Synergistic effects of complex drug combinations in colorectal cancer cells predicted by logical modelling

Drug combinations have been proposed to combat drug resistance in cancer, but due to the large number of possible drug targets, in vitro testing of all possible combinations of drugs is challenging. Computational models of a disease hold great promise as tools for prediction of response to treatment...

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Bibliographic Details
Main Authors: Evelina Folkesson, B. Cristoffer Sakshaug, Andrea D. Hoel, Geir Klinkenberg, Åsmund Flobak
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Systems Biology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fsysb.2023.1112831/full