Fertility Rate and Sperm DNA Fragmentation Index following Varicocelectomy in Primary Infertile Men with Clinical Varicocele: A Prospective Longitudinal Study
Background: Varicocele is one of the most common treatable causes of male infertility, and its treatment may bebeneficial for fertility. This study aimed to evaluate fertility rate and DNA fragmentation index (DFI) following varicocelectomyin primary infertile men with clinical varicocele.Materials...
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| Format: | Article |
| Language: | English |
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Royan Institute (ACECR), Tehran
2024-04-01
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| Series: | International Journal of Fertility and Sterility |
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| Online Access: | https://www.ijfs.ir/article_708784_567a818ec34b80c6b5cf14a8d3f4e056.pdf |
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| author | Ali Hamidi Madani Mohammad Pakdaman Gholamreza Mokhtari Ehsan Kazemnezhad Mohammad Hamidi Madani Ali Fathollahi Nadia Rastjou Herfeh Roozbeh Roohinezhad |
| author_facet | Ali Hamidi Madani Mohammad Pakdaman Gholamreza Mokhtari Ehsan Kazemnezhad Mohammad Hamidi Madani Ali Fathollahi Nadia Rastjou Herfeh Roozbeh Roohinezhad |
| author_sort | Ali Hamidi Madani |
| collection | DOAJ |
| description | Background: Varicocele is one of the most common treatable causes of male infertility, and its treatment may bebeneficial for fertility. This study aimed to evaluate fertility rate and DNA fragmentation index (DFI) following varicocelectomyin primary infertile men with clinical varicocele.Materials and Methods: This prospective longitudinal study was conducted on primary infertility men, in a tertiarycenter from December 2018 to December 2019 with one-year follow-up. Data of the semen parameters, DFI (%), andfertility rate were gathered before, as well as 4 and 12 months after undergoing varicocelectomy. For data analysis,SPSS software and analytical test were used.Results: Out of 76 patients who were analyzed, 22 (29%) became fertile and 54 (71%) remained infertile. Semenparameters and DFI (%) were improved significantly following varicocelectomy (P<0.001). Smoking history, occupationalheated exposure, body mass index (BMI), and infertility duration were determined as predictors associatedwith fertility status (P<0.05).Conclusion: Although varicocele repair improved the DFI, the fertility rate was achieved in less than one-third ofpatients; it seems that the other parameters, such as the history of smoking, occupational heated exposure, overweight,and duration of infertility should be considered as predictors of fertility status, in primary infertile men who are a candidatefor varicocelectomy. |
| first_indexed | 2024-03-07T23:55:20Z |
| format | Article |
| id | doaj.art-da0bc2ba49154c958916e3840e6b353f |
| institution | Directory Open Access Journal |
| issn | 2008-076X 2008-0778 |
| language | English |
| last_indexed | 2024-03-07T23:55:20Z |
| publishDate | 2024-04-01 |
| publisher | Royan Institute (ACECR), Tehran |
| record_format | Article |
| series | International Journal of Fertility and Sterility |
| spelling | doaj.art-da0bc2ba49154c958916e3840e6b353f2024-02-18T08:39:20ZengRoyan Institute (ACECR), TehranInternational Journal of Fertility and Sterility2008-076X2008-07782024-04-0118216717210.22074/ijfs.2023.1990486.1441708784Fertility Rate and Sperm DNA Fragmentation Index following Varicocelectomy in Primary Infertile Men with Clinical Varicocele: A Prospective Longitudinal StudyAli Hamidi Madani0Mohammad Pakdaman1Gholamreza Mokhtari2Ehsan Kazemnezhad3Mohammad Hamidi Madani4Ali Fathollahi5Nadia Rastjou Herfeh6Roozbeh Roohinezhad7Urology Research Center, Razi Hospital, Guilan University of Medical Sciences, Rasht, IranUrology Research Center, Razi Hospital, Guilan University of Medical Sciences, Rasht, IranUrology Research Center, Razi Hospital, Guilan University of Medical Sciences, Rasht, IranUrology Research Center, Razi Hospital, Guilan University of Medical Sciences, Rasht, IranDepartment of Urology, Labbafinejad Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranTehran university of medical sciencePars Hospital, Rasht, IranUrology Research Center, Razi Hospital, Guilan University of Medical Sciences, Rasht, IranDepartment of Urology, Hasheminejad Kidney Center, Iran University of Medical Sciences, Tehran, IranBackground: Varicocele is one of the most common treatable causes of male infertility, and its treatment may bebeneficial for fertility. This study aimed to evaluate fertility rate and DNA fragmentation index (DFI) following varicocelectomyin primary infertile men with clinical varicocele.Materials and Methods: This prospective longitudinal study was conducted on primary infertility men, in a tertiarycenter from December 2018 to December 2019 with one-year follow-up. Data of the semen parameters, DFI (%), andfertility rate were gathered before, as well as 4 and 12 months after undergoing varicocelectomy. For data analysis,SPSS software and analytical test were used.Results: Out of 76 patients who were analyzed, 22 (29%) became fertile and 54 (71%) remained infertile. Semenparameters and DFI (%) were improved significantly following varicocelectomy (P<0.001). Smoking history, occupationalheated exposure, body mass index (BMI), and infertility duration were determined as predictors associatedwith fertility status (P<0.05).Conclusion: Although varicocele repair improved the DFI, the fertility rate was achieved in less than one-third ofpatients; it seems that the other parameters, such as the history of smoking, occupational heated exposure, overweight,and duration of infertility should be considered as predictors of fertility status, in primary infertile men who are a candidatefor varicocelectomy.https://www.ijfs.ir/article_708784_567a818ec34b80c6b5cf14a8d3f4e056.pdfdna fragmentationinfertilitysemen analysisvaricocelevaricocelecto |
| spellingShingle | Ali Hamidi Madani Mohammad Pakdaman Gholamreza Mokhtari Ehsan Kazemnezhad Mohammad Hamidi Madani Ali Fathollahi Nadia Rastjou Herfeh Roozbeh Roohinezhad Fertility Rate and Sperm DNA Fragmentation Index following Varicocelectomy in Primary Infertile Men with Clinical Varicocele: A Prospective Longitudinal Study International Journal of Fertility and Sterility dna fragmentation infertility semen analysis varicocele varicocelecto |
| title | Fertility Rate and Sperm DNA Fragmentation Index following Varicocelectomy in Primary Infertile Men with Clinical Varicocele: A Prospective Longitudinal Study |
| title_full | Fertility Rate and Sperm DNA Fragmentation Index following Varicocelectomy in Primary Infertile Men with Clinical Varicocele: A Prospective Longitudinal Study |
| title_fullStr | Fertility Rate and Sperm DNA Fragmentation Index following Varicocelectomy in Primary Infertile Men with Clinical Varicocele: A Prospective Longitudinal Study |
| title_full_unstemmed | Fertility Rate and Sperm DNA Fragmentation Index following Varicocelectomy in Primary Infertile Men with Clinical Varicocele: A Prospective Longitudinal Study |
| title_short | Fertility Rate and Sperm DNA Fragmentation Index following Varicocelectomy in Primary Infertile Men with Clinical Varicocele: A Prospective Longitudinal Study |
| title_sort | fertility rate and sperm dna fragmentation index following varicocelectomy in primary infertile men with clinical varicocele a prospective longitudinal study |
| topic | dna fragmentation infertility semen analysis varicocele varicocelecto |
| url | https://www.ijfs.ir/article_708784_567a818ec34b80c6b5cf14a8d3f4e056.pdf |
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