Tenascin-C expression contributes to pediatric brainstem glioma tumor phenotype and represents a novel biomarker of disease
Abstract Diffuse intrinsic pontine glioma (DIPG), an infiltrative, high grade glioma (HGG) affecting young children, has the highest mortality rate of all pediatric cancers. Despite treatment, average survival is less than twelve months, and five-year survival under 5%. We previously detected increa...
Main Authors: | J. Qi, D. R. Esfahani, T. Huang, P. Ozark, E. Bartom, R. Hashizume, E. R. Bonner, S. An, C. M. Horbinski, C. D. James, A. M. Saratsis |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2019-05-01
|
Series: | Acta Neuropathologica Communications |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s40478-019-0727-1 |
Similar Items
-
Detection of Histone H3 mutations in cerebrospinal fluid-derived tumor DNA from children with diffuse midline glioma
by: Tina Y. Huang, et al.
Published: (2017-04-01) -
New Developments in the Pathogenesis, Therapeutic Targeting, and Treatment of H3K27M-Mutant Diffuse Midline Glioma
by: Davis P. Argersinger, et al.
Published: (2021-10-01) -
Epigenetic programming of pediatric high-grade glioma: Pushing beyond proof of concept to clinical benefit
by: Andrew Groves, et al.
Published: (2022-12-01) -
A longitudinally extensive H3 K27M-mutant diffuse midline
glioma in an elderly patient clinically mimicking central nervous
system inflammation: a case report
by: Kristof Babarczy, et al.
Published: (2021-01-01) -
H3K27me3 in Diffuse Midline Glioma and Epithelial Ovarian Cancer: Opposing Epigenetic Changes Leading to the Same Poor Outcomes
by: Charles A. Day, et al.
Published: (2022-10-01)