MicroRNA Nanotherapeutics for Lung Targeting. Insights into Pulmonary Hypertension
In this review, the potential future role of microRNA-based therapies and their specific application in lung diseases is reported with special attention to pulmonary hypertension. Current limitations of these therapies will be pointed out in order to address the challenges that they need to face to...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/9/3253 |
| _version_ | 1797568842495426560 |
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| author | Susana Carregal-Romero Lucía Fadón Edurne Berra Jesús Ruíz-Cabello |
| author_facet | Susana Carregal-Romero Lucía Fadón Edurne Berra Jesús Ruíz-Cabello |
| author_sort | Susana Carregal-Romero |
| collection | DOAJ |
| description | In this review, the potential future role of microRNA-based therapies and their specific application in lung diseases is reported with special attention to pulmonary hypertension. Current limitations of these therapies will be pointed out in order to address the challenges that they need to face to reach clinical applications. In this context, the encapsulation of microRNA-based therapies in nanovectors has shown improvements as compared to chemically modified microRNAs toward enhanced stability, efficacy, reduced side effects, and local administration. All these concepts will contextualize in this review the recent achievements and expectations reported for the treatment of pulmonary hypertension. |
| first_indexed | 2024-03-10T20:02:50Z |
| format | Article |
| id | doaj.art-da0c04dc5b4340f19a6c2d7fc2c8bfe0 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T20:02:50Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-da0c04dc5b4340f19a6c2d7fc2c8bfe02023-11-19T23:27:52ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-05-01219325310.3390/ijms21093253MicroRNA Nanotherapeutics for Lung Targeting. Insights into Pulmonary HypertensionSusana Carregal-Romero0Lucía Fadón1Edurne Berra2Jesús Ruíz-Cabello3Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo de Miramón 182, 20014 San Sebastián, SpainCenter for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo de Miramón 182, 20014 San Sebastián, SpainCenter for Cooperative Research in Bioscience (CIC bioGUNE), Buiding 800, Science and Technology Park of Bizkaia, 48160 Derio, SpainCenter for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo de Miramón 182, 20014 San Sebastián, SpainIn this review, the potential future role of microRNA-based therapies and their specific application in lung diseases is reported with special attention to pulmonary hypertension. Current limitations of these therapies will be pointed out in order to address the challenges that they need to face to reach clinical applications. In this context, the encapsulation of microRNA-based therapies in nanovectors has shown improvements as compared to chemically modified microRNAs toward enhanced stability, efficacy, reduced side effects, and local administration. All these concepts will contextualize in this review the recent achievements and expectations reported for the treatment of pulmonary hypertension.https://www.mdpi.com/1422-0067/21/9/3253non-coding RNAmicroRNAreplacement therapyantisense-mediated inhibitionmimicRNAlung targeting |
| spellingShingle | Susana Carregal-Romero Lucía Fadón Edurne Berra Jesús Ruíz-Cabello MicroRNA Nanotherapeutics for Lung Targeting. Insights into Pulmonary Hypertension International Journal of Molecular Sciences non-coding RNA microRNA replacement therapy antisense-mediated inhibition mimicRNA lung targeting |
| title | MicroRNA Nanotherapeutics for Lung Targeting. Insights into Pulmonary Hypertension |
| title_full | MicroRNA Nanotherapeutics for Lung Targeting. Insights into Pulmonary Hypertension |
| title_fullStr | MicroRNA Nanotherapeutics for Lung Targeting. Insights into Pulmonary Hypertension |
| title_full_unstemmed | MicroRNA Nanotherapeutics for Lung Targeting. Insights into Pulmonary Hypertension |
| title_short | MicroRNA Nanotherapeutics for Lung Targeting. Insights into Pulmonary Hypertension |
| title_sort | microrna nanotherapeutics for lung targeting insights into pulmonary hypertension |
| topic | non-coding RNA microRNA replacement therapy antisense-mediated inhibition mimicRNA lung targeting |
| url | https://www.mdpi.com/1422-0067/21/9/3253 |
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