Lipid metabolism: the potential targets for toxoplasmosis treatment
Abstract Toxoplasmosis is a zoonosis caused by Toxoplasma gondii (T. gondii). The current treatment for toxoplasmosis remains constrained due to the absence of pharmaceutical interventions. Thus, the pursuit of more efficient targets is of great importance. Lipid metabolism in T. gondii, including f...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-03-01
|
| Series: | Parasites & Vectors |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13071-024-06213-9 |
| _version_ | 1797266946511601664 |
|---|---|
| author | Tian-Yi He Ye-Tian Li Zhen-Di Liu Hao Cheng Yi-Feng Bao Ji-Li Zhang |
| author_facet | Tian-Yi He Ye-Tian Li Zhen-Di Liu Hao Cheng Yi-Feng Bao Ji-Li Zhang |
| author_sort | Tian-Yi He |
| collection | DOAJ |
| description | Abstract Toxoplasmosis is a zoonosis caused by Toxoplasma gondii (T. gondii). The current treatment for toxoplasmosis remains constrained due to the absence of pharmaceutical interventions. Thus, the pursuit of more efficient targets is of great importance. Lipid metabolism in T. gondii, including fatty acid metabolism, phospholipid metabolism, and neutral lipid metabolism, assumes a crucial function in T. gondii because those pathways are largely involved in the formation of the membranous structure and cellular processes such as division, invasion, egress, replication, and apoptosis. The inhibitors of T. gondii’s lipid metabolism can directly lead to the disturbance of various lipid component levels and serious destruction of membrane structure, ultimately leading to the death of the parasites. In this review, the specific lipid metabolism pathways, correlative enzymes, and inhibitors of lipid metabolism of T. gondii are elaborated in detail to generate novel ideas for the development of anti-T. gondii drugs that target the parasites’ lipid metabolism. Graphical abstract |
| first_indexed | 2024-04-25T01:08:46Z |
| format | Article |
| id | doaj.art-da00e4619afd49a6bce0d0f2cc383bd1 |
| institution | Directory Open Access Journal |
| issn | 1756-3305 |
| language | English |
| last_indexed | 2024-04-25T01:08:46Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Parasites & Vectors |
| spelling | doaj.art-da00e4619afd49a6bce0d0f2cc383bd12024-03-10T12:07:00ZengBMCParasites & Vectors1756-33052024-03-0117111310.1186/s13071-024-06213-9Lipid metabolism: the potential targets for toxoplasmosis treatmentTian-Yi He0Ye-Tian Li1Zhen-Di Liu2Hao Cheng3Yi-Feng Bao4Ji-Li Zhang5Health Science Center, Ningbo UniversityHealth Science Center, Ningbo UniversityHealth Science Center, Ningbo UniversityHealth Science Center, Ningbo UniversityHealth Science Center, Ningbo UniversityHealth Science Center, Ningbo UniversityAbstract Toxoplasmosis is a zoonosis caused by Toxoplasma gondii (T. gondii). The current treatment for toxoplasmosis remains constrained due to the absence of pharmaceutical interventions. Thus, the pursuit of more efficient targets is of great importance. Lipid metabolism in T. gondii, including fatty acid metabolism, phospholipid metabolism, and neutral lipid metabolism, assumes a crucial function in T. gondii because those pathways are largely involved in the formation of the membranous structure and cellular processes such as division, invasion, egress, replication, and apoptosis. The inhibitors of T. gondii’s lipid metabolism can directly lead to the disturbance of various lipid component levels and serious destruction of membrane structure, ultimately leading to the death of the parasites. In this review, the specific lipid metabolism pathways, correlative enzymes, and inhibitors of lipid metabolism of T. gondii are elaborated in detail to generate novel ideas for the development of anti-T. gondii drugs that target the parasites’ lipid metabolism. Graphical abstracthttps://doi.org/10.1186/s13071-024-06213-9Toxoplasma gondiiToxoplasmosisLipid metabolismFatty acidsPhospholipidsCholesterol |
| spellingShingle | Tian-Yi He Ye-Tian Li Zhen-Di Liu Hao Cheng Yi-Feng Bao Ji-Li Zhang Lipid metabolism: the potential targets for toxoplasmosis treatment Parasites & Vectors Toxoplasma gondii Toxoplasmosis Lipid metabolism Fatty acids Phospholipids Cholesterol |
| title | Lipid metabolism: the potential targets for toxoplasmosis treatment |
| title_full | Lipid metabolism: the potential targets for toxoplasmosis treatment |
| title_fullStr | Lipid metabolism: the potential targets for toxoplasmosis treatment |
| title_full_unstemmed | Lipid metabolism: the potential targets for toxoplasmosis treatment |
| title_short | Lipid metabolism: the potential targets for toxoplasmosis treatment |
| title_sort | lipid metabolism the potential targets for toxoplasmosis treatment |
| topic | Toxoplasma gondii Toxoplasmosis Lipid metabolism Fatty acids Phospholipids Cholesterol |
| url | https://doi.org/10.1186/s13071-024-06213-9 |
| work_keys_str_mv | AT tianyihe lipidmetabolismthepotentialtargetsfortoxoplasmosistreatment AT yetianli lipidmetabolismthepotentialtargetsfortoxoplasmosistreatment AT zhendiliu lipidmetabolismthepotentialtargetsfortoxoplasmosistreatment AT haocheng lipidmetabolismthepotentialtargetsfortoxoplasmosistreatment AT yifengbao lipidmetabolismthepotentialtargetsfortoxoplasmosistreatment AT jilizhang lipidmetabolismthepotentialtargetsfortoxoplasmosistreatment |