19 sars-cov-2 iron chelating agents covid-19 therapy |
| url | http://seemedj.mefos.unios.hr/index.php/seemedj/article/view/246/141 |
| work_keys_str_mv | AT irenakrajinakmonicek ironchelationtherapyincovid19infection AT anjatomic ironchelationtherapyincovid19infection AT josipkocur ironchelationtherapyincovid19infection |