Synthesis, Cytotoxicity and Molecular Docking Studies of the 9-Substituted 5-Styryltetrazolo[1,5-c]quinazoline Derivatives

Synthesis, Cytotoxicity and Molecular Docking Studies of the 9-Substituted 5-Styryltetrazolo[1,5-c]quinazoline Derivatives

In this paper, we describe the synthesis of the 5-styryltetrazolo[1,5-c]quinazolines substituted at the 9-position with a 4-fluorophenyl ring directly or via a conjugated π-spacer (C=C or C≡C bond) based on the 6-bromo-4-chloro-2-styrylquinazoline scaffold. The structures of the synthesized compound...

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Bibliographic Details
Main Authors: Malose J. Mphahlele, Samantha Gildenhuys, Nishal Parbhoo
Format: Article
Language:English
Published: MDPI AG 2017-10-01
Series:Molecules
Subjects:
9-bromo-5-styryltetrazolo[1,5-c]quinazoline
cross-coupling
9-carbo–substituted 5-styryltetrazolo[1,5-c]quinazolines
cytotoxicity
molecular docking
Online Access:https://www.mdpi.com/1420-3049/22/11/1719

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