The role of folic acid in carcinogenesis, diagnosis, and treatment of cancer
Introduction: Folic acid, also known as folate, is one of the water-soluble B vitamins which its derivatives are involved in many metabolic reactions as cofactor, that are mostly contributed in cell growth. Regarding the role of derived cofactors from this vitamin in reactions such as methylation, p...
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Negah Institute for Scientific Communication
2018-05-01
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| Series: | International Journal of Biomedicine and Public Health |
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| Online Access: | http://www.ijbmph.com/article_67209_3c948973ab8261ed51273ee9887a90b4.pdf |
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| author | Jalil Rashedi Maryam Akbarzadeh Hosein Ajami Khiyav Sanya Haiaty Vahid Vahedian Omid Hasanzadeh Nazila Fathi |
| author_facet | Jalil Rashedi Maryam Akbarzadeh Hosein Ajami Khiyav Sanya Haiaty Vahid Vahedian Omid Hasanzadeh Nazila Fathi |
| author_sort | Jalil Rashedi |
| collection | DOAJ |
| description | Introduction: Folic acid, also known as folate, is one of the water-soluble B vitamins which its derivatives are involved in many metabolic reactions as cofactor, that are mostly contributed in cell growth. Regarding the role of derived cofactors from this vitamin in reactions such as methylation, production of thymidine and purines; seems that there is a relationship between this vitamin and cancer. Methods: We searched Medline/Pubmed, Scopus, Embase and Web of Science (2000-2017) using term folic acid, carcinogenesis, diagnose and treatment. Our focused was on the articles published within the past 5 years and type of study in culture media, animal models and clinical trials were in our favor. Results: Candidate mechanisms in carcinogenesis for folic acid include 1: changes in DNA and RNA methylation 2: Damage to the integrity and stability of DNA 3: disruption in repair system of DNA. Conclusion: Folic acid in carcinogenesis acts as a double-edged sword. The activity type of folic acid depends on the physiological conditions, dosage of the vitamin, age, individual genotypes, target tissues and stage of the disease in patients. High growth rate of cancer cells leads to increase in cell requests of the vitamin, and on the other hand the cells enhance the number of receptors improving the vitamin absorption. Therefore, increasing number of cell surface receptors, it can be applied for non-invasive diagnosis and target therapy. |
| first_indexed | 2024-12-17T03:28:49Z |
| format | Article |
| id | doaj.art-da0e1cff7c5d422bb0c1bd7849e554a6 |
| institution | Directory Open Access Journal |
| issn | 2588-5375 2588-5375 |
| language | English |
| last_indexed | 2024-12-17T03:28:49Z |
| publishDate | 2018-05-01 |
| publisher | Negah Institute for Scientific Communication |
| record_format | Article |
| series | International Journal of Biomedicine and Public Health |
| spelling | doaj.art-da0e1cff7c5d422bb0c1bd7849e554a62022-12-21T22:05:19ZengNegah Institute for Scientific CommunicationInternational Journal of Biomedicine and Public Health2588-53752588-53752018-05-011211412110.22631/ijbmph.2018.117032.101767209The role of folic acid in carcinogenesis, diagnosis, and treatment of cancerJalil Rashedi0Maryam Akbarzadeh1Hosein Ajami Khiyav2Sanya Haiaty3Vahid Vahedian4Omid Hasanzadeh5Nazila FathiDepartment of laboratory sciences, Faculty of Para medicine, Tabriz University of medical sciences, Tabriz, IranStem Cell and Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, IranIslamic Azad University of Tabriz Faculty of Veterinary Medicine, Tabriz, IranDepartment of Clinical Biochemistry and Laboratory Medicine, Tabriz University of Medical Sciences, Tabriz, IranRofeydeh Rehabilitation Hospital, University of Social Welfare and Rehabilitation Science (USWR), Tehran, IranIslamic Azad University of Tabriz, Tabriz, IranIntroduction: Folic acid, also known as folate, is one of the water-soluble B vitamins which its derivatives are involved in many metabolic reactions as cofactor, that are mostly contributed in cell growth. Regarding the role of derived cofactors from this vitamin in reactions such as methylation, production of thymidine and purines; seems that there is a relationship between this vitamin and cancer. Methods: We searched Medline/Pubmed, Scopus, Embase and Web of Science (2000-2017) using term folic acid, carcinogenesis, diagnose and treatment. Our focused was on the articles published within the past 5 years and type of study in culture media, animal models and clinical trials were in our favor. Results: Candidate mechanisms in carcinogenesis for folic acid include 1: changes in DNA and RNA methylation 2: Damage to the integrity and stability of DNA 3: disruption in repair system of DNA. Conclusion: Folic acid in carcinogenesis acts as a double-edged sword. The activity type of folic acid depends on the physiological conditions, dosage of the vitamin, age, individual genotypes, target tissues and stage of the disease in patients. High growth rate of cancer cells leads to increase in cell requests of the vitamin, and on the other hand the cells enhance the number of receptors improving the vitamin absorption. Therefore, increasing number of cell surface receptors, it can be applied for non-invasive diagnosis and target therapy.http://www.ijbmph.com/article_67209_3c948973ab8261ed51273ee9887a90b4.pdffolic acidcarcinogenesistherapeuticsdiagnosis |
| spellingShingle | Jalil Rashedi Maryam Akbarzadeh Hosein Ajami Khiyav Sanya Haiaty Vahid Vahedian Omid Hasanzadeh Nazila Fathi The role of folic acid in carcinogenesis, diagnosis, and treatment of cancer International Journal of Biomedicine and Public Health folic acid carcinogenesis therapeutics diagnosis |
| title | The role of folic acid in carcinogenesis, diagnosis, and treatment of cancer |
| title_full | The role of folic acid in carcinogenesis, diagnosis, and treatment of cancer |
| title_fullStr | The role of folic acid in carcinogenesis, diagnosis, and treatment of cancer |
| title_full_unstemmed | The role of folic acid in carcinogenesis, diagnosis, and treatment of cancer |
| title_short | The role of folic acid in carcinogenesis, diagnosis, and treatment of cancer |
| title_sort | role of folic acid in carcinogenesis diagnosis and treatment of cancer |
| topic | folic acid carcinogenesis therapeutics diagnosis |
| url | http://www.ijbmph.com/article_67209_3c948973ab8261ed51273ee9887a90b4.pdf |
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