Effects of particle size on the triboelectrification phenomenon in pharmaceutical excipients: Experiments and multi-scale modeling
Particle sizes play a major role to mediate charge transfer, both between identical and different material surfaces. The study probes into the probable mechanism that actuates opposite polarities between two different size fractions of the same material by analyzing the charge transfer patterns of t...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-10-01
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| Series: | Asian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1818087616300319 |
| _version_ | 1818197119473811456 |
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| author | Raj Mukherjee Vipul Gupta Shivangi Naik Saurabh Sarkar Vinit Sharma Prasad Peri Bodhisattwa Chaudhuri |
| author_facet | Raj Mukherjee Vipul Gupta Shivangi Naik Saurabh Sarkar Vinit Sharma Prasad Peri Bodhisattwa Chaudhuri |
| author_sort | Raj Mukherjee |
| collection | DOAJ |
| description | Particle sizes play a major role to mediate charge transfer, both between identical and different material surfaces. The study probes into the probable mechanism that actuates opposite polarities between two different size fractions of the same material by analyzing the charge transfer patterns of two different sizes of microcrystalline cellulose (MCC). Quantum scale calculations confirmed alteration of charge transfer capacities due to variation of moisture content predicted by multiple surface and bulk analytical techniques. Discrete Element Method (DEM) based multi-scale computational models pertinent to predict charge transfer capacities were further implemented, and the results were in accordance to the experimental charge profiles. |
| first_indexed | 2024-12-12T01:44:54Z |
| format | Article |
| id | doaj.art-d9fd57fc1dcb49f2b4390647a67d7fe4 |
| institution | Directory Open Access Journal |
| issn | 1818-0876 |
| language | English |
| last_indexed | 2024-12-12T01:44:54Z |
| publishDate | 2016-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-d9fd57fc1dcb49f2b4390647a67d7fe42022-12-22T00:42:37ZengElsevierAsian Journal of Pharmaceutical Sciences1818-08762016-10-0111560361710.1016/j.ajps.2016.04.006Effects of particle size on the triboelectrification phenomenon in pharmaceutical excipients: Experiments and multi-scale modelingRaj Mukherjee0Vipul Gupta1Shivangi Naik2Saurabh Sarkar3Vinit Sharma4Prasad Peri5Bodhisattwa Chaudhuri6Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USADepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USADepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USADepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USAInstitute of Material Sciences, University of Connecticut, Storrs, CT 06269, USAMerck Sharp and Dohme, West Point, PA 19486, USADepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USAParticle sizes play a major role to mediate charge transfer, both between identical and different material surfaces. The study probes into the probable mechanism that actuates opposite polarities between two different size fractions of the same material by analyzing the charge transfer patterns of two different sizes of microcrystalline cellulose (MCC). Quantum scale calculations confirmed alteration of charge transfer capacities due to variation of moisture content predicted by multiple surface and bulk analytical techniques. Discrete Element Method (DEM) based multi-scale computational models pertinent to predict charge transfer capacities were further implemented, and the results were in accordance to the experimental charge profiles.http://www.sciencedirect.com/science/article/pii/S1818087616300319TribochargingWork functionExcipientDiscrete Element Modeling |
| spellingShingle | Raj Mukherjee Vipul Gupta Shivangi Naik Saurabh Sarkar Vinit Sharma Prasad Peri Bodhisattwa Chaudhuri Effects of particle size on the triboelectrification phenomenon in pharmaceutical excipients: Experiments and multi-scale modeling Asian Journal of Pharmaceutical Sciences Tribocharging Work function Excipient Discrete Element Modeling |
| title | Effects of particle size on the triboelectrification phenomenon in pharmaceutical excipients: Experiments and multi-scale modeling |
| title_full | Effects of particle size on the triboelectrification phenomenon in pharmaceutical excipients: Experiments and multi-scale modeling |
| title_fullStr | Effects of particle size on the triboelectrification phenomenon in pharmaceutical excipients: Experiments and multi-scale modeling |
| title_full_unstemmed | Effects of particle size on the triboelectrification phenomenon in pharmaceutical excipients: Experiments and multi-scale modeling |
| title_short | Effects of particle size on the triboelectrification phenomenon in pharmaceutical excipients: Experiments and multi-scale modeling |
| title_sort | effects of particle size on the triboelectrification phenomenon in pharmaceutical excipients experiments and multi scale modeling |
| topic | Tribocharging Work function Excipient Discrete Element Modeling |
| url | http://www.sciencedirect.com/science/article/pii/S1818087616300319 |
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