Tenascin-C expression contributes to pediatric brainstem glioma tumor phenotype and represents a novel biomarker of disease

Tenascin-C expression contributes to pediatric brainstem glioma tumor phenotype and represents a novel biomarker of disease

Abstract Diffuse intrinsic pontine glioma (DIPG), an infiltrative, high grade glioma (HGG) affecting young children, has the highest mortality rate of all pediatric cancers. Despite treatment, average survival is less than twelve months, and five-year survival under 5%. We previously detected increa...

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Bibliographic Details
Main Authors: J. Qi, D. R. Esfahani, T. Huang, P. Ozark, E. Bartom, R. Hashizume, E. R. Bonner, S. An, C. M. Horbinski, C. D. James, A. M. Saratsis
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Acta Neuropathologica Communications
Subjects:
Tenascin-C
Diffuse midline glioma
Diffuse intrinsic pontine glioma (DIPG)
Histone H3 mutation (H3K27 M)
Online Access:http://link.springer.com/article/10.1186/s40478-019-0727-1

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http://link.springer.com/article/10.1186/s40478-019-0727-1

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