Pathways of arsenic uptake and efflux
Arsenic is a non-essential, environmentally ubiquitous toxic metalloid. In response to this pervasive environmental challenge, organisms evolved mechanisms to confer resistance to arsenicals. Inorganic pentavalent arsenate is taken into most cells adventitiously by phosphate uptake systems. Similarl...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-05-01
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| Series: | Environment International |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412018326588 |
| _version_ | 1819092212051345408 |
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| author | Luis D. Garbinski Barry P. Rosen Jian Chen |
| author_facet | Luis D. Garbinski Barry P. Rosen Jian Chen |
| author_sort | Luis D. Garbinski |
| collection | DOAJ |
| description | Arsenic is a non-essential, environmentally ubiquitous toxic metalloid. In response to this pervasive environmental challenge, organisms evolved mechanisms to confer resistance to arsenicals. Inorganic pentavalent arsenate is taken into most cells adventitiously by phosphate uptake systems. Similarly, inorganic trivalent arsenite is taken into most cells adventitiously, primarily via aquaglyceroporins or sugar permeases. The most common strategy for tolerance to both inorganic and organic arsenicals is by efflux that extrude them from the cytosol. These efflux transporters span across kingdoms and belong to various families such as aquaglyceroporins, major facilitator superfamily (MFS) transporters, ATP-binding cassette (ABC) transporters and potentially novel, yet to be discovered families. This review will outline the properties and substrates of known arsenic transport systems, the current knowledge gaps in the field, and aims to provide insight into the importance of arsenic transport in the context of the global arsenic biogeocycle and human health. Keywords: Arsenic resistance, Arsenic permeases, Arsenite, Arsenate, Methylarsenite |
| first_indexed | 2024-12-21T22:52:01Z |
| format | Article |
| id | doaj.art-da002e12fd1d4fe790e6218d5790964f |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-12-21T22:52:01Z |
| publishDate | 2019-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-da002e12fd1d4fe790e6218d5790964f2022-12-21T18:47:34ZengElsevierEnvironment International0160-41202019-05-01126585597Pathways of arsenic uptake and effluxLuis D. Garbinski0Barry P. Rosen1Jian Chen2Department of Cellular Biology and Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USADepartment of Cellular Biology and Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USACorresponding author at: Florida International University, Herbert Wertheim College of Medicine, 11200 SW 8th Street, Miami, FL 33199, USA.; Department of Cellular Biology and Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USAArsenic is a non-essential, environmentally ubiquitous toxic metalloid. In response to this pervasive environmental challenge, organisms evolved mechanisms to confer resistance to arsenicals. Inorganic pentavalent arsenate is taken into most cells adventitiously by phosphate uptake systems. Similarly, inorganic trivalent arsenite is taken into most cells adventitiously, primarily via aquaglyceroporins or sugar permeases. The most common strategy for tolerance to both inorganic and organic arsenicals is by efflux that extrude them from the cytosol. These efflux transporters span across kingdoms and belong to various families such as aquaglyceroporins, major facilitator superfamily (MFS) transporters, ATP-binding cassette (ABC) transporters and potentially novel, yet to be discovered families. This review will outline the properties and substrates of known arsenic transport systems, the current knowledge gaps in the field, and aims to provide insight into the importance of arsenic transport in the context of the global arsenic biogeocycle and human health. Keywords: Arsenic resistance, Arsenic permeases, Arsenite, Arsenate, Methylarsenitehttp://www.sciencedirect.com/science/article/pii/S0160412018326588 |
| spellingShingle | Luis D. Garbinski Barry P. Rosen Jian Chen Pathways of arsenic uptake and efflux Environment International |
| title | Pathways of arsenic uptake and efflux |
| title_full | Pathways of arsenic uptake and efflux |
| title_fullStr | Pathways of arsenic uptake and efflux |
| title_full_unstemmed | Pathways of arsenic uptake and efflux |
| title_short | Pathways of arsenic uptake and efflux |
| title_sort | pathways of arsenic uptake and efflux |
| url | http://www.sciencedirect.com/science/article/pii/S0160412018326588 |
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