Phenolic Acids-Mediated Regulation of Molecular Targets in Ovarian Cancer: Current Understanding and Future Perspectives
Cancer is a global health concern with a dynamic rise in occurrence and one of the leading causes of mortality worldwide. Among different types of cancer, ovarian cancer (OC) is the seventh most diagnosed malignant tumor, while among the gynecological malignancies, it ranks third after cervical and...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/16/2/274 |
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| author | Nazia Nazam Nasimudeen R. Jabir Iftikhar Ahmad Saif A. Alharthy Mohd Shahnawaz Khan Rashid Ayub Shams Tabrez |
| author_facet | Nazia Nazam Nasimudeen R. Jabir Iftikhar Ahmad Saif A. Alharthy Mohd Shahnawaz Khan Rashid Ayub Shams Tabrez |
| author_sort | Nazia Nazam |
| collection | DOAJ |
| description | Cancer is a global health concern with a dynamic rise in occurrence and one of the leading causes of mortality worldwide. Among different types of cancer, ovarian cancer (OC) is the seventh most diagnosed malignant tumor, while among the gynecological malignancies, it ranks third after cervical and uterine cancer and sadly bears the highest mortality and worst prognosis. First-line treatments have included a variety of cytotoxic and synthetic chemotherapeutic medicines, but they have not been particularly effective in extending OC patients’ lives and are associated with side effects, recurrence risk, and drug resistance. Hence, a shift from synthetic to phytochemical-based agents is gaining popularity, and researchers are looking into alternative, cost-effective, and safer chemotherapeutic strategies. Lately, studies on the effectiveness of phenolic acids in ovarian cancer have sparked the scientific community’s interest because of their high bioavailability, safety profile, lesser side effects, and cost-effectiveness. Yet this is a road less explored and critically analyzed and lacks the credibility of the novel findings. Phenolic acids are a significant class of phytochemicals usually considered in the nonflavonoid category. The current review focused on the anticancer potential of phenolic acids with a special emphasis on chemoprevention and treatment of OC. We tried to summarize results from experimental, epidemiological, and clinical studies unraveling the benefits of various phenolic acids (hydroxybenzoic acid and hydroxycinnamic acid) in chemoprevention and as anticancer agents of clinical significance. |
| first_indexed | 2024-03-11T08:18:22Z |
| format | Article |
| id | doaj.art-d9fdf182ca1a4b76b43c71b360bc9632 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-11T08:18:22Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-d9fdf182ca1a4b76b43c71b360bc96322023-11-16T22:37:23ZengMDPI AGPharmaceuticals1424-82472023-02-0116227410.3390/ph16020274Phenolic Acids-Mediated Regulation of Molecular Targets in Ovarian Cancer: Current Understanding and Future PerspectivesNazia Nazam0Nasimudeen R. Jabir1Iftikhar Ahmad2Saif A. Alharthy3Mohd Shahnawaz Khan4Rashid Ayub5Shams Tabrez6Amity Institute of Molecular Medicine & Stem Cell Research, Amity University, Noida 201301, Uttar Pradesh, IndiaDepartment of Biochemistry, Centre for Research and Development, PRIST University, Vallam, Thanjavur 613403, Tamil Nadu, IndiaDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi ArabiaKing Fahd Medical Research Center, King Abdulaziz University, Jeddah 21362, Saudi ArabiaDepartment of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaTechnology and Innovation Unit, Department of Science, King Saud University, Riyadh 11451, Saudi ArabiaKing Fahd Medical Research Center, King Abdulaziz University, Jeddah 21362, Saudi ArabiaCancer is a global health concern with a dynamic rise in occurrence and one of the leading causes of mortality worldwide. Among different types of cancer, ovarian cancer (OC) is the seventh most diagnosed malignant tumor, while among the gynecological malignancies, it ranks third after cervical and uterine cancer and sadly bears the highest mortality and worst prognosis. First-line treatments have included a variety of cytotoxic and synthetic chemotherapeutic medicines, but they have not been particularly effective in extending OC patients’ lives and are associated with side effects, recurrence risk, and drug resistance. Hence, a shift from synthetic to phytochemical-based agents is gaining popularity, and researchers are looking into alternative, cost-effective, and safer chemotherapeutic strategies. Lately, studies on the effectiveness of phenolic acids in ovarian cancer have sparked the scientific community’s interest because of their high bioavailability, safety profile, lesser side effects, and cost-effectiveness. Yet this is a road less explored and critically analyzed and lacks the credibility of the novel findings. Phenolic acids are a significant class of phytochemicals usually considered in the nonflavonoid category. The current review focused on the anticancer potential of phenolic acids with a special emphasis on chemoprevention and treatment of OC. We tried to summarize results from experimental, epidemiological, and clinical studies unraveling the benefits of various phenolic acids (hydroxybenzoic acid and hydroxycinnamic acid) in chemoprevention and as anticancer agents of clinical significance.https://www.mdpi.com/1424-8247/16/2/274ellagic acidgallic acidovarian cancerphytochemicalsprotocatechuic acidsalicylic acid |
| spellingShingle | Nazia Nazam Nasimudeen R. Jabir Iftikhar Ahmad Saif A. Alharthy Mohd Shahnawaz Khan Rashid Ayub Shams Tabrez Phenolic Acids-Mediated Regulation of Molecular Targets in Ovarian Cancer: Current Understanding and Future Perspectives Pharmaceuticals ellagic acid gallic acid ovarian cancer phytochemicals protocatechuic acid salicylic acid |
| title | Phenolic Acids-Mediated Regulation of Molecular Targets in Ovarian Cancer: Current Understanding and Future Perspectives |
| title_full | Phenolic Acids-Mediated Regulation of Molecular Targets in Ovarian Cancer: Current Understanding and Future Perspectives |
| title_fullStr | Phenolic Acids-Mediated Regulation of Molecular Targets in Ovarian Cancer: Current Understanding and Future Perspectives |
| title_full_unstemmed | Phenolic Acids-Mediated Regulation of Molecular Targets in Ovarian Cancer: Current Understanding and Future Perspectives |
| title_short | Phenolic Acids-Mediated Regulation of Molecular Targets in Ovarian Cancer: Current Understanding and Future Perspectives |
| title_sort | phenolic acids mediated regulation of molecular targets in ovarian cancer current understanding and future perspectives |
| topic | ellagic acid gallic acid ovarian cancer phytochemicals protocatechuic acid salicylic acid |
| url | https://www.mdpi.com/1424-8247/16/2/274 |
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