Solid pseudopapillary neoplasm (SPN) of the pancreas: current understanding on its malignant potential and management
Abstract Solid pseudopapillary neoplasms (SPN) of the pancreas are presently recognized as low-grade malignant tumors that are frequently observed in young females. This tumor has a low incidence and is associated with an excellent prognosis following surgical resection. Typical SPNs primarily affec...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer
2024-03-01
|
| Series: | Discover Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s12672-024-00905-5 |
| _version_ | 1797247230740004864 |
|---|---|
| author | Xiaoyue Lu Hao Chen Taiping Zhang |
| author_facet | Xiaoyue Lu Hao Chen Taiping Zhang |
| author_sort | Xiaoyue Lu |
| collection | DOAJ |
| description | Abstract Solid pseudopapillary neoplasms (SPN) of the pancreas are presently recognized as low-grade malignant tumors that are frequently observed in young females. This tumor has a low incidence and is associated with an excellent prognosis following surgical resection. Typical SPNs primarily affect the pancreas and tend to have moderate or asymptomatic manifestations. Based on retrospective research, it is anticipated that patients with SPN can achieve disease-free survival, even in cases when metastasis is detected during inspection. However, the incidence of malignant SPN has been consistently underestimated, as evidenced by recent research findings. Malignancy of SPN primarily encompasses invasion and infiltration, metastasis, and recurrence after R0 resection. Imaging technologies such as Ultrasound, Computed Tomography, Magnetic Resonance Imaging, and Position Emission Tomography are capable of preliminarily identifying malignant SPN, which is primarily based on its invasive clinical features. Research on risk factors of malignant SPN revealed that larger tumor size, Ki-67 index, and several other parameters had significant correlations with invasive tumor behavior. Pathologic features of malignant SPNs overlay other pancreatic tumors, nevertheless they can provide valuable assistance in the process of diagnosis. Several confirmed specific pathologic biomarkers are related to its cellular origin, characteristic gene mutation, and cell proliferation. Considering the invasiveness of malignant SPN, it is imperative to enhance the comprehensiveness of its therapy. Tumor resection remains a suggested course of action in line with typical SPN, and additional lymph node dissection is seen as reasonable. Compared to benign SPNs, malignant SPNs have worse prognosis, underscoring the necessity of early identification and treatment in comprehensive medical centers to get improved clinical outcomes. |
| first_indexed | 2024-04-24T19:55:24Z |
| format | Article |
| id | doaj.art-d9fe72ad8101446a943b2267cf00cdd7 |
| institution | Directory Open Access Journal |
| issn | 2730-6011 |
| language | English |
| last_indexed | 2024-04-24T19:55:24Z |
| publishDate | 2024-03-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj.art-d9fe72ad8101446a943b2267cf00cdd72024-03-24T12:24:40ZengSpringerDiscover Oncology2730-60112024-03-0115111210.1007/s12672-024-00905-5Solid pseudopapillary neoplasm (SPN) of the pancreas: current understanding on its malignant potential and managementXiaoyue Lu0Hao Chen1Taiping Zhang2Peking Union Medical CollegeDepartment of General Surgery, Chinese Academy of Medical Sciences, Peking Union Medical College HospitalDepartment of General Surgery, Chinese Academy of Medical Sciences, Peking Union Medical College HospitalAbstract Solid pseudopapillary neoplasms (SPN) of the pancreas are presently recognized as low-grade malignant tumors that are frequently observed in young females. This tumor has a low incidence and is associated with an excellent prognosis following surgical resection. Typical SPNs primarily affect the pancreas and tend to have moderate or asymptomatic manifestations. Based on retrospective research, it is anticipated that patients with SPN can achieve disease-free survival, even in cases when metastasis is detected during inspection. However, the incidence of malignant SPN has been consistently underestimated, as evidenced by recent research findings. Malignancy of SPN primarily encompasses invasion and infiltration, metastasis, and recurrence after R0 resection. Imaging technologies such as Ultrasound, Computed Tomography, Magnetic Resonance Imaging, and Position Emission Tomography are capable of preliminarily identifying malignant SPN, which is primarily based on its invasive clinical features. Research on risk factors of malignant SPN revealed that larger tumor size, Ki-67 index, and several other parameters had significant correlations with invasive tumor behavior. Pathologic features of malignant SPNs overlay other pancreatic tumors, nevertheless they can provide valuable assistance in the process of diagnosis. Several confirmed specific pathologic biomarkers are related to its cellular origin, characteristic gene mutation, and cell proliferation. Considering the invasiveness of malignant SPN, it is imperative to enhance the comprehensiveness of its therapy. Tumor resection remains a suggested course of action in line with typical SPN, and additional lymph node dissection is seen as reasonable. Compared to benign SPNs, malignant SPNs have worse prognosis, underscoring the necessity of early identification and treatment in comprehensive medical centers to get improved clinical outcomes.https://doi.org/10.1007/s12672-024-00905-5Solid pseudopapillary neoplasmMalignant potentialIdentification and assessmentManagementPrognosis |
| spellingShingle | Xiaoyue Lu Hao Chen Taiping Zhang Solid pseudopapillary neoplasm (SPN) of the pancreas: current understanding on its malignant potential and management Discover Oncology Solid pseudopapillary neoplasm Malignant potential Identification and assessment Management Prognosis |
| title | Solid pseudopapillary neoplasm (SPN) of the pancreas: current understanding on its malignant potential and management |
| title_full | Solid pseudopapillary neoplasm (SPN) of the pancreas: current understanding on its malignant potential and management |
| title_fullStr | Solid pseudopapillary neoplasm (SPN) of the pancreas: current understanding on its malignant potential and management |
| title_full_unstemmed | Solid pseudopapillary neoplasm (SPN) of the pancreas: current understanding on its malignant potential and management |
| title_short | Solid pseudopapillary neoplasm (SPN) of the pancreas: current understanding on its malignant potential and management |
| title_sort | solid pseudopapillary neoplasm spn of the pancreas current understanding on its malignant potential and management |
| topic | Solid pseudopapillary neoplasm Malignant potential Identification and assessment Management Prognosis |
| url | https://doi.org/10.1007/s12672-024-00905-5 |
| work_keys_str_mv | AT xiaoyuelu solidpseudopapillaryneoplasmspnofthepancreascurrentunderstandingonitsmalignantpotentialandmanagement AT haochen solidpseudopapillaryneoplasmspnofthepancreascurrentunderstandingonitsmalignantpotentialandmanagement AT taipingzhang solidpseudopapillaryneoplasmspnofthepancreascurrentunderstandingonitsmalignantpotentialandmanagement |