Movement Speed-Accuracy Trade-Off in Parkinson's Disease
Patients with Parkinson's disease (PD) often have difficulties generating rhythmic movements, and also difficulties on movement adjustments to accuracy constraints. In the reciprocal aiming task, maintaining a high accuracy comes with the cost of diminished movement speed, whereas increasing mo...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-10-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2018.00897/full |
| _version_ | 1818198414326759424 |
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| author | Laure Fernandez Raoul Huys Johann Issartel Jean-Philippe Azulay Alexandre Eusebio Alexandre Eusebio |
| author_facet | Laure Fernandez Raoul Huys Johann Issartel Jean-Philippe Azulay Alexandre Eusebio Alexandre Eusebio |
| author_sort | Laure Fernandez |
| collection | DOAJ |
| description | Patients with Parkinson's disease (PD) often have difficulties generating rhythmic movements, and also difficulties on movement adjustments to accuracy constraints. In the reciprocal aiming task, maintaining a high accuracy comes with the cost of diminished movement speed, whereas increasing movement speed disrupts end-point accuracy, a phenomenon well known as the speed-accuracy trade-off. The aim of this study was to examine how PD impacts speed-accuracy trade-off during rhythmic aiming movements by studying the structural kinematic movement organization and to determine the influence of dopamine replacement therapy on continuous movement speed and accuracy. Eighteen patients with advanced idiopathic Parkinson's disease performed a reciprocal aiming task, where the difficulty of the task was manipulated through target width. All patients were tested in two different sessions: ON-medication and OFF-medication state. A control group composed of healthy age-matched participants was also included in the study. The following variables were used for the analyses: Movement time, Error rate, effective target width, and Performance Index. Percentage of acceleration time and percentage of non-linearity were completed with kinematics patterns description using Rayleigh-Duffing model. Both groups traded off speed against accuracy as the constraints pertaining to the latter increased. The trade-off was more pronounced with the PD patients. Dopamine therapy allowed the PD patients to move faster, but at the cost of movement accuracy. Surprisingly, the structural kinematic organization did not differ across group nor across medication condition. These results suggest that PD patients, when involved in a reciprocal aiming task, are able to produce rhythmic movements. PD patients' overall slowing down seems to reflect a global adaptation to the disease in the absence of a structurally altered kinematic organization. |
| first_indexed | 2024-12-12T02:05:29Z |
| format | Article |
| id | doaj.art-da0356d774fa494a8e6d1e91ba027956 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-12T02:05:29Z |
| publishDate | 2018-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-da0356d774fa494a8e6d1e91ba0279562022-12-22T00:42:04ZengFrontiers Media S.A.Frontiers in Neurology1664-22952018-10-01910.3389/fneur.2018.00897409613Movement Speed-Accuracy Trade-Off in Parkinson's DiseaseLaure Fernandez0Raoul Huys1Johann Issartel2Jean-Philippe Azulay3Alexandre Eusebio4Alexandre Eusebio5Aix-Marseille Université, CNRS, ISM, Marseille, FranceUniversité de Toulouse, UMR 5549 CERCO (Centre de Recherche Cerveau et Cognition), UPS, CNRS, Toulouse, FranceMultisensory Motor Learning Lab, School of Health and Human Performance, Dublin City University, Dublin, IrelandAix-Marseille Université, APHM, CHU Timone, Department of Neurology and Movement Disorders, Marseille, FranceAix-Marseille Université, APHM, CHU Timone, Department of Neurology and Movement Disorders, Marseille, FranceAix-Marseille Université, CNRS, UMR 7289, Institut de Neurosciences de la Timone, Marseille, FrancePatients with Parkinson's disease (PD) often have difficulties generating rhythmic movements, and also difficulties on movement adjustments to accuracy constraints. In the reciprocal aiming task, maintaining a high accuracy comes with the cost of diminished movement speed, whereas increasing movement speed disrupts end-point accuracy, a phenomenon well known as the speed-accuracy trade-off. The aim of this study was to examine how PD impacts speed-accuracy trade-off during rhythmic aiming movements by studying the structural kinematic movement organization and to determine the influence of dopamine replacement therapy on continuous movement speed and accuracy. Eighteen patients with advanced idiopathic Parkinson's disease performed a reciprocal aiming task, where the difficulty of the task was manipulated through target width. All patients were tested in two different sessions: ON-medication and OFF-medication state. A control group composed of healthy age-matched participants was also included in the study. The following variables were used for the analyses: Movement time, Error rate, effective target width, and Performance Index. Percentage of acceleration time and percentage of non-linearity were completed with kinematics patterns description using Rayleigh-Duffing model. Both groups traded off speed against accuracy as the constraints pertaining to the latter increased. The trade-off was more pronounced with the PD patients. Dopamine therapy allowed the PD patients to move faster, but at the cost of movement accuracy. Surprisingly, the structural kinematic organization did not differ across group nor across medication condition. These results suggest that PD patients, when involved in a reciprocal aiming task, are able to produce rhythmic movements. PD patients' overall slowing down seems to reflect a global adaptation to the disease in the absence of a structurally altered kinematic organization.https://www.frontiersin.org/article/10.3389/fneur.2018.00897/fullparkinson's diseasedopaminespeed-accuracy trade-offrhythmicitygoal-directed movement |
| spellingShingle | Laure Fernandez Raoul Huys Johann Issartel Jean-Philippe Azulay Alexandre Eusebio Alexandre Eusebio Movement Speed-Accuracy Trade-Off in Parkinson's Disease Frontiers in Neurology parkinson's disease dopamine speed-accuracy trade-off rhythmicity goal-directed movement |
| title | Movement Speed-Accuracy Trade-Off in Parkinson's Disease |
| title_full | Movement Speed-Accuracy Trade-Off in Parkinson's Disease |
| title_fullStr | Movement Speed-Accuracy Trade-Off in Parkinson's Disease |
| title_full_unstemmed | Movement Speed-Accuracy Trade-Off in Parkinson's Disease |
| title_short | Movement Speed-Accuracy Trade-Off in Parkinson's Disease |
| title_sort | movement speed accuracy trade off in parkinson s disease |
| topic | parkinson's disease dopamine speed-accuracy trade-off rhythmicity goal-directed movement |
| url | https://www.frontiersin.org/article/10.3389/fneur.2018.00897/full |
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