Psychological suppressive profile and autoantibodies variability in women living with breast cancer: A prospective cross-sectional study
Breast cancer (BC) is a leading cause of women's morbimortality worldwide. Unfortunately, attempts to predict women's susceptibility to developing BC well before it becomes symptomatic, based on their genetic, family, and reproductive background have proved unsatisfactory. Here we analyze...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844022021715 |
| _version_ | 1811247792366026752 |
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| author | Tania Romo-González Antonia Barranca-Enríquez Rosalba León-Díaz Enrique Del Callejo-Canal Gabriel Gutiérrez-Ospina Angela María Jimenez Urrego Cristina Bolaños Alejandro Botero Carvajal |
| author_facet | Tania Romo-González Antonia Barranca-Enríquez Rosalba León-Díaz Enrique Del Callejo-Canal Gabriel Gutiérrez-Ospina Angela María Jimenez Urrego Cristina Bolaños Alejandro Botero Carvajal |
| author_sort | Tania Romo-González |
| collection | DOAJ |
| description | Breast cancer (BC) is a leading cause of women's morbimortality worldwide. Unfortunately, attempts to predict women's susceptibility to developing BC well before it becomes symptomatic, based on their genetic, family, and reproductive background have proved unsatisfactory. Here we analyze the matching of personality traits and protein serum profiles to predict women's susceptibility to developing cancer. We conducted a prospective study among 150 women (aged 18–70 years), who were distributed into three groups (n = 50): women without breast pathology and women diagnosed with BC or benign breast pathology. Psychological data were obtained through standardized psychological tests and serum protein samples were analyzed through semiquantitative protein immunoblotting. The matching for psychological and immunological profiles was constructed from these data using a mathematical generalized linear model.The model predicted that women who have stronger associations between high-intensity stress responses, emotional containment, and an increased number and reduced variability of serum proteins (detected by IgG autoantibodies) have the greatest susceptibility to develop BC before the disease has manifested clinically. Hence, the present study endorses the possibility of using psychological and biochemical tests in combination to increase the possibility of identifying women at risk of developing BC before the disease shows clinical manifestations. A longitudinal study must be instrumented to test the prediction ability of the instrument in real scenarios. Trial registration: Committee of Ethical Research of the Hospital General de México “Dr. Eduardo Liceaga,” Ministry of Health (DI/12/111/03/064). |
| first_indexed | 2024-04-12T15:15:42Z |
| format | Article |
| id | doaj.art-da077bae64ba48e0b815bbab1bb3095a |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-12T15:15:42Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-da077bae64ba48e0b815bbab1bb3095a2022-12-22T03:27:38ZengElsevierHeliyon2405-84402022-10-01810e10883Psychological suppressive profile and autoantibodies variability in women living with breast cancer: A prospective cross-sectional studyTania Romo-González0Antonia Barranca-Enríquez1Rosalba León-Díaz2Enrique Del Callejo-Canal3Gabriel Gutiérrez-Ospina4Angela María Jimenez Urrego5Cristina Bolaños6Alejandro Botero Carvajal7Biology and Integral Health Area of the Biological Research Institute of the Universidad Veracruzana. Dr. Luis Castelazo Ayala S/N, Industrial Animas, Rubí Animas, C.P. 91190, Xalapa-Enríquez, Veracruz, Mexico; Corresponding author.Center for Health Studies and Services, in the Universidad Veracruzana at Veracruz, Veracruz, MexicoBiology and Integral Health Area of the Biological Research Institute of the Universidad Veracruzana. Dr. Luis Castelazo Ayala S/N, Industrial Animas, Rubí Animas, C.P. 91190, Xalapa-Enríquez, Veracruz, MexicoBiology and Integral Health Area of the Biological Research Institute of the Universidad Veracruzana. Dr. Luis Castelazo Ayala S/N, Industrial Animas, Rubí Animas, C.P. 91190, Xalapa-Enríquez, Veracruz, MexicoDepartment of Cell Biology and Physiology in the Institute for Biomedical Research of the National Autonomous University of Mexico, Mexico City, MexicoPsychology Program, Faculty of Human and Social Sciences, Universidad de San Buenaventura Cali, Cali, ColombiaMedicine Program, Fundación Universitaria San Martin, Pasto, ColombiaPsychology Program, Faculty of Health, Universidad Santiago de Cali, Cali, ColombiaBreast cancer (BC) is a leading cause of women's morbimortality worldwide. Unfortunately, attempts to predict women's susceptibility to developing BC well before it becomes symptomatic, based on their genetic, family, and reproductive background have proved unsatisfactory. Here we analyze the matching of personality traits and protein serum profiles to predict women's susceptibility to developing cancer. We conducted a prospective study among 150 women (aged 18–70 years), who were distributed into three groups (n = 50): women without breast pathology and women diagnosed with BC or benign breast pathology. Psychological data were obtained through standardized psychological tests and serum protein samples were analyzed through semiquantitative protein immunoblotting. The matching for psychological and immunological profiles was constructed from these data using a mathematical generalized linear model.The model predicted that women who have stronger associations between high-intensity stress responses, emotional containment, and an increased number and reduced variability of serum proteins (detected by IgG autoantibodies) have the greatest susceptibility to develop BC before the disease has manifested clinically. Hence, the present study endorses the possibility of using psychological and biochemical tests in combination to increase the possibility of identifying women at risk of developing BC before the disease shows clinical manifestations. A longitudinal study must be instrumented to test the prediction ability of the instrument in real scenarios. Trial registration: Committee of Ethical Research of the Hospital General de México “Dr. Eduardo Liceaga,” Ministry of Health (DI/12/111/03/064).http://www.sciencedirect.com/science/article/pii/S2405844022021715Breast cancerIgG autoantibodiesPersonality traitsPrognostic toolPsycho-immune network |
| spellingShingle | Tania Romo-González Antonia Barranca-Enríquez Rosalba León-Díaz Enrique Del Callejo-Canal Gabriel Gutiérrez-Ospina Angela María Jimenez Urrego Cristina Bolaños Alejandro Botero Carvajal Psychological suppressive profile and autoantibodies variability in women living with breast cancer: A prospective cross-sectional study Heliyon Breast cancer IgG autoantibodies Personality traits Prognostic tool Psycho-immune network |
| title | Psychological suppressive profile and autoantibodies variability in women living with breast cancer: A prospective cross-sectional study |
| title_full | Psychological suppressive profile and autoantibodies variability in women living with breast cancer: A prospective cross-sectional study |
| title_fullStr | Psychological suppressive profile and autoantibodies variability in women living with breast cancer: A prospective cross-sectional study |
| title_full_unstemmed | Psychological suppressive profile and autoantibodies variability in women living with breast cancer: A prospective cross-sectional study |
| title_short | Psychological suppressive profile and autoantibodies variability in women living with breast cancer: A prospective cross-sectional study |
| title_sort | psychological suppressive profile and autoantibodies variability in women living with breast cancer a prospective cross sectional study |
| topic | Breast cancer IgG autoantibodies Personality traits Prognostic tool Psycho-immune network |
| url | http://www.sciencedirect.com/science/article/pii/S2405844022021715 |
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